This morning a client sent me a pic as they were finishing their cardio! I look into the cup holder and what do I see. Coffee. Now I myself have been guilty of caffeine while doing cardio but what is next to it...water. Good old high quality H20. You should be drinking water both during cardio and training. And here’s why:
How does drinking water during exercise impact your results
1. Hydration is a key component to how well the muscles can contract. A dehydrated muscle loses it's ability to lengthen and contract properly, which reduces power out put and can lead to a faster state of fatigue to the muscle.
2. Drinking water during exercise helps the muscles being trained stay elastic, which reduces risks of muscle strains and muscle cramps.
3. The body loses 2-3 litres of water during intense exercise over a 60 minute period. This leads to an imbalance of electrolytes. This can reduce your hearts ability to maintain normal function during training, and can lead to muscle injury and excessive fatigue/exhaustion.
4. Hydrating your body during training helps the CNS to send signals to your working muscles at a fast and efficient rate. The more efficient the CNS is, the more power the muscle can generate. Dehydration leads to a slower signal, which leads to less power out put, lowering exercise performance and a lower return of investment for your time in the gym.
5. Water helps to volumize muscle cells during exercise, which encourages the act of hypertrophy as it drives more nutrients in to the muscle cells, allowing for a greater state of anabolism.
6. Dehydration is stressful to the body, which will elevate catabolic hormones, further reducing the bodies ability to repair tissue and build muscle mass.
7. A hydrated body means a hydrated cell. When cells aren't well hydrated, the cell membrane loses it's permeability. This decreases the cells ability to release toxins and byproducts, including fatty acids... also decreasing it's ability to absorb nutrients that are essential in energy production. So dehydration during a workout will lead to less overall fat loss, and more cell damage.
8. Dehydration leads to a poor KREB cycle. The KREB cycle is the bodies process of producing energy through ATP synthesis. Without adequate ATP synthesis, many functions of your physiology are dramatically imbalanced - reducing the performance of the body, your ability to push yourself during training and how the body manages energy levels and fat loss.
Now don’t complain about the results you get from the work you're not going. Everything is important. This includes hydration. Thank me later.
Ontario government to end OHIP+ coverage for young people with private drug plans
An in-depth look at these and other subjects in the current issue of the Morneau Shepell News & Views
TORONTO, Feb. 21, 2019 /CNW/ - Morneau Shepell has released the February 2019 issue of its monthly newsletter, News & Views, in which the company looks at the following topics:
Ontario to end OHIP+ drug coverage for young people with private drug plans – On January 2, 2019, the Ontario government released a regulatory notice and draft regulation that will make OHIP+ drug coverage only available to Ontarians under the age of 25 who do not have drug coverage through a private drug benefit plan. Changes resulting from the new draft regulation will take effect in March 2019. Those under the age of 25 without private drug benefit coverage will continue to have access to approximately 4,400 drugs included in the Ontario Drug Benefit Formulary.
Canada Revenue Agency releases draft newsletter on annuity purchases from pension plans – The Registered Plans Directorate of the Canada Revenue Agency released a draft newsletter for public consultation, seeking comments on annuity purchases from pension plans by March 1, 2019. The draft newsletter provides guidance on the tax effects of the purchase of annuities by both plan administrators and individuals from registered pension plans, with a focus on purchases of annuities from defined benefit pension plans.
New provisions added to CPA Canada Handbook on financial reporting for DB pension plan sponsors– The Accounting Standards Board issued a decision summary affecting defined benefit pension plan sponsors that report under Sections 3462 (private enterprise) and 3463 (not-for-profit organizations) of the Chartered Professional Accountants of Canada Handbook. The summary provides guidance on the inclusion or exclusion of the explicit Provision for Adverse Deviations in the financial reporting of these entities.
