Opportunity for biotech firms to pursue drug candidates that target metabolic disorders, says GlobalData
Gene therapies have been a point of discussion during the last several years as a potential curative option for a variety of disease indications. The majority of the cardiovascular and metabolic disorder (CVMD) gene therapies in development are targeting cardiovascular indications, indicating immense opportunity for biotech companies to pursue drug candidates that target metabolic disorders, says leading data and analytics company GlobalData.
The company’s report, ‘Gene Therapy in CVMD’ focused on CVMD gene therapies, which included candidates targeting coronary artery disease, critical limb ischemia, diabetic foot ulcers and Pompe Disease, and that are in development in the eight major markets (8MM; the US, France, Germany, Italy, Spain, the UK, Japan and urban China). The report found that big pharma companies lag behind small bio-techs in R&D efforts.
In addition, the report reveals that, despite investment in CVMD gene therapies, the majority of the candidates across the 8MM are still in early R&D stages, whereas only a handful of CVMD gene therapies are in Phase II or Phase III clinical trials.
Within the entire CVMD space, the current gene therapy pipeline features approximately 13 candidates that are in Phase I, II or III of clinical development. Only three gene therapies have reached Phase III trials: AnGes MG’s Collategene, Angionetics’ Generx and ViroMed’s donaperminogene seltoplasmid.
Pavan Kottamasu, Healthcare Analyst at GlobalData, says: “Of the pipeline CVMD gene therapies, the majority of them target cardiovascular indications such as coronary artery disease, peripheral artery disease, critical limb ischemia, and systolic heart failure, indicating a massive opportunity for biotech companies to develop drug candidates that target metabolic disorders.”
Key opinion leaders interviewed by GlobalData anticipate big pharma companies to partner with these smaller biotech companies to enhance development of gene therapy candidates within the next decade.
IKARIA Resort Wear Limited-Edition Havana Night's Capsule Dazzles with Crystals from Swarovski®
Los Angeles, CA - July 24, 2018 - LA-based resort wear brand, IKARIA Resort Wear, channels the flair of Cuba for their Destination Cuba Resort 2019 collection. Old Hollywood glamour with a Cuban flair can be felt throughout the ethereal luxe 100% Silk 20-piece collection, designed to effortlessly transition from beach to dinner to the red carpet. Founder, Lisa Storie chose two key styles created with crystals from Swarovski® to highlight the beauty of Cuba and to elevate the designs. Havana Nights' Giselle and Lucia will be available for special order only.
The Ikaria Resort Wear 2019 Havana Nights Capsule transports us to the magical Island of Cuba. These One-of-a-Kind Designs are dazzling with Crystals fromSwarovski®. Ikaria Resort Wear's 100% Silk designs float easily from resort to dinner to the red Carpet inspiring our Havana Nights styles.
Old Hollywood glamour and the flair of Cuban salsa can be seen in the flirty side ruffle slits of the Giselle. The easy movement and comfort of this dress and the open, adjustable back tie make for a style that is sexy, glamorous and feels light and airy against the skin as you dance through sultry Cuban nights. The white sandy beaches and sparkling sea of Cayo Coco, Cuba inspired the Giselle in white 100% Silk Georgette adorned with Swarovski® Crystals. The crystal detail is created with a plethora of Crystals from Swarovski® ® in a multitude of sizes reminiscent of stars dancing across the Cuban sky.
The Lucia's svelte silhouette and exclusive Ikaria crystal design is created with Swarovski® Crystals on the front and back bodice of the dress reminiscent of Art Deco, an architectural theme visually echoed throughout the historic streets of Havana, Cuba. Lucia's elegant lines lead to a center slit that is both sexy and demure and allows for ease of movement as you glide across the dance floor. The magical night sky inspired the various shades of crystals delicately laid against the black 100% Silk Georgette design.
Ikaria Resort Wear's collection is designed and produced in downtown Los Angeles. The resort wear is made from 100% silk, making the styles lightweight and easy to slip on. The collection will be available on
www.IkariaResortWear.com. The exclusive styles featuring the Swarovski® Crystal designs will be available for special order.
| Alzheimer’s-related Study: Brain Training Upregulates Acetylcholine
(Chicago, IL) – A small study could have big implications in the battle against age-related cognitive decline and dementia, according to research announced today at the Alzheimer’s Association International Conference. The study was conducted by researchers at McGill University and Posit Science, and showed— for the first time ever in humans — that a particular type of brain exercise can increase the ongoing production of a brain chemical that is critical in addressing Alzheimer’s disease.
