New Treatment Option Now Available in Canada for Newly Diagnosed Patients with Advanced Lung Cancer
KEYTRUDA® (pembrolizumab) in Combination with Pemetrexed and Platinum Chemotherapy Reduced the Risk of Death by Half Compared to Chemotherapy Alone
Every day, approximately 78 Canadians are diagnosed with lung cancer and 58 die from iti
Non-small cell lung cancer (NSCLC) is the most common form of lung cancer, making up 80 to 85 per cent of all casesii
The five-year survival rate for advanced NSCLC is currently estimated to be 2 to 13 per centiii
KIRKLAND, QC, March 18, 2019 /CNW/ - Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that Health Canada has expanded the label for KEYTRUDA® (pembrolizumab), Merck's anti-PD-1 therapy, to include approval for the treatment of metastatic non-squamous NSCLC, in combination with pemetrexed and platinum chemotherapy, in adults with no EGFR or ALK genomic tumour aberrations, and no prior systemic chemotherapy treatment for metastatic NSCLC.
"Lung cancer is the deadliest form of cancer in Canada. It is vital that we continue to develop new approaches to treating this, sadly, too common disease," said Dr. Normand Blais, medical oncologist at the Centre Hospitalier Universitaire de Montréal. "Immuno-oncology therapies are changing the way we treat lung cancer in Canada and helping to change survival expectations for these patients."
In the pivotal, Phase 3 KEYNOTE-189 trial of patients regardless of PD-L1 tumour expression status, KEYTRUDA®, in combination with pemetrexed and platinum chemotherapy, demonstrated a statistically significant and clinically meaningful improvement in overall survival (OS) (HR=0.49 [95% CI, 0.38-0.64]; p<0.00001), reducing the risk of death by half compared to chemotherapy alone. The study also showed a significant improvement in progression-free survival (PFS) compared to chemotherapy alone (HR=0.52 [95% CI, 0.43-0.64]; p<0.00001).iv
Changing survival expectations "When I first learned I had metastatic lung cancer, I was devastated. Like most people diagnosed with this disease, it is at a late stage and the prognosis was poor," said Larry Frydman, a Toronto lung cancer survivor. "I quickly learned that science was in overdrive. Today's news of new innovative treatment options brings much needed hope to Canadians living with lung cancer."
"Health Canada's decision means that Canadians living with lung cancer will have a new tool to fight this disease," said Shem Singh, Executive Director of Lung Cancer Canada. "This is important as innovative treatment options provide metastatic lung cancer patients with the possibility of improved outcomes and the hope for more time with family and loved ones."
About Lung Cancer Lung cancer, which forms in the tissues of the lungsv, usually within cells lining the air passages, is the leading cause of cancer death worldwide.vi Each year, more people die of lung cancer than die of colon and breast cancers combined.vii The two main types of lung cancer are non-small-cell and small-cell. NSCLC is the most common type of lung cancer, accounting for 80 to 85 percent of all cases.viii The five-year relative survival rate for patients suffering from highly advanced, metastatic (Stage IV) lung cancers is estimated to be between 2 and 13 per cent.ix
Lung cancer is the most commonly diagnosed cancer in Canada (excluding non-melanoma skin cancers).x It is the leading cause of death from cancer for both men and women in Canada. In 2017, an estimated 28,600 Canadians were diagnosed with lung cancer; representing 14 per cent of all new cancer cases, and 21,100 Canadians died from lung cancer, representing 26 per cent of all cancer deaths.xi
About KEYTRUDA® KEYTRUDA® is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumour cells. KEYTRUDA® is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumour cells and healthy cells.
KEYTRUDA® was first approved in Canada in 2015 and currently has eight indications in a number of disease areas, including non-small cell lung cancer, classical Hodgkin lymphoma, melanoma and bladder cancer.
Merck has the industry's largest immuno-oncology clinical research program. There are currently more than 750 trials studying pembrolizumab across a wide variety of cancers and treatment settings. This clinical program seeks to understand the role of pembrolizumab across cancers and the factors that may predict a patient's likelihood of benefitting from treatment with this medication, including exploring several different biomarkers.
Our Focus on Cancer Our goal is to translate breakthrough science into innovative oncology medicines to help people with cancer worldwide. At Merck Oncology, helping people fight cancer is our passion and supporting accessibility to our cancer medicines is our commitment. Our focus is on pursuing research in immuno-oncology and we are accelerating every step in the journey – from lab to clinic – to potentially bring new hope to people with cancer.
About Merck Canada For over a century, Merck, a leading global biopharmaceutical company known as MSD outside of the United States and Canada, has been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Through our prescription medicines, vaccines, biologic therapies and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to health care through far-reaching policies, programs and partnerships.
Today, Merck continues to be at the forefront of research to advance the prevention and treatment of diseases that threaten people and communities around the world – including cancer, cardio-metabolic diseases, emerging animal diseases, Alzheimer's disease and infectious diseases including HIV and Ebola. For more information about our operations in Canada, visit www.merck.ca and connect with us on YouTube and Twitter @MerckCanada.
Forward-Looking Statement of Merck & Co. Inc., Kenilworth, NJ, USA This news release of Merck & Co., Inc., Kenilworth, N.J., USA (the "company") includes "forward-looking statements" within the meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. These statements are based upon the current beliefs and expectations of the company's management and are subject to significant risks and uncertainties. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements.
Risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining regulatory approval; the company's ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the company's patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions.
The company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in the company's 2017 Annual Report on Form 10-K and the company's other filings with the Securities and Exchange Commission (SEC) available at the SEC's Internet site (www.sec.gov).
