ProMIS Neurosciences Identifies Novel Targets on Tau Protein Involved in the Development of Alzheimer's Disease and Other Dementias

 

ProMIS' proprietary discovery platform generates additional potential opportunities for pharma partnering

TORONTO and CAMBRIDGE, MA, Oct. 31, 2018 /CNW/ - ProMIS Neurosciences, Inc. (TSX: PMN) (OTCQB: ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, today announced the identification of novel targets on misfolded, pathological forms of tau. The development of antibody therapeutics that selectively block these toxic forms of tau constitutes an exciting approach to treating Alzheimer's and other neurodegenerative diseases.

"Using our unique discovery platform, we were able to identify several novel targets displayed on misfolded forms of tau. We now look forward to generating antibody candidates that selectively block these toxic forms of tau." stated Dr. Neil Cashman, ProMIS Chief Scientific Officer. "In addition to PMN310, our lead therapeutic candidate that selectively targets the toxic oligomers of amyloid beta, a root cause of Alzheimer's disease, the development of antibodies selective for toxic forms of tau affords ProMIS a 'one-two punch' in our armamentarium to fight Alzheimer's disease."

The tau protein plays a key role in stabilizing the microtubules in central nervous system neurons. The development of misfolded forms of tau leads to toxicity and abnormal neuronal function seen in Alzheimer's disease, frontotemporal dementia and other tauopathies such as repetitive head injury (chronic traumatic encephalopathy, or CTE).

Commenting on these results, Dr. Elliot Goldstein, ProMIS President and CEO stated: "ProMIS' proprietary discovery platform continues to show outstanding ability and efficiency to predict novel therapeutic targets and generate highly selective therapeutic antibodies for multiple neurodegenerative diseases. Having previously announced encouraging antibody candidates for ALS (targeting TDP43) and Parkinson's disease (targeting alpha-synuclein) and now novel targets on tau protein, we have additional exciting opportunities for high value pharma partnering across a broad spectrum of neurodegenerative diseases in 2019."

About ProMIS Neurosciences
ProMIS Neurosciences, Inc. is a development stage biotechnology company focused on discovering and developing antibody therapeutics selectively targeting toxic oligomers implicated in the development and progression of neurodegenerative diseases, in particular Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). The Company's proprietary target discovery engine is based on the use of two complementary techniques. The Company applies its thermodynamic, computational discovery platform -ProMIS™ and Collective Coordinates - to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this unique precision medicine approach, the Company is developing novel antibody therapeutics for AD, ALS and PD.  ProMIS is headquartered in Toronto, Ontario, with offices in Cambridge, Massachusetts. ProMIS is listed on the Toronto Stock Exchange under the symbol PMN, and on the OTCQB Venture Market under the symbol ARFXF.

For further information about ProMIS Neurosciences, please consult the Company's website at: www.promisneurosciences.com

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The TSX has not reviewed and does not accept responsibility for the adequacy or accuracy of this release. This information release contains certain forward-looking information. Such information involves known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements to be materially different from those implied by statements herein, and therefore these statements should not be read as guarantees of future performance or results. All forward-looking statements are based on the Company's current beliefs as well as assumptions made by and information currently available to it as well as other factors. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this press release. Due to risks and uncertainties, including the risks and uncertainties identified by the Company in its public securities filings, actual events may differ materially from current expectations. The Company disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

SOURCE ProMIS Neurosciences Inc.

The Mummy Tuck: Procedure Aims to Restore Postpartum Body Confidence

 

TORONTO, Oct. 31, 2018 /CNW/ - Nearly two years ago, Kelly, then 46, realized diet and exercise alone was not going to get her back to her pre-baby body. The mother of two children, currently aged eight and eleven, hadn't worn a pair of jeans in nearly ten years and decided to explore her options. Now, the 48-year-old happily wears jeans, and even a bikini, with confidence. The reason – the Mummy Tuck.

Post-pregnancy, there are many new-moms who can bounce back to their pre-baby bodies through exercise and eating healthy. However, some women can't get rid of the belly pooch, no matter how many SoulCycle or Pilates classes they push through. Anna, a 46-year-old mother of two children aged seven and five, was hesitant about the Mummy Tuck at first, but after doing some Internet research she knew it was the right path forward. "I initially thought 'no way', but after having the kids I was never the same." Anna says, "I lost all of this weight and the extra skin bothered me so much. I started looking online at before and afters and thought 'that's pretty amazing'."

Both Kelly and Anna came across Power Plastic Surgery, an all-female private practice, through some Google searches. They both knew they wanted a female doctor, as Kelly says, "because who knows a woman's body better than a woman." Dr. Stephanie Power works with her Mummy Tuck patients to restore their body confidence post-pregnancy.

