Clinical Trials, Price & Excise Tax Relief, and Worldclass Leadership Underpin Commitment to Patients and Healthcare Professionals

SMITHS FALLS, ON, June 12, 2018 /CNW/ - Canopy Growth Corporation (TSX: WEED) (NYSE: CGC) (the "Company" or "Canopy Growth") is pleased to provide the following updates on its medical cannabis program and to re-affirm its strong commitment to medical cannabis, the patients who depend on it, and the Healthcare Professionals who prescribe it.

HISTORIC CLINICAL TRIAL MILESTONES

Marking a major milestone for medical cannabis in Canada, a Phase IIb "in-human" clinical trial application was submitted by Canopy Health Innovations Inc. to evaluate the use of medical cannabis in the treatment of insomnia. Having received approval to proceed with these clinical trials in the form of a No Objection Letter (NOL) from Health Canada, Canopy Health will now proceed with these robust clinical trials, in collaboration with a leading Canadian research institution.

In light of the significant potential for cannabis in treating  a range of medical conditions, this is the first in a planned series of trials to investigate and quantify the therapeutic effect of cannabis and cannabinoids across a selection of indications with significant unmet needs, working towards the ultimate goal of patented, insurance-eligible cannabinoid-based medicines.

WORLDCLASS LEADERSHIP FOR A GLOBAL INDUSTRY

As previously announced, starting in July 2018, Dr. Mark Ware will commence his role as the Company's Chief Medical Officer. Under his leadership the Company will continue to lead the global medical cannabis industry forward with a focus on research, product innovation, and stakeholder education in the numerous regions where Spectrum Cannabis operates, including Latin America, Australia, Europe and North America.

PATIENTS-FIRST PRICING MENTALITY

Honouring our commitment to affordable medical cannabis and pricing predictability for patients, Canopy Growth is pleased to inform  patients  that, upon the passing of the Cannabis Act, the Company will absorb the proposed excise tax on all Spectrum Cannabis products sold in Canada. Affordability is a key consideration for patients. It is important today to show leadership and reduce the price burden placed on our customers,while we work towards insurance eligibility for medical cannabis.

On top of this, all Spectrum Cannabis dried flower products will be priced at $8.50 per gram or less. If a registered customer is currently paying more for a Spectrum flower product this means new savings, and if they are paying less that price will remain the same. As always, Spectrum Cannabis products available online through TweedMainStreet.com are eligible for our industry-first Compassionate Pricing Program that assists those on limited incomes afford their medicine.

"Using Canada's rich eco-system of researchers and established cannabis stakeholders as a centre of expertise, Spectrum's global expansion is rooted in sophistication," said Mark Zekulin, President, Canopy Growth. "We are proudly a research and patient focused company that will continue to drive the cannabis innovation agenda forward around the world."

Here's to Future Growth.

About Canopy Growth Corporation

Canopy Growth is a world-leading diversified cannabis and hemp company, offering distinct brands and curated cannabis varieties in dried, oil and Softgel capsule forms. From product and process innovation to market execution, Canopy Growth is driven by a passion for leadership and a commitment to building a world-class cannabis company one product, site and country at a time.

Canopy Growth has established partnerships with leading sector names including cannabis icon Snoop Dogg, breeding legends DNA Genetics and Green House seeds, and Fortune 500 alcohol leader Constellation Brands, to name but a few. Canopy Growth operates ten licensed cannabis production sites with over 2.4 million square feet of production capacity, including over 500,000 square feet of GMP-certified production space. The Company has operations in eight countries across four continents. The Company is proudly dedicated to educating healthcare practitioners, conducting robust clinical research, and furthering the public's understanding of cannabis, and through its partly owned subsidiary, Canopy Health Innovations, has devoted millions of dollars toward cutting edge, commercializable research and IP development. Through partly owned subsidiary Canopy Rivers Corporation, the Company is providing resources and investment to new market entrants and building a portfolio of stable investments in the sector. From our historic public listing on the Toronto Stock Exchange and New York Stock Exchange to our continued international expansion, pride in advancing shareholder value through leadership is engrained in all we do at Canopy Growth. For more information visit www.canopygrowth.com