Peanuts Integral to MIND Diet and Brain Health New Study Finds MIND Diet Associated with Reduced Incidence and Delayed Progression of Parkinson’s
Albany, Ga. (March 15, 2019) – A recent study published in the journal Nutrition, Health & Aging found the MIND diet, which was specifically developed as a dietary pattern to prevent cognitive decline, can reduce and delay the progression of Parkinson’s disease. Previous research has shown the MIND diet may also reduce the risk of developing Alzheimer's disease by as much as 53 percent.
The MIND diet is a daily eating pattern that combines elements from the heavily researched Mediterranean and DASH (Dietary Approaches to Stop Hypertension) diets. The MIND diet recommends Americans structure their eating around 10 brain-healthy food groups to improve brain function and prevent dementia. The food categories include green leafy vegetables and other vegetables, nuts, berries, beans, whole grains, fish, poultry, olive oil and a small amount of wine a day.
“I consider the MIND diet very approachable and sustainable because it offers flexibility and variety. For example, you don’t have to eat berries everyday—just twice per week. And, if you’re tired of strawberries, try blueberries,” says Dr. Samara Sterling, director of research for The Peanut Institute. “To reach the five servings of nuts per week that are recommended, you can have a peanut butter sandwich on whole grain bread or grab a handful of peanuts as a snack. Peanuts are a healthy, convenient and affordable way to hit that MIND target.”
Peanuts are also a stand-out because they contain high levels of niacin and are a good source of vitamin E – two nutrients that have long been known to protect against Alzheimer’s disease and age-related cognitive decline.Plus, they’re packed with protein and 19 vitamins and minerals, making them a true superfood.
To meet the MIND diet guidelines, Dr. Sterling suggests eating a handful of peanuts or two tablespoons of peanut butter almost every day.
In addition to the MIND diet recommendations, peanuts are being highlighted in many scientific studies as researchers focus more and more on the impact dietary patterns have on chronic disease prevention.
“People who eat peanuts regularly have a lower risk of heart disease; and there is growing evidence that the risk of developing Alzheimer’s disease is associated with risk of cardiovascular disease,” says Dr. Frank Sacks, professor of cardiovascular disease prevention, department of nutrition, Harvard T.H. Chan School of Public Health. “We surmise that peanuts could be an important component of a diet that prevents cognitive decline with aging. That is one reason why we included peanuts in the MIND study.”
According to Dr. Sterling, the foods that are emphasized in the MIND diet are nutrient-dense and plant-based.
“Vegetables, whole grains and nuts are filled with vitamins, minerals and antioxidants that are not only beneficial for the brain, but for the entire body as well. So, adherence to the MIND diet can help a person get these and other nutrients in their diet,” says Sterling.
Dr. Samara Sterling is a Nutrition Scientist with expertise in the use of plant-based nutrition for the prevention and treatment of chronic diseases. She currently serves as the Research Director for The Peanut Institute and has also worked as a nutrition consultant for various community-based nutrition projects. She holds a bachelor’s degree from Stony Brook University, a master’s degree from Andrews University and a Ph.D. from the University of Alabama at Birmingham. Based in Albany, Ga., The Peanut Institute is a non-profit organization supporting nutrition research and developing educational programs to encourage healthful lifestyles that include peanuts and peanut products. The Peanut Institute pursues its mission through research programs, educational initiatives and the promotion of healthful lifestyles to consumers of all ages. As an independent forum, The Peanut Institute is uniquely positioned to work with all segments of the food industry, the research community, academia, consumer organizations and governmental institutions.
References
Agarwal, P., et al., MIND Diet Associated with Reduced Incidence and Delayed Progression of ParkinsonismA in Old Age. J Nutr Health Aging, 2018. 22(10): p. 1211-1215.
Chen, X., et al., Dietary Patterns and Cognitive Health in Older Adults: A Systematic Review. J Alzheimers Dis, 2019. 67(2): p. 583-619.
Shoppers Drug Mart continues to support front-line fight against Canada's opioid epidemic
TORONTO, March 15, 2019 /CNW/ - Canada is facing an opioid crisis, which continues to cause significant harm to many Canadians. Today, Shoppers Drug Mart, and its parent company Loblaw Companies Limited, reaffirmed their longstanding commitment to the front-line fight against the opioid epidemic by releasing a comprehensive strategy to build on the existing efforts taken by their more than 1,700 pharmacy teams across the country in their ongoing fight to help to address this crisis and help save lives.
"This is a problem in nearly every neighbourhood, affecting our patients, customers, friends and family members. We want to be a positive force for change, as we continue to support the front-line fight against Canada's opioid epidemic," said Jeff Leger, President, Shoppers Drug Mart. "Over the past few years, our pharmacy teams have been called upon to help more and more patients struggling with opioid addiction. Today's announcement represents a concerted effort to build upon our existing work and ensure that our efforts are having the most meaningful impact possible."
Shoppers Drug Mart is reinforcing its support strategy with a renewed focus on the following comprehensive five-pillared approach:
Promoting Appropriate Use through detection tools and ongoing management of patients' opioid use.
Empowering Pharmacists through continuing education, clinical practice tools, and narcotic monitoring and pharmacy systems for a holistic approach to patient care.
Optimizing Therapy by managing patients' treatment and conducting pain management assessments or medication reviews when appropriate and supporting advocacy efforts to limit quantities dispensed.
Providing Pharmacy Treatment and Rescue Options by ensuring broad access to treatment for opioid dependence, alternate options for pain management, and naloxone kits through our pharmacies.
Building a Community of Support by improving access to community resources and driving fundraising and program development support.