The tummy isn't the only area that adjusts during pregnancy. A Mommy Makeover, which addresses both the abdomen and breasts, are becoming increasingly popular. "Mommy makeover -- cosmetic breast surgery and tummy tuck -- is one of the most common procedures in my practice," says Dr. Power. "While pregnancy may be possible after a tummy tuck, it is recommended to wait until finished having children before undergoing this surgery.  The results of a tummy tuck would be compromised otherwise.  I make similar recommendations to women considering cosmetic breast surgery if planning a pregnancy in the near future."

"I wasn't overweight, I just had this excess of skin," says Kelly. "There was nothing I could do to get rid of it. I felt guilty going out there and spending money on this instead of my family or taking a vacation. Dr. Power's reassurance that there's absolutely nothing else I could do to get rid of the skin, and that it will make a huge difference really played a huge role in adjusting my thinking – that I wasn't dieting enough or working out enough. I just couldn't change it and it was nice to have that reassurance."

Referred to in the medical field as an Abdominoplasty, the procedure improves abdominal contour, corrects excess abdominal skin and tissue and repairs the rectus diastasis (those "six pack" muscles). Basically, it helps to vanish love handles, muffin tops and create that coveted hourglass shape.

Anna was initially worried that a visit to the plastic surgeon's office would be a frustrating experience, with the doctor pointing out all her flaws. "Dr. Power had a very nice approach. After watching TV shows you think you are going to go in and the plastic surgeon is going to draw on you and tell you everything that's wrong. She didn't do that at all. Often doctors have an arrogance and she was like to talking to a regular person," Anna explains.

Post surgery, the patient remains overnight until the following morning for observation and pain control. Anna had her procedure back in June and notes the recovery is similar to when she had a C-Section. She didn't experience any complications.

When asked if they would do the procedure again should they have to, both didn't hesitate in responding, "yes". Anna adds, "It couldn't have been any better than it was, mostly because of Dr. Power, she knows her stuff. I felt really confident with her and knew things weren't going to go sideways."

The Mummy Tuck is performed under general anesthetic. Patients are generally able to return to work within 1 – 2 weeks but should refrain from heavy lifting for 4 – 6 weeks. For more information, or to request an interview with Dr. Power, please contact Gillian DiCesare, gd@overcat.com.

ABOUT POWER PLASTIC SURGERY

Opened in 2013 by Dr. Stephanie Power, Power Plastic Surgery is an all-female practice located in Yorkville, Toronto. Performing both cosmetic and reconstructive procedures, the practice provides patients with personalized care in state of the art operating rooms. Dr. Power personally performs each consultation and surgery and maintains open communication with each patient following their procedures to address any questions they may have. For more information about Power Plastic Surgery, please visit http://www.powerplasticsurgery.com/.

SOURCE Power Plastic Surgery

BlockStrain: Taking The Marijuana Industry Out Of The Shadows And Safely Into The Future

New York, NY, October 30, 2018 — The world has seen many changes developing around the use of marijuana over the past decade. With the majority of states in the US now legalizing some aspect of cannabis, Canada is about to become the first G7 country to fully legalize the drug for medical and recreational purposes. While there is a great deal of interest from business giants, such as, Coca Cola, Constellation Brands and even Walmart, to stake their claim in this exciting and evolving industry, states such as Colorado and California continue to run into the same problem—how to bring integrity and quality assurance to an industry born in the shadows.

While the Canadian government has regulations on legal marijuana, these regulations are not stopping tainted products getting into the marketplace. There is currently no system in place to monitor and track the product to ensure it is safe. That is, until now.

One innovative technology company based in Vancouver, BC has tackled this issue by combining years of sophisticated enterprise technology with the innovation of blockchain. BlockStrain Technology Corporation has developed the first, fully integrated blockchain platform that brings product testing, visibility and integrity to the cannabis industry to bring actionable and real-time quality assurance. BlockStrain is here to use big data to make assurances that customers are protected and to assure the quality and safety of the product.

"Fortunately, BlockStrain accomplishes this by combining the power of genetics with decentralized ledger technology for DNA-based product integrity, verification and tracking. Now, for the first time, consumers can actually know that what they are purchasing is safe, clean and from a legal source. Additionally, although this software is being designed to support the evolving cannabis industry, it could also work to ensure that the organic food industry is also safe and fair-trade. We believe this is a pretty good marriage between science and technology," says Robert Galarza, CEO of BlockStrain.

