Terminal Illness Causes Family Secret to Surface in Heartfelt Story of Severed Trust and Forgiveness

Dallas, TX, March 11, 2021 — Natalia Foster is the family secret that her biological father, Joe Russo, was supposed to take to his grave. But when Natalia learns that Joe, an Italian man she’s never met, is dying of a terminal illness, she’s forced to confront the truth of her parentage and make a difficult decision: Should she remain in the shadows or make herself known to Joe and his family?

The Wool Over Their Eyes, from Dione Martin, is an authentic, heartfelt story about complex family dynamics and the emotions that must be unpacked when long-buried secrets push their way to the surface.

Joe’s immediate family, including his devoted wife, Rosa, know nothing of Natalia’s existence. Her gray eyes — exactly like Joe’s — and simple math prove that Natalia is a product of Joe’s infidelity, making a mockery of Rosa’s marriage. If his family discovers the whole truth — that Natalia is not only illegitimate but also Black — family bonds will be shattered. 

In the midst of Natalia’s family drama and pain, another life-changing decision emerges. Natalia must choose between two loves — a long-lost one and a new one. Her ex-boyfriend, Tyler Davis, who captured her heart and connected with her soul, resurfaces. But she meets a handsome doctor, David Duplessis, who’d cared for her father. Just as the relationship begins to blossom, David commits an act that severs her trust and sends her spiraling further into her dark abyss. 

The Wool Over Their Eyes is loosely based on Martin’s personal experiences. She drew upon her own memories and insights of growing up without her biological father and being betrayed in her own marriage to inform her narrative and give her characters depth and authenticity.

“I wrote The Wool Over Their Eyes for fatherless girls, for women who have been betrayed, for those who have been rejected because of their race (or otherness) and for families that have been torn apart by secrets, lies and deception,” Martin reflects. “Healing is possible – through change, through empathy, through faith and through forgiveness.” 

Author Dione Martin was born and raised in New Orleans, where she spent much of her childhood and teen years reading. She earned her Bachelor’s in English from the University of Minnesota-Morris and her Master’s in Journalism from the University of Texas at Austin. She is currently a senior communications director at Brinker International. She lives in Dallas with her two daughters and enjoys running, cooking, performing arts and attempting DIY projects. The Wool Over Their Eyes is her debut novel, and she is working on her next one.

​For more information about the author, please visit www.dione-martin.com or follow her on Twitter (@DioneMartin30) or on Facebook (www.facebook.com/dionehmartin).

The Wool Over Their Eyes

Publisher: Inspire on Purpose

Release Date: March 5, 2021

ISBN-13: 978-1948903530

Available from Amazon.com

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SLEEP AWARENESS WEEK AND WORLD SLEEP DAY ARE SIGNIFICANT FOR 

NAPLES RESIDENT WHOSE HUSBAND DIED FROM COMPLICATIONS OF SLEEP APNEA

Mary Schaff leads efforts for Sleep Apnea Awareness and Education, and may have saved a Naples Man’s life 

NAPLES, FLA.  – During Sleep Awareness Week (March 14-20) and World Sleep Day (March 19), you may expect to hear the question “How are you sleeping?” It’s a basic question with a seemingly simple answer, but the answer could help to reveal some very serious health concerns. Naples area resident Mary Schaff knows this firsthand. Following the untimely death of her husband John in 2015, for which sleep apnea was identified as a contributing cause, Schaff has made it her mission to shed light on this serious yet highly-treatable condition.

In her advocacy, Schaff has developed a relationship with sleep expert Dr. Nancy Foldvary-Schaefer, DO, MS, director of the Sleep Disorders Center at Cleveland Clinic, and was involved in the development of the mobile app “Sleep by Cleveland Clinic.”  She has created the website oursleepapneastoryand Facebook page Our Sleep Apnea Story to help educate those interested in learning more about the effects of obstructive sleep apnea. 

“My goal is to help generate conversations that bring awareness to this potentially life-threatening condition – conversations within families and with friends and physicians,” said Schaff. “It’s as simple as starting with ‘How are you sleeping?’ With early detection and proper treatment, people can go on to live full lives with sleep apnea.”