Forward Looking Statement

This news release contains "forward-looking statements" within the meaning of the United States Private Securities Litigation Reform Act of 1995 and "forward-looking information" within the meaning of applicable Canadian securities legislation. Often, but not always, forward-looking statements and information can be identified by the use of words such as "plans", "expects" or "does not expect", "is expected", "estimates", "intends", "anticipates" or "does not anticipate", or "believes", or variations of such words and phrases or state that certain actions, events or results "may", "could", "would", "might" or "will" be taken, occur or be achieved. Forward-looking statements or information involve known and unknown risks, uncertainties and other factors which may cause the actual results, performance or achievements of Canopy Growth or its subsidiaries to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements or information contained in this news release. Risks, uncertainties and other factors involved with forward-looking information could cause actual events, results, performance, prospects and opportunities to differ materially from those expressed or implied by such forward-looking information, including pricing, clinical trial execution, the planned acquisition of Canopy Health Innovations, and such risks contained in the Company's annual information form dated June 28, 2017 and filed with Canadian securities regulators available on the Company's issuer profile on SEDAR at www.sedar.com. Although the Company believes that the assumptions and factors used in preparing the forward-looking information or forward-looking statements in this news release are reasonable, undue reliance should not be placed on such information and no assurance can be given that such events will occur in the disclosed time frames or at all. The forward-looking information and forward-looking statements included in this news release are made as of the date of this news release and the Company does not undertake an obligation to publicly update such forward-looking information or forward-looking information to reflect new information, subsequent events or otherwise unless required by applicable securities laws.

Program is on track for clinical trial start in H2 2019

TORONTO and CAMBRIDGE, MA, June 12, 2018 /CNW/ - ProMIS Neurosciences, Inc., a biotechnology company focused on the discovery and development of precision treatments for neurodegenerative diseases, today announced the initiation of producer cell line development for PMN310, its lead therapeutic antibody candidate for treatment of Alzheimer's disease (AD). Selexis, SA will carry out this critical first step in the manufacturing of antibody therapeutics using the proprietary Selexis SUREtechnology Platform™.

ProMIS' lead antibody product candidate, PMN310, is a humanized antibody that binds with high affinity and selectivity for the toxic oligomers of amyloid beta (Aβ), a recognized root cause of AD. PMN310 is anticipated to enter phase I clinical trials in the second half of 2019.

"We recently completed successful affinity maturation of PMN310, which in addition to its unique and highly selective binding profile offers increased opportunity for best in class therapy for Alzheimer's disease," said Dr. Elliot Goldstein, ProMIS President and CEO. "We are now initiating the manufacturing process with Selexis' proprietary, high-performance technology platform for cell line development based on its proven track record for rapid and stable production of antibody therapeutics such as PMN310."

Selexis' proprietary and high performance SUREtechnology Platform facilitates the rapid, stable and cost-effective production of virtually any recombinant protein including those that are difficult to express in other systems.

"It is rewarding for us to leverage the fast speed/timelines and superior performance of the Selexis platform to rapidly and predictably advance PMN310 into the clinic with the goal of supporting ProMIS Neurosciences as they seek to bring a much needed treatment option to patients with Alzheimer's disease," said Yemi Onakunle, PhD, Selexis vice president, business development and licensing. "We believe our best-in-class technology can help propel forward this best-in-class therapeutic candidate."