Mr. Galarza recently announced the addition of Derek Pedro to BlockStrain's Advisory Board. Mr. Pedro was a co-founder and Master Grower at Maricann Group Inc., an early Licensed Producer under the Access to Cannabis for Medical Purposes Regulations (ACMPR), and is currently the Design, Cultivation and Production Partner at WeedMD Inc., where he designed and supervised construction of that company's production facility in Ontario. "Having Pedro's deep expertise on this board is critical as the company develops its software for use in the evolving legal cannabis industry in Canada,” says Galarza, adding, "He is both a pioneer and a legend in this industry and his knowledge of strain genetics and production systems is incredibly beneficial to BlockStrain as the company builds and adapts its platform for Licensed Producers and other industry stakeholders in Canada.”

Profound Answers May Lie Beyond Human Awareness

Los Angeles, CA, October 30, 2018 — In his deeply insightful writings, Dr. Pieter Noomen shares what he discovered through transcendent experiences during which he fully connected with the source of all existence — something he asserts can be achieved by every human being who is willing to open his or her mind to the information from the universe.

Over the course of many years, Noomen was granted transformative "visits” into another human dimension — on the spirit level — and he freely shares the universal and eternal facts of life that were communicated to him on his website, www.wordsforall.org.

As he explains on his website, "I can only say that the information came from a presence on my innermost spiritual level I was in communication with for some time. The words seem the result of my spirit merging with the spirit of life It/Her/Himself.”

Visitors to Noomen's website can read about the 12 components of life through his 12 booklets: Oneness, Love, Life, Fire, Space, Connectedness, Progression, Effect, Freedom, Joy, Differentness and Harmony. Throughout his writings, Noomen avoids using the name of any deity, such as God, and instead uses what he refers to as The Seven Names, each of which relates on a human level to the situation at hand: One Holy, Love, Truth, Proper, Healing, Manifestation and Energy.

A series of lessons on the site shares 147 thought-provoking questions and the illuminating answers that came to him during his extensive communications with the All Spirit.

Ultimately, Noomen posits that directly or indirectly, life stems from one common source and that to connect with that source is the highest level of existence we can achieve on earth.

"In death,” Noomen writes, "everyone will, without exception and in a purely personal way, find out whether or not there is another dimension of existence.” The reflections shared on Noomen's website invite readers to not wait until the end of their earthly lives for the answer.

Born in the Netherlands, Pieter Noomen completed doctoral studies in theology and pastoral psychology at the Free University of Amsterdam and was senior minister of three protestant churches. Later he worked as a psychotherapist and as a staff member of a Los Angeles metropolitan church. He was involved in mental health issues like suicide prevention and hospice. His personal spiritual path widened substantially — unexpectedly and quite sensationally —25 years ago when he was drawn to the insights of Dr. Peter D. Francuch (1934-2001), who wrote about his communications with what he called the Positive State. This led to Noomen's interest in experiencing a direct, personal connection with the One Who is Life. Noomen is retired and resides in Hollywood, California.

To read the works of Dr. Pieter Noomen, please visit www.wordsforall.org.

Two-thirds of Canadian women are unaware common leg complaint can point to a progressive health issue

 

New poll reveals almost three-quarters of women have experienced at least one symptom associated with chronic venous disease, but only half with symptoms have spoken to their doctor1 

LAVAL, QC, Oct. 30, 2018 /CNW/ - A new survey by Leger reveals as many as two-thirds of Canadian women are unaware that varicose veins can be a sign of underlying chronic venous disease,2 a progressive condition caused by poor blood circulation in the legs.3,4

A fifth of the Canadian adult population suffers from varicose veins and 60 per cent of those affected are women.5 Varicose veins often appear as prominent or bulging blue protrusions under the skin of the leg, while other less visible symptoms include a feeling of heaviness, in addition to swelling, itching and pain in the legs.6

The online survey of 1004 Canadian women aged 35-60, revealed that, despite their symptoms, almost half of women (49%) believe varicose veins to be a natural part of aging, while only one-third associated varicose veins with a medical chronic condition.7

Chronic venous disease is a progressive condition of the legs that causes vein walls and/or valves to become inflamed and stop working effectively, making it difficult for blood to return to the heart from the legs.8 Signs and symptoms range from a sensation of heavy and/or painful legs, night cramps, edema or ulcers, spider and varicose veins.9

"I frequently encounter patients who believe varicose veins are a purely cosmetic condition, and who do not understand their potential underlying cause," says Dr. Beverley Chan, Vascular surgeon at Oakville Vascular. "It's important that people recognize varicose veins are not simply a result of aging, but could be a sign of chronic venous disease, a condition that can result in disabling physical and psychological pain."