"We are committed to identifying innovative ways in which we can continue to contribute to fighting this crisis and are encouraged by the increased awareness and focus from all stakeholders," said Leger. "We continue to advocate for government support, specifically to include pharmacists as practitioners within the Controlled Drugs and Substances Act, which would allow them to adapt prescriptions to ensure patients receive the safest and most effective therapy for their specific need."
Additionally, Shoppers Drug Mart is committed to working collaboratively with all key stakeholders, including government, physicians, payors and professional associations, to curb the surge in opioid-related deaths. Shoppers Drug Mart will host a series of community town halls across the country, bringing together community members with key healthcare stakeholders to discuss actionable outcomes for local impact.
About Shoppers Drug Mart Shoppers Drug Mart is one of the most recognized and trusted names in Canadian retailing. The company is the licensor of full-service retail drug stores operating under the name Shoppers Drug Mart (Pharmaprix in Québec). With almost 1,300 Shoppers Drug Mart and Pharmaprix stores operating in prime locations in each province and two territories, the company is one of the most convenient retailers in Canada. The company also licenses or owns 47 medical clinic pharmacies operating under the name Shoppers Simply Pharmacy (Pharmaprix Simplement Santé in Québec), and provides cosmetic dermatology services at one standalone location, the Beauty Clinic by Shoppers Drug Mart. As well, the company owns and operates 36 corporate Shoppers Home Healthcare stores, seven Wellwise by Shoppers Drug Mart stores and an ecommerce site Wellwise.ca, making it the largest Canadian retailer of home health care products and services. In addition to its retail store network, the company owns Shoppers Drug Mart Specialty Health Network Inc., a provider of specialty drug distribution, pharmacy and comprehensive patient support services, and MediSystem Inc., a provider of pharmaceutical products and services to long-term care facilities. Shoppers Drug Mart is an independent operating division of Loblaw Companies Limited.
SOURCE Shoppers Drug Mart
The 5 Biggest Disruptors
Wreaking Havoc On Your Hormones
As 2019 dawns, some people are taking a “new year-new you” approach. They’re determined to make self-improvements that provide a fresh, positive outlook and strong sense of well-being.
But sometimes health factors undermine those good intentions, such as depression and its link to hormone imbalances. There are myriad ways both men and women suffer adverse effects to their hormones, says Don Colbert, M.D., and many of them are avoidable.
“We are exposed to thousands of toxic chemicals on a regular basis in the air, water and food,” says Colbert (https://drcolbert.com), author of Dr. Colbert's Hormone Health Zone. “Some of them are hormone disruptors because they disturb your endocrine system, wreaking havoc and creating hormonal imbalances.
“Not only are the effects of all these disruptors depressing to think about; they actually cause depression, along with countless other ailments such as type 2 diabetes, high blood pressure, heart disease, obesity and more. But the basic principle is this: decreasing the number of disruptions will improve your health.”
Dr. Colbert breaks down the top hormone disruptors affecting men and women along with ways to minimize the disruption or stop it:
Lifestyle choices. “Whether it’s weight gain and a lack of exercise, anger and unforgiveness, drinking too much alcohol or some other thing that can be controlled, your hormone levels drop and you begin a slow slide to poorer health,” Dr. Colbert says. “Make better choices, and that dramatically decreases the chances of having any hormone deficiency symptoms.”
Medications. Medications affect the body’s cells, and sometimes side effects manifest in major problems. For example, Dr. Colbert cites Mayo Clinic research showing a prescription statin drug that lowered cholesterol could result in liver damage, memory loss or type 2 diabetes. “I estimate that 55 percent of the entire US population is taking pills that directly and negatively affect hormone levels,” Dr. Colbert says. “Get off these harmful medications you hate.”
Things you touch. Chemicals entering the body through the skin can cause long-term damage. Dr. Colbert notes phthalates, disruptors found in household cleaners, cosmetics, toys and numerous other products. “Phthalates negatively affect both men’s and women’s ability to use the testosterone that is in our bodies,” Dr. Colbert says. “Another is BPA (bisphenol A), found on the inside of metal-canned foods and plastic food-storing containers. Specifically, BPA has been found to cause or contribute to cancer, fertility problems, developmental issues and heart disease. I recommend buying glass jars of food and storing in ceramic containers.”
Diet deficiencies. “The standard American diet is usually low in key nutrients that support a healthy thyroid,” Dr. Colbert says. “Many patients with hormone imbalances have low iodine. The best solution is eat more vegetables, ideally raw or steamed.”
Aging. Dr. Colbert says estrogen levels for women begin to decline around the age of 50; for men, testosterone levels can drop low around age 45-50. “Aging is a natural combatant as a hormone disruptor,” he says, “but we can slow the acceleration of the effects of aging by optimizing our hormones. Healthy habits can make a huge difference.”
“Symptoms of serious problems indicated by hormonal imbalance can be reversed by those who focus on health in their diet, lifestyle and living environment,” Dr. Colbert says. “Then they can enable all of their systems to function optimally.”
About Don Colbert, M.D.
Don Colbert, M.D. (https://drcolbert.com), is the author of Dr. Colbert's Hormone Health Zone. He has been a board-certified family practice doctor for more than 25 years and has offices in Orlando, Fla., and Dallas. The author of over 40 books, he wrote two New York Times best-sellers - The Seven Pillars of Health and Dr. Colbert’s “I Can Do This” Diet - has sold more than 10 million books and treated 50,000-plus patients. Dr. Colbert is a frequent show guest of Christian leaders Joyce Meyer, John Hagee, and Kenneth Copeland and has been featured on The Dr. Oz Show, Fox News, ABC World News Tonight, and in periodicals such as Newsweek and Reader’s Digest.