One in three American adults suffers from obstructive sleep apnea, however an estimated 90 percent of people with sleep apnea go undiagnosed. Obstructive sleep apnea is defined as the involuntary cessation of breathing during sleep when the soft tissue of the palate collapses and falls against the back of the throat, effectively blocking the airway.

Naples resident Jim Millett credits hearing Schaff’s story for saving his life.  During a reception at a private club in Naples, Millet over heard Mary talking about how she lost her husband and what the symptoms for sleep apnea include.

As Schaff was speaking, Millett quickly realized that he suffered from most of the symptoms that she had mentioned. 

“That evening I spoke to my wife about Mrs. Schaff’s conversation and her loss,” said Millett. “My wife was quick to remind me that she had mentioned many times my snoring and occasional gasping for breath. That following morning is when I called to schedule a doctor’s appointment and begin the process.”

Millett’s visit to the doctor resulted in a scheduled sleep test and the ultimate diagnosis of severe sleep apnea. He was prescribed a CPAP machine.

“The CPAP has changed my life, I sleep at least 6 hours straight whereas before I was awake every 15 minutes or so. I now feel energized and rested every morning,” said Millett. “I feel that hearing Mrs. Schaff’s conversation that day was no coincidence. I’m grateful that she’s able to speak of her loss and bring awareness to others. I too often hear friends and fellow co-workers complain of the same symptoms that I suffered from and now encourage them to make an appointment ASAP.  

For more information on sleep apnea and Mary’s mission, visit:  www.oursleepapneastory.com or https://www.facebook.com/Our-Sleep-Apnea-Story

The Ontario Pharmacists Association Partners with MedEssist Ltd. to Offer Pharmacies Tools for Managing COVID-19 Vaccinations

TORONTO, March 11, 2021 /CNW/ - The Ontario Pharmacists Association (OPA) is pleased to announce a partnership agreement with MedEssist Ltd. to offer a digital health solution that will enable community pharmacies across Ontario to meet the immediate demand for COVID-19 vaccinations. The collaboration is part of a broader plan to enable the future of Pharmacy Health Hubs.

Together, OPA and MedEssist will endorse and market the effective patient-first, digital health solution which will be available for purchase by pharmacies. The solution is a web-based tool that can also be accessed on mobile. As Canada's first and only inventory-based, patient-triaging platform for pharmacies, MedEssist's system is designed to enable pharmacies to operate more efficiently and provide exceptional patient care while minimizing vaccine wastage. MedEssist's innovative system has helped pharmacies across Canada to successfully manage a record-breaking flu vaccination campaign in 2020.

"The COVID-19 pandemic continues to present opportunities to enhance how pharmacy professionals provide care to patients," says Lilliette Davidson, Vice President, Business Management & Development with the Ontario Pharmacists Association. Empowering pharmacies to operate more efficiently while minimizing wastage is the focus of this tool. "It is important for OPA to align with a technology partner who supports the immediate needs of pharmacies when managing patients especially for administering the COVID-19 vaccine."

MedEssist's unique workflow designs prevent overbookings and vaccine wastage. An inventory-based model enables pharmacies to seamlessly triage and schedule patients for COVID-19 vaccines (including second-dose appointments). The comprehensive solution accounts for every step of this vaccine rollout, pre-registration, scheduling, documentation, automated appointment reminders, and COVID-19 screening. Diversity and inclusion are important values of OPA. MedEssist's multilingual platform enables pharmacists to manage a variety of patients, including senior patients with limited access to technology.

"I've been an OPA member for over 10 years and I am so excited to work side-by-side with OPA to push the boundaries for what community pharmacies are able to accomplish together." Michael Do, Co-Founder of MedEssist and a Registered Pharmacist in Ontario.

Over the next few months and into 2022, OPA will announce new clinical services and expand upon providing pharmacies with a reliable digital infrastructure to help provide a bigger role in daily patient care.

About OPA

The Ontario Pharmacists Association is committed to evolving the pharmacy profession and advocating for excellence in practice and patient care. With more than 10,000 members, OPA is Canada's largest advocacy organization, professional development and drug information provider for pharmacy professionals across Ontario. By leveraging the unique expertise of pharmacy professionals, enabling them to practise to their fullest potential, and making them more accessible to patients, OPA is working to improve the efficiency and effectiveness of the healthcare system. The pharmacy sector plays a strong role in Ontario with an economic impact of more than $6.3 billion across 4,600 pharmacies, employing 60,000 Ontarians. Visit: https://www.opatoday.com.

