Research in sheep suggests possible early test for fetal heart health
UNDER STRICT EMBARGO UNTIL 01.00 GMT THURS 5 DECEMBER 2019
Not for publication or broadcast before this time
Changes in heart rate, due to low oxygen conditions, experienced by the fetus during pregnancy, could be used to predict the future heart health of babies, shows research published in The Journal of Physiology today.
Previous research has shown that sustained low levels of oxygen (called chronic hypoxia) during pregnancy significantly impair the growth of the fetus, leading to a condition known as intrauterine growth restriction (IUGR). Chronic hypoxia during pregnancy can also impair the development of key organs, imposing consequences for life-time health risks, such as an increased heart disease risk.
The main causes of low oxygen during fetal development are complications with the placenta. Researchers at the University of Cambridge and the University of Washington led by Dino Giussani and Martin Frasch modelled such conditions during pregnancy by placing pregnant sheep in an environment with lower than normal oxygenation, similar to experiencing high altitude. They then looked at the fetal heart separated from any influences of the rest of the body, as a way to see if the heart shows any sign of “remembering” the effects of lower than normal oxygen that was experienced in the womb.
The way that they determined this was by looking at something called heart rate variability, which refers to changes in heart rate that normally occur in our hearts. Analysis of the patterns of these changes in heart rate were able to tell them if the hearts of the fetuses were impacted in the long term.
This research may have important clinical implications. If babies from complicated pregnancies are identified to have abnormal fetal heart rate patterns, then doctors could follow the development of these children more closely to better protect against any future risk of heart disease.
Martin Frasch, first author on the study said:
“We are excited about these results and the ability it may give clinicians to assess in a new way the hearts of kids who don’t show symptoms, who may have underlying heart problems. A good example of this would be kids in Brazil whose mothers were infected with the Zika virus. While they may not have symptoms, they may still actually have important problems with their hearts that we should be addressing.”
Notes for Editors
Full paper title: First evidence that intrinsic fetal heart rate variability exists and is affected by hypoxic pregnancy https://physoc.onlinelibrary.wiley.com/doi/10.1113/JP278773 (link will only work after the embargo date. Before then, please email the press office for a copy of the paper)
The Journal of Physiology publishes advances in physiology which increase our understanding of how our bodies function in health and disease. http://jp.physoc.org
The Physiological Society brings together over 4,000 scientists from over 60 countries. The Society promotes physiology with the public and parliament alike. It supports physiologists by organising world-class conferences and offering grants for research and also publishes the latest developments in the field in its three leading scientific journals, The Journal of Physiology, Experimental Physiology and Physiological Reports. www.physoc.org
Tis' the season to be jolly. You partied and drank too much the night before and perhaps the one before that. Today, you have a business meeting or brunch with the inlaws. Although you might feel like you want to crawl into a hole from your hangover, you can’t afford to look like you have one. What is your skincare SOS game plane? We turned to Dr. Manish Shah, a Board-Certified Denver, Colorado Plastic Surgeon for some tricks that will have you looking fresh as a daisy even if they don’t cure that queasy feeling and headache.
Remove your makeup the night before
This is a tough one. If you come home stumbling at 3am, this is probably the last thing on your mind. If you can manage to do it, you’re one step ahead of the game. If going to the sink is too much effort, use cleansing cloths such as e.l.f. Cosmetics Hydrating Water Cleansing Cloths. They easily remove makeup and help nourish the skin with purified water. Infused with aloe and Vitamins B & E, the materials cool on contact and soothe and moisturize skin.
Hydrate
The number one thing alcohol does is dehydrate your entire body, including your skin," says Dr. Shah. "When skin is dehydrated it looks sallow, fine lines are more noticeable, and pores become obvious."
Dehydration is the main reason your skin looks terrible when you wake up. While drinking water is wise, the effects of that internal hydration won't immediately show up externally, says Dr. Shah. For a quick fix, he suggests a sheet mask that contains hyaluronic acid, a molecule that draws moisture to the skin. Try: Estee Lauder Advanced Night Repair Concentrated Recovery PowerFoil Mask
Put your face on ice
Skin redness can be caused by alcohol dilating your blood vessels. One way to reduce this is to put a cold compress on the affected area for a few minutes. But be warned, extended periods of drinking can cause permanent redness and skin damage.
Jade Rollers or Massage
You can use any jade roller (put it in the freezer for a few minutes for a cooling effect) or even just your fingers. Dr. Shah says that the goal is to energize and lift the skin by promoting lymphatic drainage (aka de-puffing).
De-Puff Your Eyes
After a night or two of drinking, the eyes become bloodshot because tiny blood vessels on the eye surface become red and inflamed.” Also, the diuretic effects of alcohol can lead to dehydration, which tells your body to hold onto more water weight. That fluid retention also prompts next-day puffiness.