Homewood Ravensview, a Landmark Mental Health and Addiction Treatment Centre on Saanich Peninsula, Announces Opening Date of May 22
New centre to offer a combination of innovative treatment programs
VICTORIA, March 14, 2019 /CNW/ - Homewood Ravensview, part of Homewood Health, will begin providing inpatient treatment for mental health, addiction and concurrent conditions on May 22, 2019.
"When we open the doors in May," said Homewood Health president and CEO Jagoda Pike, "Homewood Ravensview will immediately become the most comprehensive private mental health and addiction treatment centre in Western Canada. We've recruited an experienced and highly credentialed team to oversee treatment programs based on 135-years of Homewood excellence combined with the latest in evidence-based innovation."
Dr. Lyn MacBeath, the founding medical director at Homewood Ravensview, said, "Our programs are truly unique in Canada. Our Guardians program for first responders and members of the military – both active duty and veterans – is designed specifically for the challenges these real-life heroes face. Then we have our Cornerstone program for adults and the My Path program for young adults, each delivering evidence-based treatment with the latest innovations in care. We're also proud to launch the Vanguard program to meet the specific needs of executives and professionals."
"The diversity and quality of the treatment we provide means everything to us," Pike added, "and we also know that the work we'll do at Ravensview to help people living with addiction and mental health conditions connects to so many other important issues." She expressed particular pride for the strong partnership Homewood Health has with the Pauquachin First Nation.
Ravensview will also have a positive impact on the local economy, bringing 80 high-quality full-time jobs to the region while relieving pressure on the provincial healthcare system as it deals with, for example, the opioid crisis and growing recognition of post-traumatic stress.
The comfortable accommodations at Ravensview, along with the beauty of the forested 28-acre site with mountain and ocean views set the Ravensview experience apart as well. Before Ravensview accepts its first clients on May 22, Homewood Health is offering bridge counselling to assist people who are waiting for the programs at Homewood Ravensview to begin.
Ravensview accepts referrals from medical or healthcare professionals, but a referral is not necessary for treatment. Anyone interested in learning more about Ravensview programs or self-admission should visit ravensview.com/contact or call 1.866.203.1793.
A formal opening ceremony for Homewood Ravensview will take place in June.
About Homewood Health Homewood Health is the Canadian leader in mental health and addiction services. With more than 135 years of experience, Homewood achieves outstanding outcomes through its national network of more than 4,500 employees and clinical experts. Homewood's complete suite of services includes organizational wellness, employee and family assistance programs, assessments, outpatient and inpatient treatment, recovery management, return to work and family support services, all customized to meet the needs of individuals and organizations. Homewood Health is redefining mental health and addiction services to help Canadians live healthier, more productive and more fulfilling lives.
About Homewood Ravensview Homewood Ravensview, part of Homewood Health, offers treatment for mental health, addiction and concurrent conditions. The centre is located on 28-acres of forested hillside on Vancouver Island's Saanich Peninsula and focuses on creating individualized client experiences. Homewood Ravensview features forest and ocean views from private and semi-private bedrooms, suites and welcoming common areas. Homewood Ravensview is scheduled to open May 22, 2019 with 75 beds and will employ more than 80 full-time staff.
SOURCE Homewood Health Inc.
4 Ways to be More Comfortable While Biking
Cycling can be one of the most enjoyable forms of exercise, but it isn’t always the most comfortable activity. Unnecessary discomfort when riding can be off-putting to beginning biker and make it harder to maintain a regular biking schedule. Fortunately, there are many ways to make riding a bike easier on your body while still allowing you to get in enough exercise. These four solutions can ensure a more comfortable bike ride.
Enhanced Bike Seat
Standard bike seats can sometimes lead to soreness when sitting on them for prolonged periods of time. There are now seats on the market that have been designed to provide greater comfort. A seat made with a gel cushion will be a great addition to your bicycle. Some seats have backrests that can ease much of the strain from the back. Extra-wide seats are also available if you want some additional width and support. Comfortable seats are especially important for those who are going to be biking on rough terrain. Bumps and jolts can knock a beginning biker against their seat, causing pain and bruising that can really impact the experience for the worse. If you’re going to spend a lot of time on a bike, be sure to invest in a comfortable seat.
Shock Absorption
The shock that you feel as your bike travels over roadways and pathways can take a toll on more than just your tailbone. Rough terrain can jolt your body and cause you to experience soreness and fatigue quicker. The strain on your wrists can cause swelling and, eventually, nerve damage. On top of that, a sudden jolt can often cause bikers to bite their tongue or lip unexpectedly and painfully. With bike shock absorbers, those jolts will be absorbed by the absorption springs rather than by your arms, legs, and spine. Many of the best bike absorbers for sale are compact in size and fit easily onto most types of bicycles. If you’re going to be often biking on rough terrain, ensure that your bike is properly outfitted with shock absorbers to protect your comfort and health.
Proper Cycling Attire
Wearing the proper clothing as you cycle can give you greater comfort throughout your entire ride. Many custom cycling kits are made from breathable fabrics that feel good on the skin and contain sweat-wicking properties. This can act as a barrier between your skin and the sun while also keeping you cool The best cycling shoes are lightweight and provide adequate support without being too confining. These will ensure that your cycling motions don’t put too much strain on your ankles and arches. Gloves with padded palms make gripping the steering wheel easier on the hands and protect them from the wind. Wearing a waterproof thermal jacket on a cold day can help you stay warmer. These also act as a barrier against the wind, preventing dry skin and chills.