The brain chemical is acetylcholine, a neuromodulator, which the brain naturally produces at the moments when it needs to attend to information, and which is critical to memory and learning. Typically, the production of acetylcholine decreases with aging, and is more dramatically decreased in people with age-related cognitive decline, pre-dementia, and dementia.
The most commonly-used drugs to combat early stage Alzheimer’s are cholinesterase inhibitors (e.g., Aricept, Exelon, Razadyne), which decrease the rate at which the brain breaks down acetylcholine, leading to higher levels of acetylcholine in the brain. This strategy has been shown to mildly slow the decline associated with Alzheimer’s disease, but typically the benefits from this strategy are not sustainable over time.
“When we train rats to attend, we can reverse the downward spiral in acetylcholine production from aging, and up-regulate its natural production at the precise moment needed,” said Dr. Michael Merzenich the Chief Scientific Officer of Posit Science and Kavli Laureate in Neuroscience. “This is the first confirmation in humans that this more organic strategy can work, leading to higher levels of acetylcholine even in a resting state. Now, we need to perform larger studies in at-risk, pre-dementia, and dementia populations.”
The pilot, single-arm study collected baseline PET imaging on the production of acetylcholine from 5 older adults, who then completed a total of 12 hours of computerized training on iPads (in 4-5 sessions per week of 30 minutes each, over 5-6 weeks), and, then, were imaged again. The PET imaging showed an upregulation of acetylcholine of 16-24% in four areas across the forebrain (right inferior frontal gyrus, left caudate nucleus, bilateral medial prefrontal cortex, and left lingual gyrus/Cuneus). This mirrored behavioral results showing improved attention.
The proprietary exercise used in the study presents a user with a target image, and then shows the user a series of images, with each presented for a split-second. If the presented image does not match the target, the user responds by tapping (a key or screen), but if the image does match the target, the user withholds a response (not tapping).
The exercise is designed to be attentionally-demanding—driving both focus and suppression of distraction. A commercialized version of the exercise is found exclusively in the BrainHQ web and mobile apps from Posit Science, and is known as the “Freeze Frame” exercise.
The exercise was designed by Dr. Tom Van Vleet of Posit Science and Dr. Joe DeGutis of Harvard Medical School. The acetylcholine imaging was conducted in the lab of Dr. Etienne de Villiers-Sidani of McGill University.
Two years ago at the same conference, researchers from the 10-year, 2800-person ACTIVE Study presented results that showed those who trained with an exercise licensed exclusively by Posit Science had a 29-48% reduced risk of dementia (depending on the amount of training and the categorization of dementia). Those results increased interest in the mechanisms of action that cause plasticity-based brain exercises to be effective.
“Just as physical exercise unleashes multiple mechanisms to drive better physical health, plasticity-based brain exercise drives many key mechanisms, in concert, to drive better brain health,“ observed Dr. Henry Mahncke, CEO of Posit Science. “Recent studies have shown increased white matter integrity, increased neural connectivity and efficiency, increased hippocampal activation, increased beta-band activation, improved performance in the Central Executive Network, and stabilization of the Default Mode Network. This first demonstration of increased production of acetylcholine is perhaps the most significant development, not just because of its application to Alzheimer’s, but to a host of other conditions as well.” |
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Delta 9 Applauds Manitoba Cannabis Retail Expansion
/NOT FOR DISSEMINATION IN THE UNITED STATES OR FOR DISTRIBUTION TO U.S. WIRE SERVICES/
WINNIPEG, July 24, 2018 /CNW/ - DELTA 9 CANNABIS INC. (TSXV: NINE) ("Delta 9" or the "Company") confirms it will be applying for a license to open more cannabis retail outlets in Manitoba, as part of the second phase of retail cannabis expansion announced yesterday by the Manitoba Government.
Growth, Enterprise and Trade Minister Blaine Pedersen announced Monday, July 23, that his government will issue a second public tender for companies that wish to build and operate cannabis retail stores across the Province. Mr. Pedersen said the intention is to ensure that within the first two years of legalization, 90 per cent of Manitobans will be able to access legal cannabis within a 30-minute drive or less.