Despite revealing that only 11 per cent of women are aware of the disease, the poll showed almost three quarters of those polled (70%) have experienced at least one symptom.10 In particular, more than 80 per cent with varicose veins also report having experienced at least one other symptom, including aching legs, painful legs, night cramps, heavy legs or itchy legs.11

The survey also reported that over half of women with symptoms of chronic venous disease felt they were not serious enough to speak to their doctor about.12 When asked what would prompt a visit to the doctor's office, the majority of women (41%) answered pain.13

"All too often I see patients suffer from uncomfortable and painful symptoms associated with this condition, which can impact daily activities like taking a shower, walking or driving affecting overall quality of life," says Dr. Beverley Chan, Vascular surgeon at Oakville Vascular.

"The good news is that there are treatment options, including over-the-counter medications that address the venous inflammation and loss of venous tone, which helps relieves the signs and symptoms of mild-to-moderate chronic venous disease."

There are several options to help treat the signs of varicose veins and chronic venous disease, including over-the-counter medications, lifestyle changes and compression stockings, other treatments include vein stripping, endovenous procedures and sclerotherapy.14

About Servier Canada

Servier Canada was established in 1978 and is celebrating its 40th anniversary of operation in Canada. Servier Canada employs over 250 people and is currently present in the following markets diabetes, cardiovascular disease and oncology. For more information: www.servier.ca

About Servier

Servier is an international pharmaceutical company governed by a non-profit foundation, with its headquarters in France (Suresnes). With a strong international presence in 149 countries and a turnover of 4.152 billion euros in 2017, Servier employs 21,700 people worldwide. Entirely independent, the Group reinvests 25% of its turnover (excluding generic drugs) in research and development and uses all its profits for development. Corporate growth is driven by Servier's constant search for innovation in five areas of excellence: cardiovascular, immune-inflammatory and neuropsychiatric diseases, cancer and diabetes, as well as by its activities in high-quality generic drugs. Servier also offers eHealth solutions beyond drug development. More information: www.servier.com.

References:
_________________________
1 Leger 2018, Servier, Chronic Venous Disease Report, pp 5, 7, 8, 10, 11, 15.  (On File)
2 Leger 2018, Servier, Chronic Venous Disease Report, pp 5, 7, 8, 10, 11, 15.  (On File)
3 Bergan JJ, et al. Chronic Venous disease. N Eng J Med. 2006;355:488-498.
4 Bergan JJ, et al. Pathogenesis of primary chronic disease. J Vasc Surg. 2008;47(1):183-192.
5 Canadian Society for Vascular Surgery. Varicose Veins. Accessed September 17, 2018. Available at: https://canadianvascular.ca/Varicose-Veins
6 Canadian Society for Vascular Surgery. Varicose Veins. Accessed September 17, 2018. Available at: https://canadianvascular.ca/Varicose-Veins
7 Leger 2018, Servier, Chronic Venous Disease Report, pp 5, 7, 8, 10, 11, 15.  (On File)
8 Cleveland Clinic. Chronic Venous Insufficiency (CVI): Overview. Accessed on September 13, 2018. Available at: https://my.clevelandclinic.org/health/diseases/16872-chronic-venous-insufficiency-cvi
9 SERVIER CANADA INC. Venixxa Product Insert. Accessed September 5, 2018. Available at : https://www.servier.ca/sites/default/files/webform/Venixxa%20Product%20Insert_CVD_EN_r.pdf?ts=1510420330
10 Leger 2018, Servier, Chronic Venous Disease Report, pp 5, 7, 8, 10, 11, 15.  (On File)
11 Leger 2018, Servier, Chronic Venous Disease Report, pp 5, 7, 8, 10, 11, 15.  (On File)
12 Leger 2018, Servier, Chronic Venous Disease Report, pp 5, 7, 8, 10, 11, 15.  (On File)
13 Leger 2018, Servier, Chronic Venous Disease Report, pp 5, 7, 8, 10, 11, 15.  (On File)
14 Canadian Society for Vascular Surgery. Varicose Veins. Accessed August 22, 2018. Available at: https://canadianvascular.ca/Varicose-Veins

 

SOURCE Servier Canada

Is ADHD Connected to Maternal Cholesterol Levels?

During pregnancy, a woman’s body undergoes a massive transformation in pretty much all aspects – from physical to emotional, and sometimes even mental. One of the changes that happen in a woman’s body is the change in her cholesterol levels. The cholesterol levels increase to make steroid hormones, such as estrogen and progesterone that are crucial for carrying a healthy pregnancy to term. Typically, women’s cholesterol levels increase by 25% to 50% during pregnancy, while HDL levels rise even more.