Attachable Mirrors and Blinkers
Looking behind you is important when turning on your bike. However, the hunched position you’re in on your bike is not ideal for craning your neck around and can actually strain your neck and back. Not every biker is experienced enough to feel comfortable taking their hands off of the handlebars to signal their turns, either. If you’re tired of craning your neck to see what’s behind you or using your arms to signal turns, mirrors and blinkers that attach to your bicycle can be an excellent investment. These accessories can make your riding experience safer and more comfortable. It’s easy to attach bicycle mirrors to your handles for better visibility. Bicycle blinkers work like car blinkers and make signaling a turn more apparent to motorists, pedestrians and other cyclists. These additions allow you to keep a firm grip on the wheel, keep your head facing forward, and your focus and balance intact.
You’ll want to make the most out of each cycling experience so that you’ll feel more encouraged to keep riding consistently. While many are turned away by the discomforts of bike riding as an exercise method, these discomforts can be mitigated. By enhancing the comfort of each cycling adventure, you’ll be have a better time enjoying your ride and even further protect your health.
Not just a Better Body: Spring into a Happier, Healthier Lifestyle
By Joshua Mansour, M.D.
As we enter into Spring and the weather improves, many people naturally think about “getting summer-ready.” They work towards eating healthier and exercise in an effort to lose some weight to be “beach-bound.” Although many people focus mainly on the aesthetics resulting from dieting, there are actually numerous health benefits including a decreased risk of cardiovascular disease, decreased risk of diabetes, and even cancer prevention that can be secondary benefits.
With the weather starting to warm up, the sun starting to shine, and the cold fronts decreasing in severity, people are now sprinting to the door to get outside. The data on the advantages of being active is far from new. The World Health Organization had written a piece greater than a decade ago warning people of the complications of a sedentary lifestyle. It has been found to be one of the top ten leading causes of death and disability in the world at that time. Physical inactivity not only increases mortality, but can severely increase the risk of several different diseases including but not limited to heart disease, high cholesterol, Diabetes Mellitus, and obesity.
Physical inactivity can also play a role and can even increase your risk of cancer. The America Cancer Society indicates that about 1/5 of all cancer deaths in the United States each year are linked to excess body weight, poor diet, excessive alcohol intake, and decreased physical activity. According to the National Cancer Institute and the Mayo Clinic, you can aid in lowering your risk of breast cancer by maintaining a healthy weight by helping decrease certain hormone levels that may play a part. An increase in hormones such as insulin and related hormones in obesity can encourage colorectal cancer. It has been shown that even by decreasing your weight by 10% can you reduce your risk of cancer. Although cellular and genetic factors that continue to be discovered play a major role, there is no denying that a healthy diet and physical activity contribute to cancer prevention.
At this time many people start thinking about losing body fat and potentially seeing the appearance of abdominal muscles and definition. There is a common saying that “abs are made in the kitchen”. Although some may be thinking about how they will look in the mirror or in front of others, eating healthy can pose several other benefits. The National Institute of Health, The American Cancer Society, The National Cancer Institute, The American Heart Association, and The National Heart and Lung Institute recommend increasing the intake of fruits and vegetables in our daily diets. Integrative medicine physician Dr. Eddie Fatakhov explains that “Eight to ten servings of fresh fruits and vegetables, along with a certain amount of whole grains, is what we should be consuming every day; however, most Americans do not even consume three to four servings daily.”
Dr. Fatakhov explains that “by consuming more grains, vegetables, and fruits we can ourselves and do our part to neutralize free radicals with antioxidants and natural substances. Additionally, increased consumption, may in cases, help to reverse the existing damage, caused by the free radicals.” Several studies have shown that nutrition can play a very important role in cancer prevention and have a significant impact on breast, colon, oral cavity, lung, prostate cancer to name a few. Eating foods such as vegetables that are loaded with antioxidants and fiber can further help dysmorphic cells from developing. While it may not be known exactly which factors have the greatest effect, the evidence is even supported by the American Cancer Society and National Cancer Institute.
Thus, there is no reason we all should not live longer lives, maintain our energy, sex drive, and other faculties throughout our entire life span by being more active and eating healthier. While different people may have different reasons for starting now, there is no better time to start than today. So, this summer when you look in the mirror smiling about your progress, know that you are making even greater strides that meet the eye, in your journey towards a happier and healthier life.
About Joshua Mansour, MD:
Dr. Joshua Mansour is a board-certified hematologist/oncologist working and in the field of hematopoietic stem cell transplantation and cellular immunotherapy in Stanford, California. Recently he has managed to have over 10 recent abstracts and over 10 recent manuscripts published in esteemed journals and given countless presentations at conferences and other institutions. He has helped design and implement clinical studies to evaluate current treatment plans, collaborated on grant proposals, and lead multi-institutional retrospective studies that have been published.
Unless you have been living under a rock, you know that smoking, not wearing sunscreen and going to bed with your makeup on hardly produces the coveted look of Instagram’s “glass skin.” Aside from these three ‘skin sins’ there are many others that are not so obvious. We turned to Denver Board-Certified Plastic Surgeon Dr. Manish Shah who is a big believer in pre-juvenation and a holistic approach to youth.
Inconsistent Dieting
“Many people think caring for your skin is skin-deep,” quips Dr. Shah. “It is not.“ Inconsistent or inadequate nutrition that has your body mass and weight moving in a yo-yo motion up and down the scale can contribute to ruined elasticity and reduced collagen in the skin. This is part of the reason why specialists will recommend a two-pound maximum weight loss goal per week because your skin needs time to adapt to the loss of mass. Dr. Shah explains that the skin needs to be nourished from the inside as well and many of the trend diets like keto and paleo focus on one group of food and though it can help keep a caloric deficit, it can also create a deficit of the necessary vitamins and minerals you need to keep your skin looking healthy.
Drinking Too Much Coffee
“Excessive amounts of caffeine can increase the levels of insulin and cortisol in the system,” explains Dr. Shah. Insulin increases inflammation and cortisol is known as the stress hormone. This combination could mix up your sleeping habits and contribute to continued stress which can lead to sleep deprivation. “Sleep deprivation prevents that regenerative rest our skin and mind need to stay healthy.”