Alberta adopts joint governance structure for large public sector pension plans – On December 11, 2018, the province of Alberta adopted Bill 27, which will transition the Local Authorities Pension Plan, the Public Service Pension Plan and the Special Forces Pension Plan to a joint governance structure. This means that new sponsor boards and corporations will be responsible for the plan design and administration, and the Alberta government will no longer act as the plan sponsor and administrator. The plans will continue to be under the jurisdiction of the Employment Pension Plan Act and the Alberta Superintendent of Pensions.
Tracking the funded status of pension plans as at January 31, 2019 – Morneau Shepell describes the funded status of pension plans at end of 2018 based on three typical investment portfolios. A graph shows the changes in the financial position of a typical defined benefit plan since the end of 2018. A table shows the evolution of the solvency ratio over January 2019 for the three typical investment portfolios.
The impact of pension expense under international accounting as at January 31, 2019– Morneau Shepell has shown the evolution of the pension expense over January 2019 for a typical defined benefit pension plan. Since the beginning of the year, the pension expense has increased by 5 per cent (for a contributory plan) due to the decrease in the discount rates, despite the good returns on assets (relative to the discount rate).
About Morneau Shepell Morneau Shepell is the only human resources consulting and technology company that takes an integrated approach to employee well-being, health, benefits and retirement needs. The Company is the largest administrator of retirement and benefits plans and the largest provider of integrated absence management solutions in Canada. LifeWorks by Morneau Shepell is a total well-being solution that combines employee assistance, wellness, recognition and incentive programs. As a leader in strategic HR consulting and innovative pension design, the Company also helps clients solve complex workforce problems and provides integrated productivity, health and retirement solutions. Established in 1966, Morneau Shepell serves approximately 24,000 clients, ranging from small businesses to some of the largest corporations and associations. With more than 4,500 employees in offices worldwide, Morneau Shepell provides services to organizations around the globe. Morneau Shepell is a publicly-traded company on the Toronto Stock Exchange (TSX: MSI). For more information, visit morneaushepell.com.
SOURCE Morneau Shepell Inc.
Night Cycling: 4 Safety Tips for Nocturnal Riders
If you enjoy cycling at night, there are some additional safety precautions that you should take to keep yourself out of harm’s way. The limited lighting at night can present extra challenges, and preparing to face these potential obstacles in advance can ensure a safer, more fulfilling ride. These four safety tips should be followed if you’re a nocturnal bike rider.
Use Reflective Gear Reflective gear will be especially important to have if you plan to ride on roads with vehicular traffic. Reflectors that are attached to the backs and fronts of bikes or tires can reflect the light of vehicle headlights and provide greater visibility for drivers. Attaching mirrors to your bicycle is also a good way to reflect light and make yourself easier to see in the dark. There are even certain types of clothing that are made with reflectors in their designs.
Ride in a Pair or Group Going for a night ride with another person or a group of people can ensure greater safety. If you end up getting hurt or encountering other dangers during your ride, you’ll have someone by your side who can offer help and alert paramedics or police, if necessary. If you’re looking for a biking buddy or group to ride with, you can search online for nighttime cycling events and meet-up groups in your area that are known to attract avid nocturnal cyclists.
Stick to Lighted Pathways You can generally find plenty of light at night on most city streets, but there are also paths for cyclists and pedestrians that stay lit well into the night. Cycling in areas with sufficient lighting can help you see the path ahead of you clearer as well as obstacles that may pose safety hazards. If you plan to cycle in an area with poor lighting, you should consider getting a headlight that attaches to the front of your bike or helmet.
Prepare for Colder Temperatures You should expect temperatures to drop at night after the sun sets, so it’s best to prepare yourself to deal with colder conditions. Custom cycling kits often work well in locking in body heat, and you should choose an option that covers the legs and arms completely if you’re cycling at night in the fall or winter. Lightweight winter cycling jackets can also protect you from the cold.
Going for a bike ride at night can still be a fun adventure if you take the time to think of ways to stay safe. By staying smart and steering clear of danger, you’ll have a greater chance of returning from your ride unharmed
Millennials commonly referred to as “generation stress” would benefit most from a steady workout routine. Yet, according to a survey conducted by the American College of Sports Medicine in 2019, 50% claim to be too busy to exercise and 35% admit to a lack of motivation.