Where Do Recent Studies Stand?

Lately, there’s been much talk about the link between ADHD (attention-deficit-hyperactivity disorder) in children and maternal cholesterol levels, with girls being less susceptible to the effect than boys. What makes this research different than the previously conducted ones, is that this one is focused on children, while prior ones mostly focused on adults’ cholesterol and brain functions. The finding that suboptimal maternal cholesterol levels may increase the risk of ADHD is almost a breakthrough in the conclusions of this type. What is more, scientists explain that this is true for low high-density lipoprotein (HDL) in particular.

What Else Makes This Finding Special?

Even though this research is still in its beginning stages and needs additional investigation, it “raises new hypotheses about ADHD gender differences and future targets to prevent the disorder.” Researchers based their testing on data from the Boston Birth Cohort. The cohort was followed from birth up to age 15 and mostly comprises of low income, urban, and minorities.  The final analyses rounded up 1479 mother-infant pairs: 1176 neurotypical children, and 303 children with ADHD.

Judging by the results, an increased risk of ADHD associated with low maternal HDL cholesterol level (≤60 mg/dL), compared to a higher maternal HDL cholesterol level.

What Role Did Gender Play?

The research included both girls and boys, hoping to establish which gender (if any) was affected more. As reported, and based on the associations with ADHD for maternal HDL cholesterol and triglycerides, it appears that boys were more affected and vulnerable to suboptimal maternal cholesterol levels. The finding is believed to have shed new light on the ADHD sex difference.

Are There Any Implications To These Findings?

Researchers explain that there might be several implications:

  • Women with a child typically maintain a higher level of HDL cholesterol
  • Popular clinical cut-off point for HDL cholesterol (>50 mg/dL) for women who are not with a child aren’t necessarily adequate for protecting against ADHD in offspring
  • A higher cut-off point is believed to be a better option when identifying the fetus at risk for future ADHD

What Were The Limitations of the Study?

As reported, there were a few limitations:

  • The study based on a single measurement of non-fasting maternal cholesterol
  • The measure was taken 24 to 72 hours after delivery suggesting that lipid levels would be more optimal when collected throughout the entire pregnancy
  • The analyses could not capture all risk factors of ADHD as it focused on the population of low-income, urban, mostly minorities only; the study observed that this target group is at a higher risk of exposure to other ADHD risk factors

Keeping your cholesterol levels in check is a must for all pregnant and non-pregnant women. Consult with your physician on taking supplements, such as Cholesterade®, you should take.

4 Reasons Why Extreme Dieting Cripples Your Fitness Routine

With obesity rates higher than ever, more people are desperately trying to lose weight by experimenting with fad diets and exotic eating plans. Although it is more sensible to follow a nutritious eating plan for life to successfully and safely lose weight, some people lose dangerous amounts of body weight, becoming more unhealthy rather than healthier. Because physical activity is often recommended to be followed hand-in-hand with a diet plan, a person's fitness routine can be hindered by losing an extreme amount of weight, especially without medical supervision. These dangerous dieting mentalities may even lead to eating disordersin the future.

Weakness
People who do not eat enough calories to sustain physical health often become weak and debilitated. Some are unable to perform daily functions needed for healthy living, and many are unable to handle their daily fitness schedule, as they lack the energy and motivation to do so, based on an inadequate calorie count or metabolic imbalance.

Fatigue
In tandem with weakness, fatigue is often a byproduct of extreme weight loss. Without enough calories to provide fuel for bodily needs, a person can feel exhausted and tired, often preferring to rest rather than exercise. If they do make it to the gym or start their daily routine, it may be cut short due to insufficient energy.

Dwindling Focus
Fast or extreme weight loss often takes a toll on the brain as well as the body. Lacking enough food-based fuel to carry oxygen to the cells and organs, including the brain, a person is unable to think clearly or sustain focus. As a result, trying to make it through a regular physical workout may be undoable. Their attention might wander, or other thoughts may draw attention away from the physical activities being attempted. The person trying to exercise may become distracted or experience foggy thinking.

Disinterest
Following a significant weight loss, some people may no longer feel a need to exercise. They assume since they weigh less and are approaching their ideal size, exercise is optional. They fail to realize that exercise is important for people of all ages and weights, keeping the body and mind in shape for a lifetime. Even the will, or desire to exercise, may dwindle if the person gets caught up in a new self-centered lifestyle that does not include physical workouts.

Weight loss should always be carried out under a doctor's supervision. Losing a huge amount of weight can negatively impact a fitness routine as shown above. Ask your doctor about the role of exercise when dieting.