"In proceeding with phase two of our retail strategy, we are keeping our promise to establish a competitive retail environment that creates new economic opportunities for all Manitobans," said Pedersen.
Delta 9 CEO John Arbuthnot says he's happy to see the Manitoba Government pushing forward on the second phase of retail expansion.
"As one of the most experienced cannabis companies in Canada, and one of only two cannabis companies based in Manitoba, we feel we are uniquely qualified to provide this important product and service, and to provide more economic development and employment for the people of Manitoba," Arbuthnot said.
The Company has already secured locations for its first four retail stores, two of them in Winnipeg, one in Brandon, and the fourth in Thompson. Arbuthnot says he doesn't know yet how many retail stores will be allowed in the second phase of the program, but adds the Company would be prepared to open up to an additional dozen stores in 2019.
"As a local company, we want to be able to serve the people of Manitoba in every corner of the Province," Arbuthnot said. "It's clear from the Minister's remarks that he is concerned more remote communities may not be well served, so we're committing that as part of our program, we will absolutely build a network that includes smaller rural communities as soon as possible.
"We are fully funded to expand our operations throughout Manitoba, and to increase our production to meet demand," Arbuthnot added.
The Manitoba Government will first issue a Request for Pre-Qualifications (RFPQ) which companies can respond to by August 31, 2018. Companies must first qualify to become a candidate for retail store licenses, and will then be eligible to apply for a license under a Request for Proposals.
Delta 9 is among the companies that have already qualified as a retail license holder in Manitoba. Mr. Pedersen confirmed yesterday that retailers who submitted proposals under the initial public tender will be eligible for the current RFPQ process.
About Delta 9 Cannabis Inc.
Delta 9's wholly-owned subsidiary, Delta 9 Bio-Tech Inc., is a licensed producer of medical marijuana pursuant to the ACMPR and operates an 80,000 square foot production facility in Winnipeg, Manitoba, Canada. Delta 9's shares trade on the TSX Venture Exchange under the symbol "NINE".
Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.
Disclaimer for Forward-Looking Information
Certain statements in this release are forward-looking statements, which reflect the expectations of management regarding the Company's future business plans and other matters. Forward-looking statements consist of statements that are not purely historical, including any statements regarding beliefs, plans, expectations or intentions regarding the future. Forward looking statements in this news release include statements relating to: (i) Delta 9's expansion plans; (ii) Delta 9's production of cannabis; (iii) approvals for Delta 9's production facilities by Health Canada; (iv) demand for Delta 9's products; and (v) Delta 9's cost to produce its grow pods. Such statements are subject to risks and uncertainties that may cause actual results, performance or developments to differ materially from those contained in the statements, including that Delta 9's currently contemplated expansion and development plans may cease or otherwise change, Delta 9's production of cannabis may be lower than expected, Delta 9 may not obtain the required approvals from Health Canada, demand for Delta 9's products may be lower than anticipated, Delta 9's cost to produce its grow pods may be higher than expected and all other risk factors set forth in the filing statement of Delta 9 dated October 25, 2017 which has been filed on SEDAR. No assurance can be given that any of the events anticipated by the forward-looking statements will occur or, if they do occur, what benefits the Company will obtain from them. Readers are urged to consider these factors carefully in evaluating the forward-looking statements contained in this news release and are cautioned not to place undue reliance on such forward-looking statements, which are qualified in their entirety by these cautionary statements. These forward-looking statements are made as of the date hereof and the Company disclaims any intent or obligation to update publicly any forward-looking statements, whether as a result of new information, future events or results or otherwise, except as required by applicable securities laws.
SOURCE Delta 9 Cannabis Inc.
Women, Alcohol Abuse
And 4 Coping Skills For Recovery
A recent study that showed even moderate alcohol consumption can take years off your life not only attracted a lot of media attention, it also caused other studies about drinking to seem even more worrisome, especially with their findings about women.
We aren’t talking about harmless social sipping with friends here, and as the nation observes Women’s Health Care Month in May it’s worth exploring the growing negative role that alcohol plays in the lives of American women.
“My favorite line of all time is: ‘I don’t drink that much,’ ” says Dr. Soroya Bacchus (www.soroyabacchusmd.com), a psychiatrist and author of How to Detox Yourself from Alcohol.
“Sometimes the people who say this are right; they really don’t drink that much. More often, though, people say this to make themselves feel better about how much they do drink.”