About MedEssist

MedEssist is a Toronto-based healthcare company that helps community pharmacies manage and coordinate medication refills, vaccinations, COVID-19 testing, and other healthcare services. MedEssist turns pharmacies into proactive healthcare hubs for their communities. By modernizing these pharmacies, MedEssist is changing how large-scale health initiatives such as COVID-19 vaccinations can be adapted to meet the requirements of local communities.

MedEssist's core mission is to improve the everyday health of patients by empowering them to access, understand, and manage their health through technology. MedEssist has been relied on since 2018 across Ontario for patient-centric services through supporting community pharmacies.

Please visit the website at www.medessist.ca and use the chat feature to get in touch with the team.

SOURCE Ontario Pharmacists Association

Powerful True Story Inspires Others to Seek Adventure, Turn Each Day into a Gift

Fort Wayne, IN, March 12, 2021 — Brittany Moser’s short life was not defined by how she died, but rather, by how she lived each day to the fullest and the profound impact she had on those around her. Brittany died from a rare condition, Addison’s disease, in 2017 at the age of 32. She had been a happy-go-lucky flight attendant, soaring high above reality, when her diagnosis suddenly brought her down to earth.

Rather than buckle under the weight of fear, she chose to be fearless and embarked upon the adventure of a lifetime with her best friend — her father. Free and Fearless: The Amazing Impact of One Precious Life is Brittany’s unforgettable story as told by her father, Philip Moser.

“This book is not about the grief of losing a child, but about making the most out of what we are given and living our lives positively and not out of fear,” Moser writes. “Brittany inspired me, an ordinary farm boy, to explore life, to climb mountains and to write a book.”

Free and Fearless is an honest, poignant account of Brittany’s legacy and the ripple effect that her outlook on life had on everyone who knew her. Philip hopes that by hearing her story, readers will be inspired by Brittany’s contagious spirit and unwavering desire for new adventures and experiences — even in the shadow of an incurable illness.

Among Brittany’s valuable life lessons that Philip shares with readers are:

1. How precious life is and how we can affect the people around us;
2. How an open mind and a positive attitude can inspire us to do things we never thought possible;
3. How to move out of our comfort zones and into a challenging existence that can turn each day into an exciting gift to be explored;
4. How to not let fear control us, and to use our abilities to seek unique, positive and inspiring adventures;
5. To embrace change as a natural part of life;
6. And finally, that we won’t be remembered by our things or our savings accounts, but by how we made other people feel.

“I want to share the same inspiration that I received for 32 years,” Philip added. “In the end, love truly does conquer all, and Brittany wanted us to know that.”

Author Philip Moser grew up on a farm in Angola, Indiana. After high school, he began working in different aspects of the grocery business, a career that continues to this day. He and his wife, Marilyn Wells, raised two incredible daughters, Camille and Brittany.  

For more information, please visit www.freeandfearlessbook.com or connect with the author on social media at https://www.facebook.com/philip.moser.73?ref=bookmarks.  A portion from the sale of each book will be donated to the National Adrenal Disease Foundation. 

Free and Fearless: The Amazing Impact of One Precious Life

ISBN-10: 1733086404                                                                                      

ISBN-13: 978-1733086400

Available from Amazon.comBarnesandNoble.comBooksaMillion.com and other online retailers

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4 Types of Fitness Classes That Can Motivate You to Get Active

If you’re keen on working out but having a hard time staying motivated, then exercise classes might give you the boost you’ve been looking for. While getting yourself to the gym for a solo workout is often impossible, heading off for a group class is usually easy to pull off. That’s because exercise classes are more fun than working out alone, and they successfully hold us accountable. There are lots of fitness classes out there, but here are four popular options to consider.

Dance Class

Humans have been dancing for as long as civilizations have existed, and probably a lot longer. It’s no surprise that even our ancestors appreciate an activity that’s as good for the body as it is for the soul. Not only is dancing a lot of fun, but it provides an excellent cardiovascular workout. There are all sorts of dance classes available, but the Latin-based Zumba has become especially popular in recent years.