Neglecting the Skin Around Your Eyes
"The skin around your eyes is the thinnest and has very few oil glands," says Dr. Shah. Pamper your eyes and stave off signs of aging by choosing a daily eye cream that includes peptides. Dr. Shah explains, “They work to stimulate collagen production and prevent fine lines. Be sure to check the label.” Other notable ingredients that reduce puffiness, lines, wrinkles, and under eye circles are caffeine and nicotinic acid (a form of the B vitamin niacin).
Expecting Instant Results from Beauty Treatments
Most of us are guilty of trying a face cream or anti-aging treatment once or twice and then giving up on it before it has had a chance to work. A majority of anti-aging treatments take up to a month to begin showing positive effects. Dr. Shah explains, “This is due to the cycle of your skin, which undergoes a period of cellular structure renewal over a span of 30 days. In our instant gratification mode, we often toss a product before giving it time to work.”
Taking Medications With Side-Effects on the Skin
Certain medications like corticosteroids for asthma and arthritis cause the skin to thin and weakens blood vessels. Medicine to treat seizures can cause heightened sensitivity to sun damage in the skin which is a common perpetrator in premature aging. Blood pressure medications that block calcium channels have been studied in relation to their inhibition of collagen production by obstructing the absorption of vitamin C by the cells. Vitamin C is an important part of collagen production. “If these medications are being prescribed to you by your physician then the benefits outweigh their effect on collagen production. There is no need to stress over this, as long as you take care of your skin in other ways you should be fine,” explains Dr. Shah.
Consuming Excessive Amounts of Salt
“By all measures, an excess of salt in your diet is detrimental to your kidneys, your cardiovascular health and, yes, your skin,” says Dr. Shah. Salt absorbs moisture and it can aid in making your skin look dry and less vibrant. Reducing your sodium intake and sticking to a moisturizing routine should help your skin stay healthy and smooth.
Facial Expressions
Every time you move that beautiful face, your skin wrinkles a little bit. Most of the time your face bounces back and those little wrinkles disappear once new skin cells grow.
Soap
While you may think that soap is your skin’s best friend, this is actually not the case. The reason for this is that your skin has an acid mantle which is a natural protective barrier of the skin. When you wash with soap – which is generally alkaline – it can remove this protective layer of oils and dry out the skin, eventually leading to wrinkles. Dr. Shah says that “While it is not advisable to stop washing entirely, try swapping the soap for a PH-neutral and chemical-free cleanser, and bear in mind that there is such a thing as over-cleansing your skin.”
Tugging on Your Skin While Applying or Removing Makeup
To minimize the damage to the skin around your eyes, follow these quick tips from Dr. Shah:
Use your ring finger to pat on products around your eyes, including serums, oils, moisturizers, and concealers. Your ring finger is the least likely to pull or tug at your skin.
Apply eyeliner and eyeshadow by gently closing your eyelids, rather than by pulling them taut. If you’re struggling to apply without pulling, consider investing in products that are made to apply smoothly, like cream or gel formulas.
Have patience when removing makeup from the eye area. Use cotton or another soft product, coated well with your favorite makeup removing solution. Hold the cotton over your closed eye without wiping, allowing the product to break down the makeup. After a minute or so, wipe gently to remove the makeup.
Picking Your Skin
You're not a dermatologist or licensed aesthetician. You should not be picking at your pimples, ingrown hairs, or anywhere else on your face. It's one of the biggest assaults against your skin and can have permanent effects. "The more people press and manipulate blemishes, the more inflammation they create underneath," explains Dr. Shah. "The result is scars, pockmarks, and discoloration that can become permanent.”
Licking Your Lips Constantly
There's a myth out there that claims people can get addicted to lip balm. "These people just have dry skin and miss the feeling of the balm when it's gone," says Dr. Shah. Lip licking can become a bad habit. But when you moisten your lips that way, you actually wind up making things worse. The water in your saliva evaporates, leaving lips dry and cracked. "Saliva can contain bacteria and irritants, so you can end up with a rash around the lips as well," says Dr. Shah. Try a lip balm such as Burt's Bees 100% Natural Moisturizing Lip Balm, Original Beeswax with Vitamin E & Peppermint Oil.
Dr. Shah’s specialties include revision facial aesthetic surgery, rhinoplasty (“nose reshaping”), and aesthetic surgery of the breast (breast augmentation, breast lift, breast reduction). He is, however, well-trained in all areas of aesthetic surgery.
Dr. Shah’s aim is to obtain a natural appearing transformation that complements the real you!
Dr. Shah is a Clinical Assistant Professor of Surgery at the University of Colorado Health Sciences Center. He maintains a private practice in Aesthetic Plastic Surgery in the Cherry Creek neighborhood of Denver.
Dr. Shah is a member of the American Society of Plastic Surgeons, the American Society of Aesthetic Plastic Surgery, the International Society of Aesthetic Plastic Surgery, the Rhinoplasty Society, and the European Academy of Facial Plastic Surgery.
Dr. Shah is board-certified by the American Board of Plastic Surgery.