Just last year, a study published by JAMA Psychiatry reported that more Americans are drinking high amounts ofalcohol, and some of the greatest increases are among women.
In addition, about 5.3 million women in the United States drink alcohol in a way that threatens their health and safety, according to the National Institute on Alcohol Abuse and Alcoholism.
For those women, just trying to get sober won’t fix the fundamental problem that caused them to drink too much to begin with, Bacchus says.
“I don’t care about sober,” she says. “I care about healthy. No one drinks or uses drugs in a vacuum. Usually there is an underlying mental disorder that causes and worsens the alcohol or drug use.”
It’s important that women with serious drinking problems seek medical assistance so they can detox in a safe manner, Bacchus says. Detoxification from alcohol has more complications from withdrawal than any other drug, and the death rate for alcohol withdrawal is between 5 and 8 percent, she says.
Even after detoxing, Bacchus says, a therapist can help women develop healthy psychological coping skills to avoid a relapse.
Among the ways they can do that include:
- Biofeedback therapy. This teaches you to develop voluntary, conscious control of physiological processes that are typically involuntary and unconscious. “If you have alcohol cravings, biofeedback teaches you how to identify the physical sensations associated with them and allows you to deploy strategies to counter them,” Bacchus says.
- Hypnosis or hypnotherapy. Through hypnosis a therapist can explore the potential root causes of alcoholabuse, such as previously unknown disorder, a hidden memory or a past trauma. Bacchus offers a caveat: Only undergo hypnotherapy with a trained professional you trust completely.
- Exercise. Every time you exercise you build yourself up both psychologically and physically, Bacchus says. “Before you know it, you have a positive habit that sustains you through tough times,” she says. “Instead of taking a drink, you go for a walk. Instead of falling into a rabbit hole of negative emotion, you hit the gym.”
- Yoga. Yoga is both a great exercise for muscles and joints, but also an excellent way to deal with stress. “This makes it a perfect practice for recovery,” Bacchus says, “because you need to rebuild your body from the ravages of alcohol abuse and rebuild your mind from the negative thought patterns you developed over years of addiction.”
“The goal is to replace the negative coping mechanisms of addiction with the healthy coping mechanisms of recovery,” Bacchus says. “You need your mind and body working in harmony so your soul can be at peace.”
About Soroya Bacchus, M.D.
Soroya Bacchus, M.D., (www.soroyabacchusmd.com) author of How to Detox Yourself from Alcohol, is a triple board-certified psychiatrist specializing in addition and psychosomatic medicine. She has treated patients with addiction issues for 22 years. She has been interviewed on such television shows as Good Morning America and has been quoted in the New York Times, the Huffington Post and other print and online publications.
Novus Health and iA Financial Group Team Up to Make a Difference in Health Literacy
TORONTO, July 24, 2018 /CNW/ - Novus Health is pleased to announce that it has partnered with iA Financial Group. Through this new partnership, iA Financial Group is offering its group insurance clients the tools their plan members need to better understand their health, pursue wellness and make informed decisions.
For many Canadians, health literacy remains a challenge: it can be overwhelming to navigate Canada's complex health care systems and understand their options. What's more, when searching online for answers to health questions, Canadians report trouble finding reliable, relevant information. All this can make the search for health information a frustrating, time-consuming process that leaves many simply wanting to speak to someone.
This is where Novus Health comes in. Novus Health provides personalized access to discuss their questions by phone with Health Information Specialists, along with 24/7 access to online and mobile platforms with relevant and curated health information and resources. The platform's interactive, engaging tools help members take control of their health and empower them to become their own advocates within the health care system.
How Novus Health Products are Enhancing Health Management
The Health Navigation Platform provides an interactive experience that removes barriers from the search for health information. Alongside comprehensive web and mobile access to health resources and tools to find doctors and clinics in your area, Novus Health offers live telephone support from trained Health Information Specialists and nurses who can provide personalized information and guidance. Both the platform and the telephone support line are fully bilingual.
Through a user-responsive questionnaire, the Health Risk Assessment tool can provide a snapshot of a population's health risks, and enables members to make informed choices by giving them a personalized health report with clear explanations of their condition, helpful local resources, and action plans addressing their unique situation. The program can also assess their needs on an ongoing basis, helping them adapt to their changing health status.