Of the ones who do try to work out, they don’t want to be tied to expensive memberships at massive gyms. They prefer a smaller studio experience and at-home workouts leading to the growing popularity of online portals and fitness apps.
To serve up some tips specifically for millennials looking to shred up, is Vince Sant male model, Certified Fitness Trainer, Millennial Fitness Entrepreneur and Co-Founder of the V Shred online fitness portal currently “blowing up” online.
With over 600k followers on Instagram and over 800k You Tube Subscribers, Vince is a legit fitness influencer committed to offering fellow millennials fast, efficient, workouts that they can stick with that deliver visible results.
1. Do a quick HIIT
High-Intensity Interval Training(HIIT) is all over social media featuring workouts that combine short bursts of intense moves done for a shorter amount of time, followed by a short rest. These bursts get the heart pounding fast and can boost cardio-respiratory health in less time.
When you do 8 burpees in 20 seconds, knee raises for 20 seconds, then a 20 second rest. Then you do jumping jacks for 20 seconds, push-ups for 20 seconds, rest for 20 seconds, and then repeat the circuit for 10 minutes, you will see how fast it goes and how your breathing becomes heavier as your cardiovascular system is being challenged.
Vince Sant explains that “Millennials want to see fast results. We are used to immediate gratification so when you feel your body firming up and notice clothes fitting differently within a few days, you’ll be more likely to stick with it.”
2. Create an at-home mini gym that won’t break the bank.
According to Vince, whose V Shred fitness program can be done in the gym or at home, you can get away with zero equipment but if you want to take it up a notch, there are a few must-haves.. 2 dumbbells (5, 10 and 20 pounds, for beginners), resistance bands and a work out mat. “You don’t need to get too fancy with contraptions and complicated machines shown on TV. You can get a lot accomplished with these basic things that aren’t expensive at all,” says Vince.
3. No Equipment No Problem!
Check out this popular YouTube video of Vince demonstrating at-home moves using your own body resistance that can be done in under 5 minutes.
4. Create time by being body efficient.
HIIT exercises can be done within 5 minutes right in your home so time isn’t really an issue. You want to think in terms of seconds. Each move done for 25 seconds, adds up to a fast chunk of minutes. You become much more efficient and body confident as you see what you can accomplish within 90 seconds. “Imagine if all you did to get started the first week was a 20-second plank, followed by 5 push-ups, then a 30-second plank, then 30 seconds of jump squats daily before your shower. That’s less than 2 minutes and you can always increase each week,” encourages Vince.
5. Pay attention to your breathing.
Muscles need oxygen to operate at full capacity. You really want to inhale during the easier part of the move then exhale when more strength is required. “In the case of squats, you would inhale on the way down, exhale on the way up. It’s amazing how many people aren’t breathing correctly, then feel tired or even dizzy when working out. Don’t be afraid to breathe deeply. Your body needs the oxygen and the more it needs, the more work you’re getting done,” says Vince.
6. Bash through boredom by with fun, fast supersets.
Supersets call for doing multiple exercises back-to-back. “This not only helps the workout go by quicker, but it also bumps up the number of calories burned.
When doing full-body workouts, to maintain a high intensity and get the most out of pairing exercises back-to-back, alternate between upper and lower body movements. That way, one muscle group is always recovering while the other is working.
An example of a superset is 10 squat jumps followed by 20 seconds of tricep dips, 20 seconds of mountain climbers, then 15 bicep curls. You can do 4 reps of these supersets and feel that burn within 5 minutes.