You can purchase a product such as Skyn Iceland hydro cool firming eye gels. If you don’t have something like this in the house, you can substitute chamomile tea. Steep the tea bags in hot water, take them out until they cool, and put one on each eye for 10 minutes.
Exfoliate
Dr. Shah recommends giving your skin a good but gentle scrub. "Exfoliate off sallow, alcohol-damaged skin cells. You do not need to break the bank to do this. Dr. Shah suggests: St. Ives Invigorating Face Scrub – Apricot. This product can be found online and at most drug stores.
Seal Your Skin With A Spritz- And Not Champagne
After you have done all of the “damage control” you can give you face a final spritz of moisture with a product like Fresh Vitamin Nectar Antioxidant Glow Water. This energizing spray is packed with skin-brightening nutrients derived from citrus fruit, plus a blend of magnesium and zinc, to help snap sleep-deprived and hungover skin into shape.
Dr. Shah cautions that he does not endorse habitual binge drinking or alcohol abuse. These tips are for those who have overindulged on occasion. Aside from the obvious mental and physical effects of alcohol abuse, it can also cause harmful long term consequences to the skin which cannot be “fixed” by the tips given above.
Dr. Shah is not paid or in any manner affiliated with the products he mentions.
Manish Shah, M.D., F.A.C.S. was born in Canada and raised in the Washington, D.C. area. He graduated with honors from the University of Pennsylvania, receiving a degree in biomedical engineering. He then completed his medical training at the University of Virginia, earning his Medical Doctorate. During this time, he also completed a one-year fellowship in microsurgery research at the New York University School of Medicine / Institute of Reconstructive Plastic Surgery. As a prelude to his plastic surgery training, Dr. Shah completed a rigorous five-year training program in General and Trauma Surgery at Emory University and the Medical College of Georgia. His formal training in Plastic and Reconstructive Surgery was completed at the Univ. of Tennessee College of Medicine – Chattanooga Unit. After completing his plastic surgery training, he moved to New York City when he was selected for the prestigious Aesthetic Surgery Fellowship at Manhattan Eye, Ear, and Throat Hospital. He underwent extensive, advanced training in aesthetic surgery of the face, breasts, and body at the hands of some of the most renowned cosmetic surgeons in the world. This fellowship is widely considered to be the best of its kind in the world. Dr. Shah is one of only a select few plastic surgeons in the country who have undergone formal post-graduate training in aesthetic surgery.
Dr. Shah’s specialties include revision facial aesthetic surgery, rhinoplasty (“nose reshaping”), and aesthetic surgery of the breast (breast augmentation, breast lift, breast reduction). He is, however, well-trained in all areas of aesthetic surgery.
Dr. Shah’s aim is to obtain a natural appearing transformation that complements the real you!
Dr. Shah is a Clinical Assistant Professor of Surgery at the University of Colorado Health Sciences Center. He maintains a private practice in Aesthetic Plastic Surgery in the Cherry Creek neighborhood of Denver.
Dr. Shah is a member of the American Society of Plastic Surgeons, the American Society of Aesthetic Plastic Surgery, the International Society of Aesthetic Plastic Surgery, the Rhinoplasty Society, and the European Academy of Facial Plastic Surgery.
Dr. Shah is board-certified by the American Board of Plastic Surgery.
New approach to treating cystic fibrosis could lower risk of lung transplants and death, RCSI study
DUBLIN, Dec. 3, 2019 -- A new approach to treating people with cystic fibrosis (CF) has been shown to reduce inflammation, which has the potential to reduce the need for lung transplants and lower the risk of death.
CF is a genetic disease that affects about 1,300 children and adults in Ireland and 70,000 worldwide. The main cause of death in people with CF is lung disease, which is driven by severe inflammation and chronic infection in the airways.
While recent years have seen the emergence of several new therapies aimed at improving lung function and survival, the lack of effective anti-inflammatory and anti-infective treatments for these individuals continues to represent a significant challenge.
The researchers found that one of the most aggressive bacteria found in the lungs of those with CF caused certain immune cells to change their metabolism. This change caused the immune cells to produce a protein that causes more inflammation. They identified that high levels of the protein were associated with worse lung function and a higher risk of death or need for a lung transplant.
The team then used a small molecule called MCC950 to reduce levels of the protein in a laboratory model of CF. In addition to reducing inflammation, this also helped clear the lungs of bacteria. This marks the first time that researchers were able to stop this protein in CF in vivo by targeting cell metabolism, which could potentially lead to a new approach to treating inflammatory diseases like CF.
“This is an important first step to significantly improving patient outcomes for people with cystic fibrosis. While more testing is required before delivering this to patients, we believe these results are very promising and could make this molecule a candidate for clinical trials,” said Professor Gerry McElvaney, the study’s joint senior author and Professor of Medicine at RCSI.