Stay Healthy at Work is a unique absence and disability avoidance program that targets the common sources of workplace absence, while at work. The program gives members the ability to connect to a health coach (trained registered nurses and other physical and mental health professionals) who can help them manage their health issue before it becomes severe. The program's proactive, behaviour-change-focused intervention makes it a cost-effective alternative to traditional Employee Assistance Programs for organizations who want to minimize disability and absenteeism, reduce costs, and provide holistic support services to their employees.
With the full range of enhancements from Novus Health to offer all of its group insurance clients going forward, iA Financial Group is giving members the power to improve their health literacy, health outcomes, wellness and quality of life.
About Novus Health
Novus Health is an information and technology-enabled health and wellness services provider. The leader in health navigation and wellness solutions, Novus Health helps organizations make health information and health care more accessible, understandable, and effective for their members and clients. Novus Health's solutions are provided to over 5 million people, with offices located in Toronto, Montreal, Vancouver, Los Angeles and Paris.
For more information, visit www.novushealth.com and www.novussante.com.
SOURCE Novus Health
United Health Foundation, UH Expand Obesity and Diabetes Program
Partnership Moving into Houston’s East End after Success in Third Ward
HOUSTON, July 24 – Midway through a three-year, $2 million grant from the United Health Foundation, University of Houston’s Project TOUCH (Treating Obesity in Underserved Communities) has impressive numbers to report. Based on its success in Houston’s Third Ward, the effort for preventing and treating obesity, Type 2 diabetes and other ailments will move into Houston’s East End in the fall.
Under the direction of professors Ezemenari Obasi and Dan O’Connor, fellows at the UH institute fighting health disparities called UH HEALTH (Helping Everyone Achieve a Life Time of Health) Research Institute, the community collaborative program is reporting:
- 1,350 total patients
- Prevention and screenings: 1,159
- Treatment: 207
- UH BOUNCE Childhood Obesity Program: 147 families
- Patients referred to YMCA’s Diabetes Prevention Program: 60
Margaret’s success story
Third Ward resident Margaret Jefferson is counted among those whose lives have changed because of the program. After 35 years as a teacher and 15 more as a registered nurse, she knew how to educate others, but when it came to her own health, she struggled. And slowly through the years, the pounds just seemed to creep up on her. Then in early 2017 Margaret, diagnosed as pre-diabetic at 190 pounds, heard about the YMCA’s Diabetes Prevention Program provided through the new Project TOUCH at the Houston Texans YMCA on Griggs Road. That’s the nature of Project TOUCH, it pops up in churches, community centers and other partner outlets.
“I’ve become so aware of what I put in my mouth now,” said Margaret, admitting a typical breakfast before the program consisted of three slices of bacon, a couple of eggs, grits, toast and “lot and lots” of butter or margarine. Not anymore.
“I think I’ve lost my taste for it in view of what my goals are now and I feel better. Now I eat a half a cup of oatmeal, a good grain bread and I monitor my fat intake. The program has taught me that what I put in my mouth is medicine for my body,” she said. For Margaret, the medicine is working – she’s dropped more than 40 pounds since attending.
According to the Centers for Disease Control and Prevention, 72 percent of African Americans in Houston are overweight or obese.
“When we go into the communities we’re finding a high proportion of the people we are screening have high risk for type 2 diabetes,” said Obasi, adding that risk factors include chronic exposure to stress, lack of insurance to cover medical expenses, intergenerational poverty and medical deserts.
“There aren’t a whole lot of mental or physical health services built into the community,” said Obasi. “Our primary goal is to integrate health care and offer prevention and treatment.” During a patient’s visit a referral might be made to the Diabetes Prevention Program or to seek treatment at federally qualified health clinics that partner with Project TOUCH.
In addition to the YMCA’s Diabetes Prevention Program through Project TOUCH classes, Project TOUCH provides health fairs and screenings and a program to train the trainers, providing community leaders with tools they can use to better serve their neighbors.
“The training is based on what their needs are, so we’ve created a menu of different types of skill sets that we share,” said Obasi. They have trained personnel at Change Happens, a nonprofit that transforms lives of families and children in high risk communities, in motivational interviewing so their staff has the capacity to increase the motivation of those they are serving.
Program expansion
During the next half of the grant’s timetable, the researchers will replicate and expand the community coalition and interventions into Houston’s underserved East End population to not only demonstrate scalability of the overall program, but also to meet another critical need: The CDC reports 78 percent of Latinos in Houston are overweight or obese.