7. None of it matters without the diet.
A lot of millennials use food as their motivation thinking they can eat whatever they want if they just work out. While it’s true that millennials have younger and faster metabolisms, they are also part of a generation exposed to high fructose corn syrup and supersized everything. “Eating well, along with daily workouts are what maintains your results, and you want to plan 10 years out. If you want to look and feel amazing well into your 40’s, then what you do at 25 and 30 will establish the lifestyle necessary for a long-term gain,” Vince says. He humorously adds, “Fitness is 20% exercise and 80% nutrition, you can’t out-run your fork.”
About V Shred:
V Shred is the fastest growing fitness and nutrition brand in the world offering online training programs designed to put the fun back into fitness and nutrition. V Shred provides a results-driven enduring lifestyle change instead of a frustrating battle that is easy to give up on. With a support network comprised of trusted accredited advisors and virtual personal trainers, people meet their fitness, nutrition, and goals.
The company, co-founded in 2015 by Nick Daniel, Roger Crandall, Kevin Pearn, and Vince Sant, sought out to create a healthy fitness movement specifically designed to deliver profound changes in your body with the minimal amount of workout time. V Shred has created some of the world's most popular fitness and nutrition programs such as Fat Loss Extreme for men and women, Toned in 90 Days for women and Ripped in 90 Days for men.
The diet that accompanies the workouts in these comprehensive fitness programs, offers plenty of healthy food options and recipes. V Shred’s supportive coaches encourage “portion empowerment” which inspires people to eat and enjoy food knowing it’s the fuel they need to achieve the results they seek.
V Shred is based in Las Vegas, Nevada. For more information visit http://www.vshred.com
ImmunoPrecise Antibodies Receives Subcontract to Produce Rabbit Monoclonal Antibodies
VICTORIA, Feb. 21, 2019 /CNW/ - IMMUNOPRECISE ANTIBODIES LTD. (the "Company" or "IPA") (TSX VENTURE: IPA) (OTC PINK: IPATF) has received a five-year Indefinite Delivery/Indefinite Quantity (ID/IQ) subcontract from Leidos Biomedical Research, Inc., which currently operates the Frederick National Laboratory for Cancer Research for the National Cancer Institute (NCI). Under the subcontract, IPA will discover and produce rabbit monoclonal antibodies using its proprietary B-Cell Select platform.
The rabbit monoclonal antibodies discovered and produced under this subcontract will be used in the key applications of immunohistochemistry and immuno-Multiple Reaction Monitoring (immuno-MRM). The antibodies will be generated for NCI's Antibody Characterization Program. Immuno-MRM is a leading-edge targeted mass spectrometry technique that relies on antibodies to enrich peptides from complex biological samples that are then quantified by mass spectrometry. Rabbit monoclonal antibodies are highly sought after for this purpose because they exhibit high specificity and bind their target with high affinity. Immuno-MRM is being used to discover novel biomarkers and develop a new generation of clinical diagnostic tests that could lead to improved cancer detection, diagnosis, and treatment.
IPA's B-Cell Select platform enables rabbit monoclonal antibody discovery directly from B-cells through recombinant DNA cloning and expression of antibody gene sequences. This process allows for large panels of antibodies to be screened for functionality via multiple methods to pick the most relevant leads for the final application and can be applied to discover antibodies from several species for diagnostics and therapeutics.
"We are very pleased to work with Leidos Biomedical to support the world-class cancer research funded by NCI and NIH globally. We look forward to applying IPA's experience and expertise in developing rabbit monoclonal antibodies to the challenging projects being advanced through Leidos" said Deanna Dryhurst, CSO of IPA.
About Frederick National Laboratory for Cancer Research
The Frederick National Laboratory for Cancer Researchis dedicated to improving human health through discovery and innovation in the biomedical sciences, focusing on cancer, AIDS, and rapid response to emerging infectious diseases. Frederick National Laboratory is operated by Leidos Biomedical Research, Inc. for the National Cancer Institute.
About ImmunoPrecise Antibodies Ltd.
ImmunoPrecise is a full-service, therapeutic antibody discovery company focused on the next generation of antibody discovery, to deliver the most therapeutically-relevant antibodies, in a shorter period of time, with the highest probability of succeeding to clinical trials.