 

Wilfrid Laurier University becomes first institution in Canada to have two full-size, life-like synthetic humans

 

WATERLOO, Ont. – Wilfrid Laurier University in Waterloo, Ontario is the recent recipient of two full-sized, multi-functional synthetic human models from SynDaver Labs in Tampa, Florida, making WLU the first institution in Canada to possess two full-body SynDaver Synthetic Humans.

 

The installation of the synthetic human models was completed Oct. 11 and will be utilized by undergraduate students, graduate students and high school students in the local area beginning Oct. 22.

 

The new human models will satisfy the need of improving student learning experiences by having a full-body synthetic model, allowing students to better understand the intricacies of the human body structure.

 

While the addition of the two synthetic humans supports the existing curriculum, WLU is planning on utilizing them for future course development and curriculum expansion.

 

Furthermore, the ownership of the two SynDaver surgical models will allow WLU to create an outreach program for area high schools and other post-secondary institutions to aid in their students’ learning capabilities about the human anatomy and increase awareness of programs at WLU’s Faculty of Science.

 

“Through the purchase of these synthetic humans, we can give a hands-on experience and enhance the students’ knowledge without the complications that come with setting up a traditional cadaver lab,” said Kristen McFall, Laboratory Coordinator at Wilfrid Laurier University. “We believe that the quality and detail of the SynDaver models will enhance our students’ understanding and experience.”

 

SynDaver’s synthetic humans, animals and task trainers imitate the anatomy of live patients in detail, including individual muscles, tendons, veins, arteries, nerves and organs, which are made from complex composites that emulates the properties of living tissue. The company’s synthetic tissues are comprised of water, fibers and salts. Each of these non-toxic, non-latex tissues have been validated for mechanical, physicochemical, thermal and dielectric properties against the relevant living tissue.

Currently used around the globe, SynDaver products are replacing live animals in development tests, replacing human cadavers in anatomy instruction, surgical training and mortuary science, and utilized by military medics and first responders in trauma scenarios, battlefield medical training and other life-support training situations.

For more information on Wilfrid Laurier University or their Faculty of Science programs, visit www.WLU.ca.

For more information on SynDaver or their synthetic human or animal cadavers, visit www.SynDaver.com.

 

About SynDaver
Headquartered in Tampa, Florida, SynDaver is the world’s leading manufacturer of hyper-realistic, synthetic human and animal surgical trainers. SynDaver’s synthetic bodies simulate fully-functioning live organisms and are primarily used for training in schools, hospitals and military installations. SynDaver has the world’s largest database of live-tissue properties and all SynDaver tissues are made from water, salts and fibers. The company currently has 14 patents on these materials, processes and related products. Currently, SynDaver Labs employs more than 100 people at their facilities in the U.S. and is planning additional facilities in Europe, China, Brazil and India.

 

SynDaver products have been lauded by industry experts and earned a cult following after appearances on ABC’s Shark Tank, MythBusters, Grey’s Anatomy, and the series finale of CSI. The company's models are also expected to feature prominently in multiple episodes of the upcoming MythBusters 2.0.

 

 

 

HACK YOUR WAY TO FRUGAL FITNESS WORKOUTS WITH THESE TIPS

www.vshred.com

Achieving a toned, fit body does not have to break the bank. Yoga and Pilates classes, personal trainers and gym memberships are not financially realistic for all people. For parents, going to the gym means having to worry about childcare, therefore adding another expense.  Just because you don’t have a fat wallet does not mean you can’t get buff.  The following are budget friendly at home fitness tips from Gerald Mayes, a certified fitness trainer with www.vshred.com

 

HERE ARE THE HACKS:

Use soup cans for weights.

Gerald Mayes says that “You can do any triceps or biceps exercise at home using cans of soup that you'd do at the gym with dumbbells. To properly gauge the weight, don't go by the ounces listed on the can -- that's liquid weight. Instead, weigh the cans on your scale to figure out the poundage that's best for you.”

 

Use jugs as weights.

Fill a household bucket or jug with water (or sand, rock salt, or powdered detergent) and secure the top with duct tape. Lift it up and down in front of you as you do squats.

 

Substitute paper plates for body sculpting equipment.

“The key here,” Gerald says, “is to use the plates to help your body slide on a carpet. This allows you to do body sculpting moves that would ordinarily require workout equipment. You can do the sliding lunge (put the paper plate under one foot and lunge forward). Try simulating skating to work your butt and thighs -- just attach the plates to your feet with rubber bands and slide away. Or, get down on all fours, put the plates under your hands, and use them to work your chest by sliding your arms back and forth.”