“With the expanding success in Third Ward, we are looking forward to moving into East End,” said O’Connor. “We have a number of community partners who are excited to get started there, so I’m expecting good success there, as well.”
“On behalf of the nearly 18,000 UnitedHealthcare employees in Texas, we are grateful for the opportunity to partner with a leading organization like University of Houston to address this important public health issue,” said Dave Milich, CEO, UnitedHealthcare of Texas. “We know many Houstonians are facing diabetes and related chronic health issues, and we’re eager to see our partnership expand to help more of our neighbors live healthier lives.”
The ultimate objective is to create a model that can be duplicated and sustained not only in communities across the greater Houston area, but also throughout Texas and the United States.
Margaret says she’s “thrilled” to see the program expand into Houston’s East End, eager to see others learn how to take control of their own lives by making better choices.
“Balance in our lives keeps us from going to extremes,” she said. “I’ve recognized that my food choices, the simple act of picking up an apple rather than a potato chip, makes me realize I can make better choices in the finer details of life.”
About the University of Houston
The University of Houston is a Carnegie-designated Tier One public research university recognized with a Phi Beta Kappa chapter for excellence in undergraduate education. UH serves the globally competitive Houston and Gulf Coast Region by providing world-class faculty, experiential learning and strategic industry partnerships. Located in the nation's fourth-largest city and one of the most ethnically and culturally diverse regions in the country, UH is a federally designated Hispanic- and Asian-American-Serving institution with enrollment of more than 45,000 students.
Take a Brain-check with The Mind Makeover Retreat™
Change your life in ways you may never have thought possible on The Mind Makeover Retreat™, the latest pioneering retreat launched by Health and Fitness Travel, the wellness holiday specialists. Led by international master of mind-improvement and celebrity coach, Steve McKeown, this ground-breaking wellness retreat promotes positive mental well-being and launches this September at the luxurious Macdonald Monchique Resort & Spa, in the western Algarve.
A healthy mind lives in a healthy body and mental health is imperative for physical well-being. It’s estimated that 1 in 4 adults in England experience mental health problems in any given year. With longer working hours and increasing pressures, both professionally and personally, mental health issues are more prevalent than ever. This unique psychological programme works by combining state-of-the-art tools to improve your personal and professional performance, and achieve your full potential.
Whether you suffer from anxiety, brain fog, weight or sleep issues, lack of direction, or are simply in need of a recharge, this life-changing retreat will break down the barriers that are keeping you from success, and kick-start your journey to becoming your best self. Unmanaged thoughts adversely affect our energy and physical health and the connection between our brain and immune system is proven; not managing your thinking and beliefs is detrimental to your health and well-being.
Speaking about the motivation behind The Mind Makeover, Steve McKeown says; “I wanted to design a retreat with Health and Fitness Travel that is unique and has never been available before, a retreat that will not only be extremely relaxing and fun but will enable you to regain control of your cognition, challenge your assumptions and rid you of those limitations that have held you back in your life. Being away from the distractions and stresses of normal daily life that can sometimes cause restraints, makes our retreat at Macdonald Monchique the perfect environment for change”.
Macdonald Monchique Resort and Spa is beautifully secluded amid lush green woodlands and towering mountains in the western Algarve. This ever-sunny destination offers breath-taking panoramic coastal and alpine views away from busy built up tourist areas and is near stunning beaches and the beautiful old village of Monchique. The Mountain of Monchique is the region's favourite mountain for hiking in nature.
Retreat participants will have full access to Macdonald Monchique’s luxury spa facilities, four dynamic restaurants, invigorating group therapy work, a personal spa treatment and group fitness activities. Guests may wish to partake in complimentary daily activities including dance and aqua-fun or enjoy a morning walk surrounded by stunning views of the coast and mountains, or simply unwind in the elegant and tranquil environment.
A seven-night break at Macdonald Monchique on The Mind Makeover Retreat costs £2,385pp based on 2 people sharing, or £2,750pp for single occupancy. Price includes accommodation, full board, return flights, private transfers and The Mind Makeover programme.
Zogenix is set to become a key player in the epilepsy market following positive results for ZX008, says GlobalData
Zogenix’s positive results for its drug ZX008 (fenfluramine hydrochloride) and the subsequent approval that is likely to follow, will push Zogenix to become a key player in the epilepsy market, according to GlobalData, a leading data and analytics company.