Kickboxing Class

For an intense workout that doubles as a lesson in self-defense, consider registering for a kickboxing class. A rigorous group training program will get you in better shape and make you feel cool doing it. You don’t have to be a violent or aggressive person to enjoy these types of classes. Surrounded by friends and laughing all the way, kickboxing sessions will be truly joyous occasions.

Cycling Class

If cardio is your thing, then a cycling class with stationary bikes might be the perfect option for you. While riding a bike seems like an individual activity, you’ll find it’s much easier to stay motivated when you’re part of a class. The teacher and your classmates will inspire you to keep those wheels spinning, even after an hour of grueling exercise.

Yoga Class

For a fitness class that doubles as a mindfulness program, consider signing up for yoga. There’s a reason this eastern tradition has swept through the western world. Practitioners swear by yoga’s calming influence and corporal benefits. After just a few sessions, you should find your body is more limber and your mind more at ease. Once you become accustomed to the practice, you’ll have forged yourself a positive habit you can maintain for the rest of your life.

Staying motivated and maintaining a fitness program is much easier when you’re part of a class. That’s why any of these programs are sure to help you reach your fitness goals.

Training Center for At-Risk Women Offers Hope for Independence

Seattle, WA, March 12, 2021 — Women and children are particularly vulnerable to the dangers of living on the streets or in unsafe environments. Drug dealers, pimps and human traffickers lie in wait for new victims. Seattle spends a staggering $1 billion per year on fragmented programs to support its homeless, according to Puget Sound Business Journal, yet the challenges continue to grow. It’s time for a new approach.

Providence Heights is a forward-thinking, Christian-based nonprofit designed to empower Seattle’s women in need through housing, employment opportunities and personal development programs. The organization’s business model is revolutionary: Providence Heights plans to reinvest revenues generated through real-estate, commercial and entrepreneurial enterprises to create a sustainable source of income, something founder Christine Soule calls Capitalism for the Poor. Additionally, “Our unique retail space integration will secure revenue as well as provide apprenticeship, jobs and entrepreneurial skills,” Soule explains.

Phase I will provide housing and resilient growth programs for over 88 women (and children) at risk of losing their homes, or who simply need opportunities to regroup and equip themselves to not just survive but to thrive. Also for those who have come out of a program such as the Union Gospel Mission and are fully prepared to commit to changing the trajectory of their lives.

Phase II aims to provide housing for more than 200 women, including those with children. Once the revenue stream is firmly established in this phase, Providence Heights will enter Phase III — the final phase — when the organization will replicate this model from city to city. They hope to also empower similar organizations to use its successful blueprint to help those they serve. 

Providence Heights Founder and Chief Executive Officer Christine Soule is a lover of people and passionate about leading them toward a restored and dignified life. From her personal experience, she has great compassion for at-risk and abused women. She co-founded The Purpose and is a philanthropist, author and inventor. Her recently released book, Broken and Beautiful, chronicles her remarkable journey from trauma to triumph. Christine is also a mother of five and married to Mitch, the love of her life.

To get involved or for more information, please visit www.providenceheights.org, or watch https://youtu.be/8wDtsGBoc0Y

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Feeling Forwards: Learn How to Harness the Infinite Energy of Your Emotions

"Feeling Forwards helps you find the power within to overcome unbelievable challenges and take a quantum leap forwards." — TONY ROBBINS

New York, NY, March 12, 2021 — Everything you need to transform your life is already within you, asserts bestselling author and personal reinvention coach Elizabeth Gould. Her empowering new book, Feeling ForwardsHow to Become the Person Who Has the Life You Want, can help you say farewell to negative habits, release painful beliefs and tap into your full potential by harnessing the infinite energy generated by your emotions. 

Feeling Forwards is a thinking and feeling revolution. It’s not about writing to-do lists or visualizing every step toward a goal,” Elizabeth says. “Feeling Forwards is about living life as the complete person you’ve forgotten you already are and not as the person who’s just waiting to shine.”