RCSI researchers, including joint senior and corresponding author Dr Emer Reeves, carried out the study in collaboration with the University of Duisberg-Essen and the Trinity Biomedical Sciences Institute. The research was funded by the StAR (Strategic Academic Recruitment) MD Programme, which aims to transfer impactful research discoveries to clinical practice more quickly for the benefit of patients.
"Previously, people with CF had a very low life expectancy. Due to improvements in medical treatment, these individuals are now living longer. However, they still suffer from a very severe disease. We hope that this advancement can lead to further improvements in outcome, better quality of life and eventually a normal life expectancy for our patients,” said Dr Oliver McElvaney, the study’s lead author.
RCSI is ranked among the top 250 (top 2%) of universities worldwide in the Times Higher Education World University Rankings (2020) and its research is ranked first in Ireland for citations. It is an international not-for-profit health sciences institution, with its headquarters in Dublin, focused on education and research to drive improvements in human health worldwide. RCSI has been awarded Athena Swan Bronze accreditation for positive gender practice in higher education.
Avicanna to Supply UK Market with Cannabis-Based Medicinal Products Through Distribution Agreement with the LYPHE Group
/NOT FOR DISTRIBUTION TO UNITED STATES NEWSWIRE SERVICES OR FOR DISSEMINATION IN THE UNITED STATES. ANY FAILURE TO COMPLY WITH THIS RESTRICTION MAY CONSTITUTE A VIOLATION OF UNITED STATES SECURITIES LAWS./
TORONTO, Dec. 3, 2019 /CNW/ - Avicanna Inc. ("Avicanna" or the "Company") (TSX: AVCN) (OTCQX: AVCNF) (FSE: 0NN), a biopharmaceutical company focused on the development, manufacturing and commercialization of organic and sustainable plant-derived cannabinoid-based products, is pleased to announce that the Company has entered into an importation and distribution agreement (the "Agreement") with Astral Health Ltd. ("Astral"), the operating subsidiary of the LYPHE Group Ltd ("LYPHE Group" or "LYPHE") to supply its cannabis-based medicinal products ("CBMPs") to patients in the United Kingdom under the MHRA 'specials' programme.
"We look forward to the opportunity to provide access to our cannabis-based medicinal formulations to a population and medical community that is seeing increased demand for quality evidence-based products, such as our proprietary research-backed formulations. Both the Astral and Avicanna teams are aligned on the long-term vision and more importantly are qualified to provide the medical community in the United Kingdom with safe, effective and superior cannabinoid-based solutions, education and training," stated Aras Azadian, Chief Executive Officer.
Dean Friday, Chief Executive Officer of LYPHE, commented "We are very proud to be partnering with Avicanna in bringing their products to the UK market. Avicanna are market-leaders in terms of product quality, and their research-backed formulations give the company a distinct advantage in the UK market".
Under the Agreement, Avicanna will supply Astral with CBMPs, and both Avicanna and Astral will work together to achieve key strategic milestones in the United Kingdom related to market activation, market access and safety. The parties will also work together to collaborate on medical education programs with a focus on safety, dose guidance and efficacy. The Agreement will allow Avicanna to begin generating revenue from a growing UK market, while providing patients with increased access to the life-changing medicines they require.
It is expected that the CBMPs will be prepared in Colombia using Avicanna's proprietary research-backed formulations, using cannabis extracts from Santa Marta Golden Hemp S.A.S., a subsidiary of Avicanna, and manufactured at the facilities of Avicanna's exclusive Colombian manufacturer, Altea Farmaceutica S.A. using Good Manufacturing Practices (GMP).
To the knowledge of the Company, it carries out its operations in compliance with all applicable laws in the jurisdictions in which it operates.
About Astral & LYPHE GROUP
Astral is a Europe focused importer and distributor of medical cannabis, and forms part of the LYPHE Group. LYPHE has developed a patient-access ecosystem, which has laid the foundations for the medical cannabis industry in the UK, and has enabled the company to become the market leader in the country's rapidly expanding market.
About Avicanna
Avicanna is an Ontario corporation focused on the development, manufacturing and commercialization of plant-derived cannabinoid-based products through its two main business segments, cultivation and research and development.
Avicanna's two majority-owned subsidiaries, Sativa Nativa S.A.S. and Santa Marta Golden Hemp S.A.S., both located in Santa Marta, Colombia are the base for Avicanna's cultivation activities. These two companies are licensed to cultivate and process cannabis for the production of cannabis extracts and purified cannabinoids including cannabidiol (CBD) and tetrahydrocannabinol (THC).
Avicanna's research and development business is primarily conducted out of Canada at its headquarters in the Johnson & Johnson Innovation Centre, JLABS @ Toronto. Avicanna's scientific team develops products, and Avicanna has also engaged the services of researchers at the Leslie Dan Faculty of Pharmacy at the University of Toronto for the purpose of optimizing and improving upon its products.