Entertainment Industry Recommendations on Depicting Suicide One-of-a-kind collective recommendations reinforce the entertainment industry’s role in suicide prevention
The first-ever national recommendations for depicting suicide in entertainment content were released today by the National Action Alliance for Suicide Prevention (Action Alliance), the nation’s public-private partnership for suicide prevention. The recommendations aim to help members of the entertainment industry—content creators, scriptwriters, producers—tell more balanced and authentic stories involving suicide and suicide prevention. Substantial evidence shows that the way movies and other forms of entertainment media depict suicide and mental illness can have positive or harmful effects on viewers. Studies have found that the way the media covers suicide can influence behavior negatively, by contributing to increased suicidal behavior among viewers, or positively, by encouraging help-seeking and recovery. To assist the entertainment industry in promoting accurate portrayals of suicide – a key goal of the National Strategy for Suicide Prevention – the Action Alliance collaborated with the Substance Abuse and Mental Health Services Administration (SAMHSA) and the Entertainment Industries Council (EIC) to develop the recommendations, which were informed by both representatives from the entertainment industry and the suicide prevention fields. “Engaging with the entertainment industry is an important strategy to suicide prevention, “said Marie Gallo Dyak, chief executive officer, EIC. “The National Recommendations for Depicting Suicide serve as a resource for content creators to offer guidance when they are including suicide in a story. The goal is to portray the scene without presenting a visual image that can lead to unintentional consequence. The dialogue is authentic while also offering hope to those struggling.” “Our industry is in a unique position to educate, inspire, and empower,” said David McFarland, award-winning producer/writer for film & television and social impact advisor for the entertainment and sports industries. “Content creators, using the recommendations, can craft more authentic and balanced stories that can make a significant difference in the lives of people in communities across the country.” The National Recommendations for Depicting Suicide includes nine recommendations to help content creators craft stories about survival, hope, and healing:Convey that suicide is complex and often caused by multiple factors.Show that help is available.Portray characters with suicidal thoughts who do not go on to die by suicide.Connect viewers to resources.Portray everyday characters who can be a lifeline.Depict the grieving and healing process of people who lose someone to suicide.Avoid showing or describing the details about suicide methods.Consult with suicide prevention messaging experts and people with personal experience.Use nonjudgmental language. The new collective recommendations draw on suicide prevention best practices tailored for practical use by the entertainment industry. The Action Alliance will work with its many partners to continue providing information and resources—as part of its Real Stories Initiative—to help the news and entertainment sectors effectively develop news coverage and on-screen depictions that educate the public about suicide and suicide prevention. “As the tenth leading cause of death in our country, suicide takes the lives of too many,” said Assistant Secretary for Mental Health and Substance Use at U.S. Department of Health and Human Services, Dr. Elinore McCance-Katz. “We need to do all we can to raise public awareness, screen individuals and get them the care and treatment they need.” “The entertainment industry has a powerful impact on audience understanding of suicide and suicide prevention,” said Mark Weber, deputy assistant secretary for public affairs/human services at U.S. Department of Health and Human Services and Action Alliance Executive Committee member and Changing the Conversation Priority Group Lead. “The recommendations are offered as a tool to support the creative community in their efforts to tell compelling stories that can help prevent suicide.” # # # FOR NEWS MEDIA PARTNERS: Research shows that the media may influence suicide rates by the way they report on suicide. Evidence suggests that when the media tell stories of people positively coping in suicidal moments, more suicides can be prevented. We urge all members of the media working on these stories to refer to the Recommendations for Reporting on Suicide for best practices for safely and accurately reporting on suicide (such as including the National Suicide Prevention Lifeline 800-273-TALK [8255]). For stories of persons with lived experience of suicidality and finding hope, refer to www.lifelineforattemptsurvivors.org. NATIONAL ACTION ALLIANCE FOR SUICIDE PREVENTION: The National Action Alliance for Suicide Prevention is the public-private partnership working to advance the National Strategy for Suicide Prevention and make suicide prevention a national priority. The Substance Abuse and Mental Health Services Administration provides funding to EDC to operate and manage the Secretariat for the Action Alliance, which launched in 2010. Learn more at theActionAlliance.org, and join the conversation on suicide prevention by following the Action Alliance on Facebook, Twitter, LinkedIn, and YouTube.
Unless you have been living under a rock, you know that smoking, not wearing sunscreen and going to bed with your makeup on hardly produces the coveted look of Instagram’s “glass skin.” Aside from these three ‘skin sins’ there are many others that are not so obvious. We turned to Denver Board-Certified Plastic Surgeon Dr. Manish Shah who is a big believer in pre-juvenation and a holistic approach to youth.
Inconsistent Dieting
“Many people think caring for your skin is skin-deep,” quips Dr. Shah. “It is not.“ Inconsistent or inadequate nutrition that has your body mass and weight moving in a yo-yo motion up and down the scale can contribute to ruined elasticity and reduced collagen in the skin. This is part of the reason why specialists will recommend a two-pound maximum weight loss goal per week because your skin needs time to adapt to the loss of mass. Dr. Shah explains that the skin needs to be nourished from the inside as well and many of the trend diets like keto and paleo focus on one group of food and though it can help keep a caloric deficit, it can also create a deficit of the necessary vitamins and minerals you need to keep your skin looking healthy.
Drinking Too Much Coffee
“Excessive amounts of caffeine can increase the levels of insulin and cortisol in the system,” explains Dr. Shah. Insulin increases inflammation and cortisol is known as the stress hormone. This combination could mix up your sleeping habits and contribute to continued stress which can lead to sleep deprivation. “Sleep deprivation prevents that regenerative rest our skin and mind need to stay healthy.”
Neglecting the Skin Around Your Eyes
"The skin around your eyes is the thinnest and has very few oil glands," says Dr. Shah. Pamper your eyes and stave off signs of aging by choosing a daily eye cream that includes peptides. Dr. Shah explains, “They work to stimulate collagen production and prevent fine lines. Be sure to check the label.” Other notable ingredients that reduce puffiness, lines, wrinkles, and under eye circles are caffeine and nicotinic acid (a form of the B vitamin niacin).