The first half of Feeling Forwards is a fascinating deep-dive into the science proving the true power of our emotions, enabling them to travel forward and backward in time, influence pre-programmed computer outcomes, reverse aging, impact crime rates, fast-track personal reinvention and much more. After understanding the effects that our emotions can truly have on our lives, Elizabeth offers practical applications of the strategies in Feeling Forwardsusing real-life examples of those who’ve successfully integrated the principles into their lives.

Woven throughout are Elizabeth’s candid, personal stories of embracing these principles to thrive through several life-threatening events and dramatic personal upheavals.

The result is a refreshingly relatable, actionable guide to help you create the life you genuinely want to live. Feeling Forwards teaches you how to become the person who has the life you want … today. As Elizabeth reveals, “Today is the past of your future.”

About the Author

A bestselling author and founding member of Randi Zuckerberg’s global leadership school at the Zuckerberg Institute, Elizabeth Gould experiences the joy of working with people around the world to unlock their potential. She has spent decades interviewing thousands of successful professionals to understand how they behave to achieve what they want. Her work is endorsed by world-renowned life and business strategist, Tony Robbins. Feeling Forwards is her third book.

For more information, visit https://elizabethgould.com/ or connect with the author on social media at https://www.facebook.com/ElizabethGouldOfficial or https://www.instagram.com/elizabethgould_/

Feeling Forwards

ISBN-13: 979-8553733766

Available from Amazon.com

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Spring Agronomy Outlook: A Time to Plant, a Time to Prosper

Higher grain prices, more planted acres and strong demand for inputs make fertile ground for ag retailers 

DENVER (March 11, 2021)—Farm supply cooperatives and distributors are positioned to benefit from an active and profitable spring agronomy season driven by high commodity prices, strong input demand and an expected increase in planted acres of soybean, corn and wheat. 

After two strong agronomy seasons in 2020, ag retailers and wholesalers begin the 2021 planting season with favorable industry fundamentals and an opportunity to expand profit margins, according to a new report from CoBank’s Knowledge Exchange

“Barring additional weather shocks, spring 2021 is setting up to be a very strong agronomy season for crop input distributors,” said Kenneth Scott Zuckerberg, lead grain and farm supply economist with CoBank. “Improving profits for cooperative agronomy departments should help cushion the negative carry caused by an inversion in futures prices.”

Since last August, prices have increased more than 60% for corn and soybeans and nearly 20% for wheat, in response to tight ending stocks and continued strong demand from both export markets and domestic processors. The cyclical turn in grain prices, combined with robust government support payments, drove a surprise recovery in farmer income, leaving growers in a sound financial position heading into spring. 

While some producers may have missed out on the early gains in pricing by selling their corn and soybean crops in late September, U.S. net farm income aggregated for crop, dairy and livestock production grew by $38 billion in 2020. Those gains were driven in large part by historic government farm program payments of $46 billion. 

Farm debt and financial leverage ratios continue to increase, however, partly offsetting the positive financial picture for growers. Farmer debt-to-equity is projected to reach 16.1% in 2021 compared to 15.8% in 2020 and 12.7% in 2012, a situation that could become problematic should floating rate interest debt begin rising in anticipation of future inflation.

High grain prices, coupled with favorable supply-demand dynamics, will drive higher planted acreage, resulting in more crop input usage during the spring 2021 planting season. In aggregate, USDA expects slightly more than 10 million additional planted acres this year due primarily to prevent plant acres coming back into circulation.

Given the higher acreage forecasts, farmers are expected to purchase more fertilization products, specifically the principal macronutrients (nitrogen, potassium and phosphorous) during the spring planting season. Rising fertilizer prices are also a positive indicator for new sales and retailer margins.

Inventory levels of seed, fertilizer and crop protection products are largely expected to be sufficient for the projected increase in spring planted acres. However, logistical bottlenecks (mainly trucking and rail) remain as risk factors that could potentially create input shortages or delays in certain parts of the country.

Farmer prepayments to farm supply cooperatives increased during the final months of 2020, as growers bought crop inputs in advance to minimize tax liabilities.

Watch a video synopsis and read the report, Agronomy Outlook: A Time to Plant, a Time to Prosper.