Avicanna's research and development and cultivation activities are focused on the development of its key products, including plant-derived cannabinoid pharmaceuticals, phyto-therapeutics, derma-cosmetics and Extracts (defined as plant-derived cannabinoid extracts and purified cannabinoids, including distillates and isolates), with a goal of eventually having these products manufactured and distributed through various markets.
Stay Connected
For more information about Avicanna, visit www.avicanna.com, call 1-647-243-5283, or contact Setu Purohit, President by email info@avicanna.com.
Cautionary Note Regarding Forward-Looking Information and Statements
Certain information in this press release contains forward-looking statements. Such statements include but are not limited to the source of extracts to be included in the CBMPs, the manufacturer of the CBMPs, the ability of Avicanna to import the CBMPs, the ability of Avicanna and Astral to achieve the strategic milestones contemplated in the Agreement and the ability of Avicanna to generate revenue from the Agreement. This information is based on current expectations that are subject to significant risks and uncertainties that are difficult to predict, including the risk factors set out under the heading "Risk Factors" in the Company's long form final prospectus dated July 8, 2019. Actual results might differ materially from results suggested in any forward-looking statements. The Company assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those reflected in the forward-looking statements, unless and until required by securities laws applicable to the Company.
SOURCE Avicanna Inc.
African Mission Healthcare Launches Campaign
to Aid Africa’s ‘Forgotten’ War Victims
NGO provides vital ‘life support’ for only major hospital for
1.3 million people in conflict-torn Sudan’s Nuba Mountains
DELAND, Fla.—Aiming to provide vital medical help for hundreds of thousands of traumatized, but courageous and resilient victims of Sudan’s “hidden” war, U.S.-based nonprofit organization African Mission Healthcare (AMH, www.africanmissionhealthcare.org) launched a new campaign today—“Nuba 2020”— (www.Nuba2020.com) to coincide with Giving Tuesday, Dec. 3.
The Nuba 2020 campaign goal is to ensure the only major hospital in Sudan’s war-torn Nuba Mountains continues to save hundreds of thousands of children and adults threatened by conflict, disease and medical emergencies 365 days a year.
This is a once-in-a-generation opportunity to help the hurting and forgotten people of the Nuba Mountains before it’s too late,” said American missionary surgeon Dr. Tom Catena, who is leading the Nuba 2020 campaign and has been a medical missionary in Africa for nearly 20 years.
Catena—a native New Yorker and award-winning AMH-supported physician—is the only surgeon for 1.3 million people in the Nuba region, one of the poorest and most volatile places on earth. By contrast, the number of general surgeons needed to adequately serve the U.S. population is estimated to be at least seven per 100,000 people.
Shielded from much of the world, the little-known, yet catastrophic conflict in the Nuba Mountains—a region contested by the separate countries of Sudan and South Sudan—has claimed hundreds of thousands of lives and maimed and injured thousands more.
Situation Critical
Since 2008, Catena, a graduate of Duke University and former U.S. Navy doctor, has put his life on-the-line serving in war-zone Nuba, treating up to 350 patients a day—a staggering total of more than one million patients – including 2,200 direct war injuries, and saving the lives of tens of thousands of people.
During the war, most expat charity workers left, but “Dr. Tom,” as the locals call him, stayed. “I felt that if I left, I’d be saying my life was more important than theirs,” said 55-year-old Catena.
From 1983-2005, more than two million people died during the Sudanese civil war. After a six-year peace agreement, fighting erupted again in 2011, but now a tentative ceasefire is in place.
“The Nuba people are truly forgotten, caught in the center of the chaos and bombings, essentially stateless, and lacking any type of medical support from any government because they are stateless,” said Catena. “Without AMH’s support, thousands will suffer and die. We need to sustain the hospital and our network of clinics, buy new equipment and keep performing life-saving surgeries.”
In the shell-shocked Nuba region—roughly the size of Austria—Catena has kept the only major hospital in the region operating, even during bombing raids that targeted the hospital and his own home.
Against overwhelming odds, Catena and his team of local medical workers run the 435-bed Gidel Hospital and a network of six clinics, performing up to 2,000 operations, providing 53,632 hospital visits and caring for 80,000 patients at six community clinics annually on a total yearly budget of $1 million. By comparison in the U.S., the average number of general surgeries performed by male surgeons is approximately 500 cases a year.
“We’re the only facility in the Nuba Mountains where people can turn when their children’s lives are in jeopardy, they need surgery, or expectant mothers are having birth complications that too often can result in tragedy,” Catena said. Three out of every four women in the Nuba Mountains give birth without any medical assistance.
The Nuba 2020 campaign aims to raise $7.5 million to ensure the hospital and its network of clinics is able to continue its lifesaving work the next 20 years.
Nuba 2020: Keeping Hope Alive
“Without the hospital and clinics, hundreds of thousands of lives would be in peril,” said Catena. “But so many lives can be saved through essential medical care, and routine surgeries such as C-sections, that most Americans take for granted.”