ImmunoPrecise operates from state-of-the-art laboratory facilities located at the Vancouver Island Technology Park in Victoria, British Columbia, in collaboration with its wholly-owned subsidiary operations at U-Protein Express B.V., in the Life Science Incubator, Utrecht, and ModiQuest Research, Oss, both in the Netherlands. The Company operates globally to offer antibody services from target analysis to pre-clinical studies.
The services offered to clients include antibody discovery against a broad spectrum of antigens, including challenging targets. Amongst these services, the Company offers hybridoma production, B-cell services, and a variety of phage display platforms. The Company also provides a broad range of supporting services including immunologically-based assays, recombinant protein manufacturing, humanization, optimization, stable cell line development, and advanced solutions to challenges faced by clients in antibody-related research and development. The antibodies produced by ImmunoPrecise target a wide variety of therapeutic, diagnostic and research applications.
Forward Looking Information
This news release contains statements that, to the extent they are not recitations of historical fact, may constitute "forward-looking statements" within the meaning of applicable Canadian securities laws. The Company uses words such as "may", "would", "could", "will", "likely", "expect", "believe", "intend" and similar expressions to identify forward-looking statements. Any such forward-looking statements are based on assumptions and analyses made by ImmunoPrecisein light of its experience and its perception of historical trends, current conditions and expected future developments. However, whether actual results and developments will conform to ImmunoPrecise's expectations and predictions is subject to any number of risks, assumptions and uncertainties. Many factors could cause ImmunoPrecise's actual results to differ materially from those expressed or implied by the forward-looking statements contained in this news release. Such factors include, among other things, actual revenues and earnings for IPA being lower than anticipated, and those risks and uncertainties described in ImmunoPrecise's annual management discussion and analysis for the fiscal year ended April 30, 2017 which can be accessed at www.sedar.com. The "forward-looking statements" contained herein speak only as of the date of this press release and, unless required by applicable law, ImmunoPrecise undertakes no obligation to publicly update or revise such information, whether as a result of new information, future events or otherwise.
Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
SOURCE ImmunoPrecise Antibodies Ltd.
For further information:
ImmunoPrecise Antibodies Ltd., Jennifer Bath, CEO and President, 3204-4464 Markham Street, Victoria, BC V8Z 7X8, www.immunoprecise.com; For investor relations please contact: Frederick Chabot, Phone: 1-438-863-7071, Email: frederick@contactfinancial.com, Contact Financial Corp., 1450 – 701 West Georgia St., Vancouver, BC V7Y 1G5
Hard Work Pays Off as Single Mom Moves to Finals in Mompreneur Awards
CALGARY, Feb. 20, 2019 /CNW/ - Torill Myre, local Calgary mom and founder of Torill's Table has been named as a finalist for the 2019 Mompreneur Award. The single mom made the final top 30 of 1250 women who were shortlisted for the honour, due to her dedication to her business and success of her traditional Norwegian waffle mix.
The Mompreneur Award finalists are a collective of powerful women in business that have a strong dedication to their craft and passion for both family and business - which have set them apart from other entrepreneurs in Canada. Each finalist submitted an essay describing the innovation of their product, how they try to inspire others and more.
Torill's Table was born out of Myre's desire to sit down with her kids and eat something as convenient and filling as it was nutritious. "Sitting down at the table, even if it was for only five minutes, was and continues to be so important for our family," says Myre. That's when she created a nourishing waffle mix that was easy to prepare and tasted just like home. "All of a sudden, moms were asking me for bags of my mix," says Torill. "I grew up in Norway, so it was a family ritual to eat vafler every week. I wanted to bring that little piece of home to Canada."
What sounds like a smooth success story couldn't be further from her truth. "Running a business and parenting has been a juggling act," she says. Myre credits part of her success to her sons that are now ages 22, 21 and 19, who jumped right into the business and helped with warehouse tasks and selling at demos and markets. "We couldn't have done it unless we stuck together," she says proudly.