 

Substitute a countertop for a push-up bench.

In most homes, at least one countertop, either in the kitchen or the bath, is the right height for a push-up. Put both hands on the countertop, extend your legs behind you at an angle, lean down into the counter, and then push back up.

 

Substitute pantyhose for resistance bands.

“Almost any exercise you can do with a resistance band, you can do with old pantyhose or tights,” says Gerald.  For example, sitting on the floor with your legs straight, loop a pair of pantyhose around the balls of your feet and pull back with both hands as if you are using a rowing machine.

 

A fitness ball.

Sometimes called a stability ball, looks like a large beach ball. You can do many core exercises, including abdominal crunches, with a fitness ball. You can also use a fitness ball to improve your flexibility and balance.

 

Kettlebell.

A kettlebell is a round weight with the handle attached at the top. A kettlebell can be used to do strength-training exercises and to help improve grip strength. Kettlebells are available in many sizes.

 

Jump-ropes.

Skipping rope can be a great cardiovascular workout.

 

Resistance tubing.

These stretchy tubes offer weight-like resistance when you pull on them. Use the tubes to build strength in your arms and other muscles. Choose from varying degrees of resistance, depending on your fitness level.

 

Chair or step stool. Use a chair for support when doing exercises such as leg curls. A low, sturdy step stool can become exercise equipment if you use it for step training — an aerobic exercise resembling stair climbing.

Towels

Make your waist-whittling planks more effective with towels says Gerald . Take two and place them under your hands or feet, then move forward, backward and sideways.

 

Clean Sweep

This one’s easy: You can burn 80 calories every 20 minutes of sweeping. Pull out the broom and get to sweeping every corner of your house or apartment. How’s that for multitasking?

 

Laundry Twist

Gerald says,  “Sit next to a full basket of laundry and twist to grab an item from the basket. Twist to the other side to lay it on a pile. Continue until your laundry is finished.”

 

Become a member of an online fitness platform

Vshred.com guides users to the very best program for their body type and fitness goals while giving them some amazing tips they can use that day in a video and then offers them a program that's perfect for them if they don't want to do it themselves.

 

Take the V Shred Quiz Here.

 

About V Shred

V Shred is a leading brand encompassing online fitness, nutrition, personalized training products, and related services. With millions of YouTube viewers and 600,000+ inspired clients worldwide, we know people are busy, so our goal is to make fitness fun and effective in the shortest amount of time possible!

We offer a variety of guided programs and custom diet plans, including personalized fitness training from top-tier trainers, to help our customers achieve real, attainable results. We pride ourselves aligning our customers' ideal health and fitness goals with proven programs to make a positive impact on the way they look and feel.

Visit our website to learn more: http://vshred.com[1]

 

 

Gerald Mayes Trainer Bio

Gerald Mayes, a married father of 4 is a V Shred Lead Trainer, a Certified Personal Trainer through the National Strength and Conditioning Association (NSCA) and sat on the Nevada State Board. He is also a certified Health Coach through the American Council on Exercise (ACE) where he writes the certification curriculum. After being honorably discharged in 2010, Gerald gained a significant amount of weight going from 177 to 301 in a year. After hitting a low in his life, knowing his health would only spiral down further, Gerald met a trainer who helped guide him towards adopting a healthy lifestyle. After achieving his result, he knew he wanted to do the same for others. Over the next few years, he dedicated himself to learning as much as he could about health and fitness earning him an Associates in Personal Training, a bachelor’s degree in Public Health and a Master's Degree in Sports in Health Science and worked his way up to one of V Shred’s lead trainers!

 

Today Gerald’s many clients include everyone from fellow Marines and other members of the Armed Forces who often return from service in need of support when transitioning into civilian life to stay at home moms who want to get back in shape despite having a hectic schedule.

 

REKOVELLE®, the first recombinant follicle stimulating hormone derived from a human cell line, is now available for Canadian women undergoing IVF and other assisted reproductive technologies

 

REKOVELLE® helps women achieve a more predictable and targeted ovarian response

TORONTO, Oct. 29, 2018 /CNW/ - Ferring Pharmaceuticals announced that REKOVELLE® (follitropin delta injection), the first recombinant FSH for controlled ovarian stimulation derived from a human cell line, is now available in Canada for women undergoing assisted reproductive technologies such as in vitro fertilization (IVF).1 Ovarian response to stimulation varies considerably from woman to woman,2 and unexpected extreme responses have implications on efficacy and safety.3,4 REKOVELLE® is the first gonadotropin to use an evidence-based, personalized dosing algorithm based on a woman's anti-Müllerian hormone (AMH) level and body weight to achieve a predictable ovarian response.1

"One in six Canadian couples experience infertility and many couples feel anxious about the unknowns of reproductive medicine when they go through IVF for the first time," says Dr. Al Yuzpe, Reproductive Endocrinologist, Co-Founder and Co-Director of Olive Fertility Centre in Vancouver. "REKOVELLE® provides a more predictable and personalized option considering each woman's AMH and body weight. We finally have an FSH preparation that is dosed based on scientific evidence, removing the subjective decision of choosing the appropriate dosage of FSH for each woman."