While surgeries and hospital stays in the United States can cost tens of thousands of dollars, the same operations at Gidel Hospital cost a fraction of that. Further, according to Glassdoor, the average monthly salary for a U.S. nurse is approximately $6,000, compared to a nurse’s monthly paycheck in this region of just $265. The hospital relies entirely on charitable donations to cover costs.
“There are very few places on earth where so much can be achieved—and so many lives can be saved—with so little,” said Catena.
African Mission Healthcare (AMH, www.africanmissionhealthcare.org) is a Florida-based nonprofit organization, which strengthens African mission hospitals to aid those in greatest need. AMH strategically partners with mission hospitals to support and advance their commitment to provide compassionate, quality medical care to the forgotten and hurting people of Africa, and to improve the health system in sub-Saharan Africa. AMH was co-founded in 2010 by entrepreneur and philanthropist Mark Gerson and medical missionary Dr. Jon Fielder, who were college roommates.
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Annual Miles Matching Week That Doubles the Value of Donated Miles to Help Sick Children is Now Open
Until December 8, Aeroplan Miles donated to the Air Canada Foundation will be matched to help transport sick children for medical care they need away from home
Attn. video editors: See how the Air Canada Foundation's Hospital Transportation Program makes a difference in the lives of sick children needing to travel for medical care through Beckett's story: https://youtu.be/hOpbr5q51TU
MONTREAL, Dec. 3, 2019 /CNW Telbec/ - The annual Aeroplan Miles Matching week in support of the Air Canada Foundation Hospital Transportation Program, which helps sick children travel to obtain specialized medial care, is now underway. Until December 8, 2019, members who donate Aeroplan miles to the Air Canada Foundation Hospital Transportation Program will double the impact of their contribution with all miles donated to be matched, up to 500,000 miles.
The Air Canada Foundation Hospital Transportation Program helps children like Beckett, a fearless Saskatchewan-born 2.5 year old, who was diagnosed at two months old with infant acute lymphoblastic leukemia, an extremely rare disese that affects only eight children in Canada each year. Following his initial nine month treatment in Toronto, Beckett needed to return for a series of follow-up specialist appointments that could not be facilitated in his home community.
"Beckett has had 807 doses of chemo, 16 surgeries, 31 blood transfusions, and spent 189 days in hospital. We had to, and still have to, travel and to have the Hospital Transportation program in place to get him to where he needs to be is the greatest gift," said Beckett's mom, Kelley.
"Each and every mile donated to the Air Canada Foundation has the power to significantly impact the lives of children and their family in this country. The ability of the Hospital Transportation Program to help children like Beckett travel for specialized medical care is made possible and attainable through the support of generous Aeroplan members," said Priscille LeBlanc, Chair of the Air Canada Foundation. "The Air Canada Foundation donates each year on average close to 10 million Aeroplan Miles to 15 pediatric hospitals across Canada which, in turn, provide flights to children who need specialized health care that is not available in their hometown."
"Any time a child and family is travelling to Shriners Hospitals for Children for assessment or surgery, as Shriners we do our utmost to diminish their stress by providing food, lodging and transportation. The Air Canada Foundation Hospital Transportation Program allows us to fly more children to the hospital and this makes a big difference in the lives of hundreds of families," said Wayne Cormier, Transportation Chairman Luxor Shriners at Shriners Hospitals for Children.
The Aeroplan Miles Matching Week in support of the Air Canada Foundation Hospital Transportation Program is on now and runs through Sunday, Dec. 8, 2019. To donate your Aeroplan Miles, please visit aircanada.com/Foundation and select the "Donate" button located on the top banner or visit the Aeroplan Donation Program on the Air Canada Foundation page.
About the Air Canada Foundation
The Air Canada Foundation, a not-for-profit organization focused on the health and well-being of children and youth, was launched in 2012. It offers both financial and in-kind support to Canadian registered charities. Core programs include the Hospital Transportation Program, which donates Aeroplan Miles to 15 pediatric hospitals across Canada, enabling sick children to access the medical care they need but which are unavailable locally. The Air Canada Foundation, in collaboration with the airline, also engages directly in fundraising activities, such as the Every Bit Counts program, which encourages Air Canada and Air Canada Rouge customers to donate loose change of all denominations aboard flights or through collection containers available in Air Canada Maple Leaf Lounges. The Foundation also offers continued support to major health-related causes that benefit Canadians and is an active participant in international humanitarian relief activity as the need arises. For more information about the Air Canada Foundation, please visit www.aircanada.com/foundation or the 2018 Corporate Sustainability Report, Citizens of the World, online at www.aircanada.com/citizensoftheworld.