Expecting Instant Results from Beauty Treatments
Most of us are guilty of trying a face cream or anti-aging treatment once or twice and then giving up on it before it has had a chance to work. A majority of anti-aging treatments take up to a month to begin showing positive effects. Dr. Shah explains, “This is due to the cycle of your skin, which undergoes a period of cellular structure renewal over a span of 30 days. In our instant gratification mode, we often toss a product before giving it time to work.”
Taking Medications With Side-Effects on the Skin
Certain medications like corticosteroids for asthma and arthritis cause the skin to thin and weakens blood vessels. Medicine to treat seizures can cause heightened sensitivity to sun damage in the skin which is a common perpetrator in premature aging. Blood pressure medications that block calcium channels have been studied in relation to their inhibition of collagen production by obstructing the absorption of vitamin C by the cells. Vitamin C is an important part of collagen production. “If these medications are being prescribed to you by your physician then the benefits outweigh their effect on collagen production. There is no need to stress over this, as long as you take care of your skin in other ways you should be fine,” explains Dr. Shah.
Consuming Excessive Amounts of Salt
“By all measures, an excess of salt in your diet is detrimental to your kidneys, your cardiovascular health and, yes, your skin,” says Dr. Shah. Salt absorbs moisture and it can aid in making your skin look dry and less vibrant. Reducing your sodium intake and sticking to a moisturizing routine should help your skin stay healthy and smooth.
Facial Expressions
Every time you move that beautiful face, your skin wrinkles a little bit. Most of the time your face bounces back and those little wrinkles disappear once new skin cells grow.
Soap
While you may think that soap is your skin’s best friend, this is actually not the case. The reason for this is that your skin has an acid mantle which is a natural protective barrier of the skin. When you wash with soap – which is generally alkaline – it can remove this protective layer of oils and dry out the skin, eventually leading to wrinkles. Dr. Shah says that “While it is not advisable to stop washing entirely, try swapping the soap for a PH-neutral and chemical-free cleanser, and bear in mind that there is such a thing as over-cleansing your skin.”
Tugging on Your Skin While Applying or Removing Makeup
To minimize the damage to the skin around your eyes, follow these quick tips from Dr. Shah:
Use your ring finger to pat on products around your eyes, including serums, oils, moisturizers, and concealers. Your ring finger is the least likely to pull or tug at your skin.
Apply eyeliner and eyeshadow by gently closing your eyelids, rather than by pulling them taut. If you’re struggling to apply without pulling, consider investing in products that are made to apply smoothly, like cream or gel formulas.
Have patience when removing makeup from the eye area. Use cotton or another soft product, coated well with your favorite makeup removing solution. Hold the cotton over your closed eye without wiping, allowing the product to break down the makeup. After a minute or so, wipe gently to remove the makeup.
Picking Your Skin
You're not a dermatologist or licensed aesthetician. You should not be picking at your pimples, ingrown hairs, or anywhere else on your face. It's one of the biggest assaults against your skin and can have permanent effects. "The more people press and manipulate blemishes, the more inflammation they create underneath," explains Dr. Shah. "The result is scars, pockmarks, and discoloration that can become permanent.”
Licking Your Lips Constantly
There's a myth out there that claims people can get addicted to lip balm. "These people just have dry skin and miss the feeling of the balm when it's gone," says Dr. Shah. Lip licking can become a bad habit. But when you moisten your lips that way, you actually wind up making things worse. The water in your saliva evaporates, leaving lips dry and cracked. "Saliva can contain bacteria and irritants, so you can end up with a rash around the lips as well," says Dr. Shah. Try a lip balm such as Burt's Bees 100% Natural Moisturizing Lip Balm, Original Beeswax with Vitamin E & Peppermint Oil.
Manish Shah, M.D., F.A.C.S. was born in Canada and raised in the Washington, D.C. area. He graduated with honors from the University of Pennsylvania, receiving a degree in biomedical engineering. He then completed his medical training at the University of Virginia, earning his Medical Doctorate. During this time, he also completed a one-year fellowship in microsurgery research at the New York University School of Medicine / Institute of Reconstructive Plastic Surgery. As a prelude to his plastic surgery training, Dr. Shah completed a rigorous five-year training program in General and Trauma Surgery at Emory University and the Medical College of Georgia. His formal training in Plastic and Reconstructive Surgery was completed at the Univ. of Tennessee College of Medicine – Chattanooga Unit. After completing his plastic surgery training, he moved to New York City when he was selected for the prestigious Aesthetic Surgery Fellowship at Manhattan Eye, Ear, and Throat Hospital. He underwent extensive, advanced training in aesthetic surgery of the face, breasts, and body at the hands of some of the most renowned cosmetic surgeons in the world. This fellowship is widely considered to be the best of its kind in the world. Dr. Shah is one of only a select few plastic surgeons in the country who has undergone formal post-graduate training in aesthetic surgery.
Dr. Shah’s specialties include revision facial aesthetic surgery, rhinoplasty (“nose reshaping”), and aesthetic surgery of the breast (breast augmentation, breast lift, breast reduction). He is, however, well-trained in all areas of aesthetic surgery.
Dr. Shah’s aim is to obtain a natural appearing transformation that complements the real you!
Dr. Shah is a Clinical Assistant Professor of Surgery at the University of Colorado Health Sciences Center. He maintains a private practice in Aesthetic Plastic Surgery in the Cherry Creek neighborhood of Denver.
Dr. Shah is a member of the American Society of Plastic Surgeons, the American Society of Aesthetic Plastic Surgery, the International Society of Aesthetic Plastic Surgery, the Rhinoplasty Society, and the European Academy of Facial Plastic Surgery.
Dr. Shah is board-certified by the American Board of Plastic Surgery.
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