Torill graduated from Arlene Dickinson's accelerator program, District Ventures, in June of 2018 and received an investment from the business mogul to help expand her business. She was chosen for the program because of her business acumen, innovation of product and most importantly, the passion she has for supporting her family.
Stay tuned to see if this impressive entrepreneur will win this year's award at the 2019 National Mompreneur Conference on March 1st in Toronto.
Founder of Torill's Table, Torill Myre, created a waffle mix that's filled with high-quality ingredients like almonds, flax seed and oatmeal that was inspired by her mother's traditional Norwegian vafler recipe. The heart of the recipe brings loved ones together around the table to enjoy a healthy meal together.
SOURCE Torill's Table
Adaptiiv Signs Leading Canadian Cancer Centre as a Collaboration Partner
HALIFAX, Feb. 21, 2019 /CNW/ - Adaptiiv Medical Technologies Inc. (Adaptiiv) is pleased to announce that the Centre Hospitalier de l'Université de Montréal (CHUM) has become its latest Collaboration Partner. The two organizations have agreed to work together to design, develop, and validate a new solution for surface and intracavitary brachytherapy within Adaptiiv's 3DBolus Software.
The Centre Hospitalier de l'Universite de Montreal is an innovative hospital devoted to serving patients. It provides the highest quality specialized and ultraspecialized care to patients and the general public all over Quebec. Through its unique expertise and innovations, its aim is to improve the health of the adult and aging population. As the Université de Montréal hospital, CHUM is dedicated to care, research, teaching, health promotion, and the assessment of technology and health intervention methods in order to continually improve the quality of care and the health of the population. Since the fall of 2017, patients and their families have been able to enjoy a renewed hospital experience at CHUM's new facilities.
"We are excited to be a part of this groundbreaking technology," says François DeBlois, Physics Department Head, Radiation Oncology at CHUM. DeBlois is thrilled about the collaboration opportunity. "Adaptiiv is the first company to offer a platform that fully integrates into the existing treatment workflow and their team has demonstrated the ability to rapidly develop and validate new ideas that can be used in treatment today. The opportunity to work in consultation with Adaptiiv to develop and showcase new brachytherapy applications can lead to tremendous breakthroughs in radiation therapy," says DeBlois.
Adaptiiv's 3DBolus Software provides practitioners with a turnkey software solution that enables 3D printing of patient-specific devices for use in radiation therapy. Devices created using Adaptiiv's software conform to the patient anatomy to improve dose delivery and the patient experience. Patients are more comfortable throughout the treatment period and because the software fully integrates with a cancer centre's treatment planning system, set-up and production times are drastically reduced.
"We are very pleased to make this announcement," says Adaptiiv CEO, Peter Hickey. "By working with François and his team at CHUM, Adaptiiv continues to make significant strides in the battle against cancer by introducing our breakthrough technology into real world applications."
Adaptiiv is the first company in the world to receive US FDA 510(k) clearance to market its 3D printing software for use in radiation oncology. The company's software is used in the United States, Canada, Australia, Israel, Ireland, Hong Kong, and England.
About Adaptiiv Adaptiiv Medical Technologies Inc. is the definitive software platform to design 3D printed medical devices for use in radiation oncology. Headquartered in Halifax, Nova Scotia, Canada, Adaptiiv is shaping the future of patient-specific healthcare through innovation and collaboration with leading cancer centers throughout the world. Adaptiiv has US FDA 510(k) clearance, is ISO 13485 certified, and has received a CE Mark.
The CAR of the Future: Speeding Past Cancer By Joshua Mansour, MD
Have you heard about the futuristic ‘CAR’ that might soon be speeding past cancer?
No, this is not a new automotive car being released this spring, but instead is something even more exciting. This type of CAR is a cancer therapy that is making headlines and is now on the road to being one of the treatments of the future.