Avicanna's Rho Phyto Branded Products to be Available in California
/NOT FOR DISTRIBUTION TO UNITED STATES NEWSWIRE SERVICES OR FOR DISSEMINATION IN THE UNITED STATES. ANY FAILURE TO COMPLY WITH THIS RESTRICTION MAY CONSTITUTE A VIOLATION OF UNITED STATES SECURITIES LAWS./
TORONTO, Dec. 1, 2019 /CNW/ - Avicanna Inc. ("Avicanna" or the "Company") (TSX: AVCN) (OTCQX: AVCNF) (FSE: 0NN) today announces that LC2019, Inc. ("LC2019"), the entity that holds a license to Avicanna's intellectual property in the United States, has advised Avicanna that it has entered into an agreement (the "License Agreement") with a subsidiary of Kings Garden Inc. ("Kings Garden"), a California based company, manufacturing the Kings Garden brand, with extensive experience in the cultivation, processing and manufacturing of high-end cannabis products, pursuant to which LC2019 will sub-license Avicanna's Rho PhytoTM brand and proprietary formulations (collectively, the "Rho Products") to Kings Garden.
As announced by Avicanna in its November 26, 2019 press release, Avicanna has an option to acquire all of the outstanding shares of LC2019, which option may be exercised by Avicanna at any time and is expected to be exercised upon cannabis cultivation, processing, distribution and possession becoming federally legal in the United States.
Under the terms of the License Agreement, LC2019, through a wholly-owned subsidiary, has provided the Kings Garden team with an exclusive license to use the Rho Phyto trademark and to manufacture, market, distribute and sell the Rho Phyto advanced formulation products in the State of California. In consideration of the license granted under the License Agreement, the Kings Garden team has agreed to pay to LC2019 a royalty equal to 40% of the net profits from the sale of the Rho Products. Kings Garden, through its licensed subsidiary, will produce, manufacture and sell the Rho Products in the State of California. The initial term of the License Agreement is three years.
"We are thrilled to see the Rho Phyto brand and advanced cannabis product offerings have their initial launch in the State of California which represents the largest and one of the most sophisticated consumer markets in the world. We are also excited that the LC2019 team has decided to partner with the Kings Garden team which have demonstrated industry leading products, quality and execution. We hope that this launch in California will provide the Rho Phyto brand with a foothold in the US market place, help establish a leading global brand and attain both market information and efficacy data around the proprietary product lines," stated Aras Azadian, Chief Executive Officer of Avicanna.
About Avicanna
Avicanna is an Ontario corporation focused on the development, manufacturing and commercialization of plant-derived cannabinoid-based products through its two main business segments, cultivation and research and development.
Avicanna's two majority-owned subsidiaries, Sativa Nativa S.A.S. and Santa Marta Golden Hemp S.A.S., both located in Santa Marta, Colombia are the base for Avicanna's cultivation activities. These two companies are licensed to cultivate and process cannabis for the production of cannabis extracts and purified cannabinoids including cannabidiol (CBD) and tetrahydrocannabinol (THC).
Avicanna's research and development business is primarily conducted out of Canada at its headquarters in the Johnson & Johnson Innovation Centre, JLABS @ Toronto. Avicanna's scientific team develops products, and Avicanna has also engaged the services of researchers at the Leslie Dan Faculty of Pharmacy at the University of Toronto for the purpose of optimizing and improving upon its products.
Avicanna's research and development and cultivation activities are focused on the development of its key products, including plant-derived cannabinoid pharmaceuticals, phyto-therapeutics, derma-cosmetics and Extracts (defined as plant-derived cannabinoid extracts and purified cannabinoids, including distillates and isolates), with a goal of eventually having these products manufactured and distributed through various markets.
Stay Connected
For more information about Avicanna, visit www.avicanna.com, call 1-647-243-5283, or contact Setu Purohit, President by email info@avicanna.com.
Cautionary Note Regarding Forward-Looking Information and Statements
Certain information in this press release contains forward-looking statements. Such statements include but are not limited to the timing of the exercise by Avicanna of its option to acquire all of the shares of LC2019 and the successful commercialization of the Rho Products in California. This information is based on current expectations that are subject to significant risks and uncertainties that are difficult to predict, including the risk factors set out under the heading "Risk Factors" in the Company's long form final prospectus dated July 8, 2019. Actual results might differ materially from results suggested in any forward-looking statements. The Company assumes no obligation to update the forward-looking statements, or to update the reasons why actual results could differ from those reflected in the forward-looking statements, unless and until required by securities laws applicable to the Company.
SOURCE Avicanna Inc.
MIGHTY SELF LAUNCHES NEW CBD-BASED NEUTRACEUTICAL
SAN FRANCISCO, CALIF. (2020)—This year, Mighty Self, a health and wellness company that creates science-backed products formulated to help people sustain and enhance mental and physical health by harnessing the power of cannabinoids is launching BALANCE, a nutraceutical product that is designed to support the human body’s natural inflammatory response as well as help calm nervous tension. BALANCE is formulated with full-spectrum whole plant hemp-based CBD extract in combination with complimentary bioactive and apoptogenic herbs that assist in the body’s processes to boost mood, calm the mind, and relieve nervous tension. Made from specially selected domestic hemp, BALANCE is non-intoxicating and contains less than .03% THC (as mandated by the federal requirements of the 2018 Farm Bill).