About CoBank

CoBank is a $159 billion cooperative bank serving vital industries across rural America. The bank provides loans, leases, export financing and other financial services to agribusinesses and rural power, water and communications providers in all 50 states. The bank also provides wholesale loans and other financial services to affiliated Farm Credit associations serving more than 75,000 farmers, ranchers and other rural borrowers in 23 states around the country.

CoBank is a member of the Farm Credit System, a nationwide network of banks and retail lending associations chartered to support the borrowing needs of U.S. agriculture, rural infrastructure and rural communities. Headquartered outside Denver, Colorado, CoBank serves customers from regional banking centers across the U.S. and also maintains an international representative office in Singapore.

Delicious Ways to Incorporate Raw Honey into Your Daily Diet
Enjoy Endless Health Benefits from Nature’s Tastiest Golden Treasure 

Oley, PA. (March 10, 2021): If incorporated properly into daily diets, consuming natural, raw honey has shown to offer numerous health benefits in addition to great enhancing flavor and texture of a wide variety of dishes. By sticking to non-GMO, unfiltered organic honey as nature intended, we are opening ourselves up to a whole world of health benefits that require little to no effort to attain. By using enhanced products such as Oley Hemp’s OH! Raw Honey with CBD, consumers enjoy even greater benefits and flavor. Below are just a few simple ways to easily incorporate raw cbd honey into your daily diet. 

Raw honey by the spoonful 

There is absolutely nothing wrong with eating a spoonful of honey. As you have probably already observed, honey is loaded with antioxidants, helps with inflammation, improves gut health and provides a boost of energy. A tablespoon of honey contains about 64 calories, so when enjoyed in moderation, half a spoon to be exact, there is nothing wrong with adding this delightful treat to your daily diet, so long as you stick with organic products made from responsible brands that care about your health as much as you do. 

Honey lemonade 

A glass of warm water, juice of half a lemon, and a teaspoon of honey is a fantastic way to cleanse the stomach, fight sickness, improve gut health, and help lose weight by controlling cravings. Easily enjoyed at any time of day, warm honey lemonade is an easy beverage to make and introduces a rich mixture of fiber and pectin into your system that your body will most certainly thank you for. 

Breakfast time 

Raw honey goes with almost every breakfast food you can think of: Toast, oatmeal, pancakes, waffles, yogurt, a bowl of fruit, and the list goes on and on. The energy boosting properties of honey (through its heavy amount of glucose and fructose) are a fantastic way to start the day, and will help set and stabilize your blood sugar levels. 

Ranch dressing? Nope. Honey dressing. 

This one is a little less common, but raw honey actually works very well as a healthy alternative to traditional salad dressings. For salads with avocado, cucumbers, spinach, or tomatoes, it also works well specifically when mixed with a bit of salt and pepper, vinegar, or mustard. Wow your dinner guests with a unique dressing they will absolutely not forget. 

The perfect marinade 

If you have never thought of using honey to marinade fish or other meats, think again! When combined with other traditional marinade ingredients such as vinegar, lime or lemon juice, or citrus fruits, raw honey adds a special texturing effect to the tenderizing process. It also helps lock in the zesty moisture that makes meat-based dishes so wonderful to experience. 

# # # 

About OleyHemp 

OleyHemp is a family-run company on a mission to grow the best hemp to use in products that improve the lives of our family, friends, customers, and pets. Located in Oley, PA., OleyHemp is considered one of the leading producers of hemp and hemp-derived products that deliver a pure and natural wellness experience from high quality, organically grown hemp in farms across the US. Founded in 2019, OleyHemp takes great pride in preserving the quality and transparency of their products.   


For more information on OleyHemp, visit them online at www.oleyhemp.com or on Facebook or Instagram.    

A cocktail of monoclonal antibodies produced in plants demonstrates high neutralizing potency to fight COVID-19 and variants

QUEBEC CITY and VAL-DE-REUIL, France, March 10, 2021 /CNW Telbec/ - Dr Louis-Philippe Vézina Dr Véronique Gomord (respectively CEO and CSO of Angany), and Pr. Rogier W. Sanders and Dr Marit van Gils of University Medical Centers in Amsterdam (Amsterdam UMC) announce today significant advances made in the accelerated development of a preventive and curative product based on highly potent neutralizing monoclonal antibodies (NAbs) against the SARS-CoV-02 virus and its variants. 