In a throwback to Henry Ford’s Model T, this medical innovation is called CAR T-cell therapy. The CAR stands for Chimeric Antigen Receptor. This type of cellular immunotherapy involves physicians extracting a particular type of white blood cell from the patient’s blood (T-cells) and then attaching them to one of these artificial receptors. Once these cells are infused back into the patient they begin to multiply, and with guidance from the receptor, recognize cancer cells that contain their same antigen.
This is a cancer therapy that was discovered in 1989, but has not yet been put into high gear until recently. It is already changing how patients with blood cancers that have not been responsive to previous therapy are being treated. Although the technology has been described almost three decades ago, clinical implementation has not occurred until recently. Even though CAR T-cell therapy is not well known to the general public, it has been speeding along the medical highway, with no rest stop in sight.
This rapid pace is of great value because hematological malignancies (blood cancers) are the fourth most common cancer in the United States. Non-Hodgkins Lymphoma is the most common of these in the United States and outcomes in aggressive and refractory subtypes are poor. Of this disease, the most common subtype is Diffuse Large B-Cell Lymphoma in which only small percentage of patients with relapsed disease or disease that was refractory to initial therapy is then cured with a stem cell transplant. Although this treatment has been approved for patients under the age of twenty-five with Acute Lymphoblastic Leukemia, until recently this type of therapy had been restricted to smaller clinical trials for other very advanced and aggressive diseases.
However, the remarkable rate of responses from these trials caught the eyes of researchers and physicians around the world. These results have shown that patients who had failed conventional therapy were not only seeing their disease stabilize, but also saw a significant response. Recent trials have shown ongoing complete remission with duration ranging from 18-24 plus months. In early trials, there were even persisting CAR T-cells observed in great than 70% of patients remaining in response at 1 year. Durable responses continued to remain in patients with and without detectable persisting CAR T-cells. Although these responses can deepen and improve over time, it has also been seen in instances that the ongoing response of these cells can decrease when a higher amount of tumor burden is present.
So, is this exciting CAR of the future right for every patient? No. It depends on the individual, their disease, and several other factors. Plus there are still some side effects that patients should be aware of before they take this CAR for a spin. One of them is a “cytokine storm” or cytokine release syndrome (CRS) that about 70-90% of patients may experience. Think of it as the radiator breaking down, leading to overheating of your engine with severe flu-like symptoms of fever and body aches. This occurs secondarily to the multiplying activity of the T-cells, leading to a dynamic immune response.
Another side effect, known as “CRES” (CAR T-cell Related Encephalopathy Syndrome), can begin a few days after infusion of the cells where patients become confused and disoriented. Think of it as a breakdown in the transmission. You are unable to mentally shift gears and form complex sentences and thoughts that you were able to once before. Just like when you take your automobile to a busy shop, it takes a few days for things to be back to normal. These adverse effects are reversible with the right mechanic and a skilled tune-up.
Isometric strength training exercises are one of the biggest fitness trends right now. And it’s easy to see why - they don’t require weights, intensive cardio, or even a gym. And with Activ5, the new smart isometric device designed to monitor muscle development, guide and even entertain users with five-minute fully body workouts, isometrics have become even easier.
The Best Exercises for Knee Pain: Isometrics as Knee Injury Exercises
You might be surprised to learn that the ideal exercises for those who suffer from knee pain involve isometrics. Because while rest is an essential part of recovery after a knee injury, restoring strength is a vital part of preventing future injuries to the joint. The most common causes of knee injuries is damage to the ACL, also known as the anterior cruciate ligament. And the best way to protect the ACL is by strengthening the muscles around the knee. Essentially, the stronger these muscles are, the better your knees will be at absorbing shock--one of the typical causes of ACL injuries.
After a knee injury, most physicians and physical therapists recommend gentle exercise to strengthen the surrounding muscles. That means avoiding weight-bearing exercises or moves that compress the knee. Fortunately, isometric exercises are extremely low-impact and great for rapidly strengthening the muscles. Studies have shown that isometric exercises are extremely effective at targeting the muscles and tendons surrounding the knee.