Research for the product was based on studies that have found that the endocannabinoid system is made up of a network of receptor sites on cell membranes throughout the body. These cannabinoids behave as chemical activators that fit into those sites (CB1 & CB2). CB1 receptors are found predominately in the brain and central nervous system, and CB2 receptors in immune system cells and, to a lesser extent, in the brain.
Key ingredients in BALANCE include:CBD—CBD is a non-psychoactive compound found in the female cannabis plant that increases the levels of a naturally occurring cannabinoid in the brain called anadamide, which helps to regulate serotonin and dopamine, the neurotransmitters that trigger emotions. Preliminary studies have shown CBD to support a healthy inflammatory response, promote a feeling of relaxation, and maintain nervous system function in the body.Phenethylamine (PEA)—PEA is an organic compound that is found in foods like chocolate, beans and nuts that acts as a neurotransmitter in the body and has been shown to support focus and clarity, and promote a mood of wellbeing. Science has revealed that these results are due to the ability of PEA to reduce uptake and increase efflux of serotonin, dopamine and norepinephrine in the body.Hordenine—Hordenine is an alkaloid that naturally occurs in many plant foods (particularly barley). It has been suggested that hordenine may promote energy and focus due to its adrenergic properties, which cause nerve cells to release the neurotransmitters epinephrine and norepinephrine.DL-Phenylalanine (DLPA)—DLPA is a combination of D- and L- isomers of the amino acid phenylalanine. Phenylalanine can be converted into tyrosine, which is used to synthesize dopamine, epinephrine and norepinephrine, which can support mental alertness and focus when the body is under stressful conditions.Ashwagandha—Ashwagandha is an ayurvedic herb that has been used as an adaptogen for restoring physical and mental energy, especially when under daily stress. The ingredient has been shown to balance cortisol levels by mimicking the inhibitory neurotransmitter GABA. It has also been studied for its immune-activating effect and nootropic potential.Theobromine—Theobromine is a flavanol antioxidant compound found in the cacao bean which stimulates the nervous system with effects similar to caffeine. Studies have shown that the compound can increase mental function in older adults and has the ability to act on brain neurotransmitters to improve mood and increase energy.Curcumin—Curcumin is a compound found in turmeric. It is one of the most extensively investigated compounds of natural origin with many studies validating its role in promoting a healthy inflammatory response, antioxidant activity, and cell protection. Neurological tissue is particularly susceptible to oxidative stress, and curcumin has been shown to inhibit expression of COX-2 enzymes in the body’s inflammatory process. Mighty Self Balance is non-psychoactive, contains no artificial flavors, is sugar free and each bottle contains 25 capsules (suggested usage is one capsule per day). It is available at a retail price of $39.95 atmightycbd.co, where you can find more information about the brand.###About Mighty Self Mighty Self is a bioceutical company that creates science-based products formulated to help people sustain and enhance mental and physical health by harnessing the power of cannabinoids combined with other biologically active ingredients. As part of its adherence to ethical standards dedicated to increased wellbeing and health consciousness, the brand communicates with consumers under a policy of full transparency regarding ingredients used in its formulations and the sustainability of its processes in the development and manufacture of its products. The brand’s motto is “Health is the new wealth.” And every effort that is undertaken by Mighty Self is intended to contribute to a culture of increased health consciousness and personal improvement in the lives of everyone.
(These statements have not been evaluated by the Food and Drug Administration. Mighty Self products are not intended to medically diagnose, treat, cure, or prevent any disease.)
A self-repair guide for common holiday setbacks
Whether you’re panic shopping, bloated from too much partying, trying to maintain your holiday stamina, or struggling to get off the couch, the common cure is, always, exercise.
Gareth Nock, national team training specialist with GoodLife Fitness says just a bit of time spent moving can boost energy, improve your self-confidence and help alleviate stress when you most need it. Here are some self-repair workout tips and ideas to help you bypass common holiday health setbacks.
Bloated from the buffet A steady diet of cocktails and canapes can leave you feeling full, puffy and uncomfortable – mostly from water retention. The key is to drink lots of water and fit in cardio workout moves to sweat out the toxins. Exercise helps your body use excess water and shifts a lot of water into your muscles, which can reduce the puffy look and feel caused by retaining water.
Try some cardio. Jump on the elliptical for 30 minutes or enjoy a bike ride or a brisk walk to get sweating and sped up digestion. Yoga moves like a torso twist, elongated triangle, sphinx and cat-cow are also good to work muscles and get your gut working normally again, as well as reduce puffiness.