The new variants are a growing threat. NAbs-based products can be quickly adapted to the evolution of the pandemic. They represent a necessary complement to vaccines, especially in the context of multiplying variants. They can help in 2 ways:

  1. Curative: to treat patients who are sick or at risk, especially with the emergence of variants; 
  2. Preventive: to protect healthcare workers and first responders against emerging variants or when vaccination coverage has not been established.

"In early spring 2020, we had isolated several monoclonal antibodies from infected patients and had identified two as some of the most potent NAbs in vivo," says Prof Sanders of Amsterdam UMC. (https://science.sciencemag.org/content/369/6504/643). "They have since been fully characterized and studies in animal models, including non-human primates, suggest that protection could be achieved with doses lower than 5 mg per kg of body weight and as low as 1mg per kg of body weight in therapeutic and prophylactic settings, respectively" (https://www.researchsquare.com/article/rs-235272/v1). 

In France, Angany's R&D laboratory has managed to produce these monoclonal antibodies with a plant-based platform initially designed for the manufacturing of a new generation of vaccines against allergies.  "The relevance of NAbs as preventive or therapeutic treatments is all about metrics: higher neutralization potency means lower effective doses needed, and directly translates into the capacity to treat a higher number of patients (availability), at a lower cost (affordability), states Dr Gomord. "Angany's new generation plant-based antibody manufacturing technology is one of the few that can provide the scalability and volume capacity required in the current context, and it is one of the rare options available, if the global community wants to take full advantage of the pivotal impact such NAbs can have on the pandemic crisis". 

Scientists at Amsterdam UMC are on close watch of the evolution of variants. This unique collaboration between Angany and Amsterdam UMC is of strategic importance for the development of Nab-based therapeutics.

"Monoclonal antibody therapeutics are often prepared as a mix (cocktail) of NAbs that can extend their neutralizing capacity to new variants. Lately, at least one new monoclonal with high potency against the South African variant has been identified and others will be," states Dr Vézina. "With our new generation technology, the turnover time is a matter of weeks. We should be able to include this new NAb in time for the initiation of clinical trials in the next few weeks. We cannot ignore the possibility that new variants will emerge. If we want to prevail over this pending threat, it is essential that the technology we rely upon for the manufacturing of NAbs be able to respond rapidly and with surge capacity. The matter of national autonomy of the production is as important for NAbs as it is for vaccines." 

About ANGANY
ANGANY is an emerging, private Franco-Canadian pharmaceutical company dedicated to fighting allergy with a novel approach to immunotherapy. The company is pursuing a mission initiated in France in 2010. Angany's CEO is Dr Louis-Philippe Vézina, a successful pharma entrepreneur (co-founder and former CSO of one of the largest Canadian biotech companies), world renowned for his expertise in the design and production of new generations of vaccines.

Angany's goal: help people with allergies get their life back. Leveraging over 30 years of research in biotechnology, immunology and vaccinology, and after more than $ 15M of R&D investments, ANGANY has tackled the specific challenges of allergy to invent a new generation of pharmaceutical products. In a world first, ANGANY has developed a first-in-class proprietary vaccine platform based on synthetic biology. With this proprietary self-adjuvanted vector, ANGANY has demonstrated at the preclinical level the possibility of reversing a specific allergy dynamic. Angany is currently preparing a treatment for peanut allergy and products for human allergy to cats.

ANGANY has also developed a flexible, fast and easily scalable 3rd generation plant-based production platform. 

ANGANY anticipates that its vaccine platform will eventually find direct applications in domains other than allergy, namely in cancer immunotherapy and in the treatment of autoimmune diseases.

Angany's involvement in the fight against COVID-19
The COVID-19 pandemic constituted a call-to-arms for Angany. The company chose to assist by leveraging one specific aspect of its technology: the ability to quickly develop and scale-up the production of monoclonal antibodies. Backed by a prestigious team of researchers, COVID-Nabs can play a pivotal role in resolving the current socio-economic crisis.

For more information, visit angany.com.

SOURCE Angany inc.