The 5 Biggest Disruptors Wreaking Havoc On Your Hormones
As 2019 dawns, some people are taking a “new year-new you” approach. They’re determined to make self-improvements that provide a fresh, positive outlook and strong sense of well-being.
But sometimes health factors undermine those good intentions, such as depression and its link to hormone imbalances. There are myriad ways both men and women suffer adverse effects to their hormones, says Don Colbert, M.D., and many of them are avoidable.
“We are exposed to thousands of toxic chemicals on a regular basis in the air, water and food,” says Colbert (https://drcolbert.com), author of Dr. Colbert's Hormone Health Zone. “Some of them are hormone disruptors because they disturb your endocrine system, wreaking havoc and creating hormonal imbalances.
“Not only are the effects of all these disruptors depressing to think about; they actually cause depression, along with countless other ailments such as type 2 diabetes, high blood pressure, heart disease, obesity and more. But the basic principle is this: decreasing the number of disruptions will improve your health.”
Dr. Colbert breaks down the top hormone disruptors affecting men and women along with ways to minimize the disruption or stop it:
Lifestyle choices. “Whether it’s weight gain and a lack of exercise, anger and unforgiveness, drinking too much alcohol or some other thing that can be controlled, your hormone levels drop and you begin a slow slide to poorer health,” Dr. Colbert says. “Make better choices, and that dramatically decreases the chances of having any hormone deficiency symptoms.”
Medications. Medications affect the body’s cells, and sometimes side effects manifest in major problems. For example, Dr. Colbert cites Mayo Clinic research showing a prescription statin drug that lowered cholesterol could result in liver damage, memory loss or type 2 diabetes. “I estimate that 55 percent of the entire US population is taking pills that directly and negatively affect hormone levels,” Dr. Colbert says. “Get off these harmful medications you hate.”
Things you touch. Chemicals entering the body through the skin can cause long-term damage. Dr. Colbert notes phthalates, disruptors found in household cleaners, cosmetics, toys and numerous other products. “Phthalates negatively affect both men’s and women’s ability to use the testosterone that is in our bodies,” Dr. Colbert says. “Another is BPA (bisphenol A), found on the inside of metal-canned foods and plastic food-storing containers. Specifically, BPA has been found to cause or contribute to cancer, fertility problems, developmental issues and heart disease. I recommend buying glass jars of food and storing in ceramic containers.”
Diet deficiencies. “The standard American diet is usually low in key nutrients that support a healthy thyroid,” Dr. Colbert says. “Many patients with hormone imbalances have low iodine. The best solution is eat more vegetables, ideally raw or steamed.”
Aging. Dr. Colbert says estrogen levels for women begin to decline around the age of 50; for men, testosterone levels can drop low around age 45-50. “Aging is a natural combatant as a hormone disruptor,” he says, “but we can slow the acceleration of the effects of aging by optimizing our hormones. Healthy habits can make a huge difference.”
“Symptoms of serious problems indicated by hormonal imbalance can be reversed by those who focus on health in their diet, lifestyle and living environment,” Dr. Colbert says. “Then they can enable all of their systems to function optimally.”
About Don Colbert, M.D.
Don Colbert, M.D. (https://drcolbert.com), is the author of Dr. Colbert's Hormone Health Zone. He has been a board-certified family practice doctor for more than 25 years and has offices in Orlando, Fla., and Dallas. The author of over 40 books, he wrote two New York Times best-sellers - The Seven Pillars of Health and Dr. Colbert’s “I Can Do This” Diet - has sold more than 10 million books and treated 50,000-plus patients. Dr. Colbert is a frequent show guest of Christian leaders Joyce Meyer, John Hagee, and Kenneth Copeland and has been featured on The Dr. Oz Show, Fox News, ABC World News Tonight, and in periodicals such as Newsweek and Reader’s Digest.
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