Not enough sleep Back-to-back holiday parties, late nights spent wrapping, plus shopping, holiday concerts, cooking and more can leave you exhausted. Unfortunately, it feels like there’s never enough time to sleep during the holiday countdown. It seems counterintuitive, but when you’re tired exercise is a great solution. Research shows people who complain of fatigue could increase their energy by 20 percent and decrease fatigue by as much as 65 percent by simply participating in regular low-intensity exercise.
Some great workouts for when you’re tired include incline walking or a light jog, pilates, dynamic stretching, or a group fitness class that will boost energy and morale.
Feeling the pressure It’s the most wonderful time of the year, but for many, the pressures of the holidays can be stressful. Family visits, battling crowds at shopping malls, filling an endless ‘to do’ list can take away your Holiday Zen.
Working out is a perfect way to vent negative energy and minimize the effects of stress. When you exercise, your body reduces stress hormones like cortisol and increases the production of feel-good hormones (endorphins). A good workout can clear your mind and gets the blood flowing. It improves sleep and helps with digestion. Deep breathing, stretching, yoga, or a cardio session can make all the difference. Lifting weights for some strength training moves can help you vent extra stress energy.
Lost your motivation For many people, the holidays prompt the urge to lounge on the couch....sometimes for days. The longer you leave it, the more difficult it is to return to the gym. The key is to remind yourself of the benefits. Exercise can help increase your energy and decrease your appetite. There is a sense of accomplishment during the holiday season. You look better and your confidence increases.
The best exercises to boost motivation and energy are ones you enjoy. Try something new, like martial arts or a dance-inspired fitness class. Or get outside and enjoy skating, hiking or a run. Plan your workout around potential wins and set achievable goals to stay motivated.
You need a healthy party glow – right NOW Feeling a bit wilted after work? Try fitting in a quick workout at the gym or even at your desk to get your second wind and hit the town. For a quick sweat-free sculpting workout, try squats, lunges, planks, tricep dips and push-ups to improve posture, muscle tone and get your glow on.
Finding time to visit with friends Instead of hitting the pub for nachos, consider meeting up for a run or hitting a yoga class together. The opportunity to catch up while exercising is a productive way to use your time together. You’ll be able to challenge and motivate each other while benefiting from the feel-good endorphins that happen when you sweat together.
Not sure how to start your fitness resolutions? Instead of waiting for after the new year to re-start your fitness routine, why not use the extra time over the holidays to get a head start? Build in some gym time while work and routine are slower. It’s better to gradually increase your activity so you’re already underway when January 1 hits.
TORONTO, Nov. 29, 2019 /CNW/ - Canada Health Infoway (Infoway) and EndoSoft LLC (EndoSoft) announced today that the EndoVault v3.x solution has achieved Infoway certification under the 2017 Edition of pre-implementation certification requirements.
"We congratulate EndoSoft for achieving Infoway Certification as an ambulatory electronic medical record (aEMR), approved for deployment at customer sites," said Mark Nenadovic, Senior Director, Programs & Alliances, Infoway. "This achievement ensures that the company's solution conforms to the national and international standards for privacy and security."
EndoSoft's offering, EndoVault, is a market leading EMR solution developed with more than 25 years of expertise. EndoSoft is dedicated to enhancing interoperability and improving patient care through its applications.
"EndoSoft is proud that EndoVault 3.x has achieved Infoway Certification for our ambulatory EMR," said Rakesh K Madan, President & CEO, EndoSoft. "It highlights our commitment to ensuring that we meet the highest standards for all of our health care solutions, including standards for privacy and security."
Infoway Certification provides assurance that digital health software complies with specified requirements and standards, which helps ensure the protection of personal health information. The 2017 Edition requirements build upon Infoway's original certification requirements and are harmonized to increase alignment between Infoway, provincial requirements and international standards, and to reduce testing redundancies.
About EndoSoft
From a solo provider's practice to large multi-specialty hospital systems, EndoSoft applications are used by more than 50,000 clinical users worldwide and the company has become one of the most trusted names in healthcare technology.EndoSoft's offerings include EndoVault, a market leading EMR that boasts a multitude of specialties including Gastroenterology Endoscopy, ENT, OB/GYN, Pathology, Orthopedics, Cardiology, Pain Management, Pulmonology, Oncology, Ophthalmology, Dermatology and Urology, just to name a few along with modules for Nursing, Infusion, scheduling and inventory management. EndoVault is also compliant with multiple international standards including meaningful use and IHE. Visit www.endosoft.com.
About Canada Health Infoway
Infoway helps to improve the health of Canadians by working with partners to accelerate the development, adoption and effective use of digital health across Canada. Through our investments, we help deliver better quality and access to care and more efficient delivery of health services for patients and clinicians. Infoway is an independent, not-for-profit organization funded by the federal government. Visit www.infoway.ca.
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