REKOVELLE® was approved by Health Canada on March 22, 2018, and is the first gonadotropin to be granted Innovative Drug status by Health Canada.5

"We are proud to lead the way towards a more innovative and personalized care approach for women undergoing IVF," said Lee Ferreira, General Manager, Ferring Pharmaceuticals. "Over the last decade, personalized medicine has led to scientific advancements as medicines become tailored to each patient and their treatment. REKOVELLE® is now the first personalized therapy in fertility available in Canada."

The approval of REKOVELLE® is based on ESTHER-1, a controlled ovarian stimulation (COS) phase 3 non-inferiority clinical trial. The study randomized 1,326 patients from 11 countries, including 152 patients from Canada.1 Patients received a set daily dose of REKOVELLE® based on AMH levels and body weight or a conventional dose of follitropin alfa.1 Approximately 43 per cent of women treated with REKOVELLE® achieved the target ovarian response of 8 to 14 oocytes, compared to 38 per cent of women treated with follitropin alfa.1

The most frequently reported adverse drug reactions (≥1%) with REKOVELLE® in phase 3 program were headache, pelvic discomfort, ovarian hyperstimulation syndrome (OHSS), pelvic pain, nausea, adnexa uteri pain and fatigue.1

About controlled ovarian stimulation

Controlled ovarian stimulation (COS), is the process by which a pharmacological treatment is used to induce the development of multiple eggs during an IVF cycle. COS is generally employed as part of assisted reproductive technologies (ART) such as an in vitro fertilisation (IVF) treatment cycle.7

About ESTHER-1 trial1

The ESTHER-1 trial (Evidence-based Stimulation Trial with Human recombinant FSH in Europe and Rest of World) was a randomised, assessor-blind, controlled, multicentre non-inferiority Phase 3 trial.

ESTHER-1 was a trial of 1,326 patients in 11 countries, including 152 patients from Canada, undergoing their first ART cycle. Patients were randomised 1:1 to receive treatment with a fixed, individualized dose of follitropin delta based on serum AMH levels and body weight or a conventional dose of follitropin alfa. The co-primary endpoints of ongoing pregnancy rates and ongoing implantation rates were met, and results showed no difference between the two treatment arms. Results of the ESTHER-1 trial were published in the February 2017 issue of Fertility & Sterility.

About Ferring Canada

Ferring Canada is the Canadian subsidiary of Ferring Pharmaceuticals. Ferring Canada started its operations in 1987 with just three employees. Today, the company employs nearly 90 employees and sees considerable growth ahead as it continues to bring valuable new products to the Canadian marketplace. The company's therapeutic focus is gastroenterology, urology and reproductive health. Ferring Canada is committed to providing innovative medicines that will help Canadians have a better quality of life in the years to come.

To learn more about Ferring or its products, visit www.ferring.ca.

References

1. REKOVELLE® Canadian Product Monograph, March 22, 2018. Available at ferring.ca.
2. Fauser BC, Diedrich K, Devroey P. Evian Annual Reproduction Workshop Group 2007. Hum Reprod Update. 2008 02 [cited 2018 Jun 14];14:1–14.
3. La Marca A, Sunkara SK. Individualization of controlled ovarian stimulation in IVF using ovarian reserve markers: from theory to practice. Hum Reprod Update. 2014 01 [cited 2018 Jun 14;20:124–40.
4. Steward RG, Lan L, Shah AA, et al. Oocyte number as a predictor for ovarian hyperstimulation syndrome and live birth: an analysis of 256,381 in vitro fertilization cycles. Fertil Steril. 2014 04 [cited 2018 Jun 14];101:967–973.
5. Government of Canada. Register of Innovative Drugs. Available at https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/applications-submissions/register-innovative-drugs/register.html. Accessed August 16, 2018.
6. Ferring- Data on file.
7. Zegers-Hochschild F, Adamnson DG et al. The International Glossary on Infertility and Fertility Care, 2017. Fertil Steril. 2017;108(3):393-406.

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SOURCE Ferring Pharmaceuticals