Zogenix will treat young children and adolescents suffering from Dravet syndrome. The results will allow Zogenix to push ahead with its plan to submit regulatory filings in the US and EU markets in Q4 2018, swiftly following GW Pharmaceutical’s Epidiolex (cannabidiol).
GlobalData’s report: ‘PharmaPoint: Epilepsy – Global Drug Forecast and Analysis to 2026’, highlights that Dravet syndrome is a rare form of pediatric epilepsy that has proved difficult to treat, with current therapies showing poor efficacy, safety, or tolerability profiles. As such, treatments for this form of epilepsy are one of the more significant needs in the epilepsy market.
Rahael Maladwala, Pharma Analyst at GlobalData, comments: “Moving forward, the company has stated that it expects to file a regulatory submission in the US and EU by the end of the year, with a view to launch by the end of 2019.
“However, with trials also running in patients suffering from Lennox-Gastaut syndrome (LGS) and the epilepsy market lacking effective therapies, it is likely that Zogenix will continue to file for approval in other epilepsy patient populations after Dravet syndrome.”
The timing of ZX008’s approval will likely elicit competition with GW Pharmaceutical’s Epidiolex, which was approved by the FDA last month for the treatment of Dravet syndrome and LGS patients. While Epidiolex has already been approved in the US, the molecule has a controversial mechanism of action, as it is a pure extract from cannabis. Consequently, Epidiolex has to overcome further regulatory hurdles set by the Drug Enforcement Agency (DEA), which will delay its launch.
Maladwala adds: “ZX008 has already been used in a compassion program in Belgium, and therefore has proven efficacy in a real-world setting, which may sway the decision of some physicians. Realistically, the high unmet need for effective treatments in pediatric epilepsies such as Dravet syndrome and LGS mean that both drugs will likely experience a quick uptake and command a large market share in these patient populations.
“All that remains to be seen now is whether or not the company can formulate an effective marketing strategy as well as a favorable pricing and reimbursement position that will maximize sales of ZX008 and encourage its uptake over Epidiolex.”
Morneau Shepell opens crisis line to support those affected by Toronto's Danforth shooting
Company's 24/7 free crisis hotline available now to those in need: 1.844.751.2133
TORONTO, July 23, 2018 /CNW/ - As a result of the tragic shooting that occurred in Toronto's Greektown neighbourhood on Sunday, July 22, Morneau Shepell has opened its 24/7 bilingual crisis support hotline to help anyone affected by the traumatic event.
"Our deepest sympathies and thoughts are with the families and loved ones of the individuals who lost their lives, and our thoughts continue to be with the Greektown community as they cope with yesterday's tragic event," said Stephen Liptrap, president and chief executive officer, Morneau Shepell. "The Danforth, and all communities across Toronto, should be a place where people feel safe to enjoy an evening with friends and family. As a part of this vibrant city, we're devastated by the recent spike in gun violence and are committed to helping those affected. As such, we have opened our free 24/7 bilingual crisis hotline and encourage those seeking support to reach out."
A crisis or traumatic event can trigger overwhelming emotional responses. Morneau Shepell's national 24/7 crisis support line offers professional emotional support to anyone in crisis. When calling the crisis line, individuals receive crisis counselling support and/or referral to community resources. Anyone affected by the incident in Toronto can reach the free crisis support line at 1.844.751.2133.
The Company's employee assistance program is also available to existing clients through the designated toll-free number or by visiting workhealthlife.com.
About Morneau Shepell
Morneau Shepell is the only human resources consulting and technology company that takes an integrated approach to employee assistance, health, benefits and retirement needs. The Company is the leading provider of employee and family assistance programs, the largest administrator of retirement and benefits plans and the largest provider of integrated absence management solutions in Canada. As a leader in strategic HR consulting and innovative pension design, the Company helps clients solve complex workforce problems and provides integrated productivity, health and retirement solutions. Established in 1966, Morneau Shepell serves approximately 20,000 clients, ranging from small businesses to some of the largest corporations and associations. With more than 4,000 employees in offices across North America, Morneau Shepell provides services to organizations across Canada, in the United States and around the globe. Morneau Shepell is a publicly-traded company on the Toronto Stock Exchange (TSX: MSI). For more information, visit morneaushepell.com.
SOURCE Morneau Shepell Inc.