About Selexis SA

Selexis SA is a pioneering life sciences company and a global leader in mammalian (suspension-adapted CHO-K1) cell line generation, providing unparalleled proprietary technology and the highly specialized expertise that is necessary to translate scientific innovation into life-saving medicines for patients. Selexis' SUREtechnology Platform™ facilitates the rapid, stable, and cost-effective production of virtually any recombinant protein and provides seamless integration of the bioproduction continuum, spanning discovery to commercialization. With more than 100 partners worldwide, more than 100 drug products in clinical development and three commercial products utilizing Selexis-generated cell lines, the Company has a history of empowering scientists and biopharmaceutical companies around the world to realize the full potential of their research. More information is available at www.selexis.com.

About ProMIS Neurosciences, Inc.

ProMIS Neurosciences is a development stage biotechnology company focused on discovering and developing precision medicine therapeutics to treat neurodegenerative diseases, in particular Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). The Company's proprietary target discovery engine is based on the use of two complementary techniques. The Company applies its thermodynamic, computational discovery platform—ProMIS™ and Collective Coordinates — to predict novel targets known as Disease Specific Epitopes (DSEs) on the molecular surface of misfolded proteins. Using this unique precision medicine approach, the Company is developing novel antibody therapeutics for AD, ALS and PD.  ProMIS is headquartered in Toronto, Ontario, with offices in Cambridge, Massachusetts. ProMIS is listed on the Toronto Stock Exchange under the symbol PMN.TO, and on the OTCQB Venture Market under the symbol ARFXF.

For further information please consult the Company's website at:  www.promisneurosciences.com

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Neither the TSX nor its Regulation Services Provider (as that term is defined in the policies of the TSX) accepts responsibility for the adequacy or accuracy of this release.  This news release contains certain "forward-looking statements" within the meaning of Canadian securities legislation. Forward-looking statements are statements that are not historical facts; they are generally, but not always, identified by the words "expects", "plans", "anticipates",  believes", "intends", "estimates", "projects", "aims", "potential", "goal", "objective", "prospective", and similar expressions, or that events or conditions "will", "would", "may", "can", "could" or "should" occur. Forward-looking statements are based on the beliefs, estimates and opinions of the Company's management on the date the statements are made and they involve a number of risks and uncertainties. Consequently, there can be no assurances that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Except as required by the securities disclosure laws and regulations applicable to the Company, the Company undertakes no obligation to update these forward-looking statements if management's beliefs, estimates or opinions, or other factors, should change.

Delta 9 Legal Lager is now on sale at MLLC liquor outlets across the province, and is the first beer produced as a collaboration between a brewery and a legal cannabis company. Delta 9 provided the raw hemp material for the beer while Fort Garry Brewing is responsible for production and marketing. Both companies shared the cost of research and development.

Legal Lager is an alcoholized beer infused with material from hemp seeds, and therefore contains no cannabis or any other psychoactive agent produced from the cannabis plant. However, the hemp beer released this week is a first step in an ongoing research and development project to jointly produce a cannabis beer that contains THC.

The two companies are currently developing a co-branded, cannabinoid-infused beer that contains no alcohol. Release of that Phase 2 product would be developed internally as a concept beverage, and would not be sold or made available to the public until it is approved by Health Canada and relevant provincial regulatory bodies.

Under the agreement, Delta 9 will incur the costs and responsibility for marketing and distribution of the Phase 2 cannabis beer, which could not legally be sold in liquor stores.

"Since Delta 9 is one of the companies awarded a retail license from the Province of Manitoba, we are ideally placed for distribution and sale of this type of product," explained Delta 9 CEO John Arbuthnot.

"Legal lager is a hemp based beer, so it's something new we've created," said Fort Garry's head brewer Daniel Geddes. "It's quite unique in the industry and there's not a lot of hemp beers available. We wanted to add a little more complexity to this beer, as well as showcase the hemp itself.

"Frankly as it competes with alcohol or soda pop or other beverages, we've got something that's lighter on alcohol and doesn't give you a hangover; that's a pretty competitive value proposition," Arbuthnot said.

Coverage of the Legal Launch can be seen on CityTV News: https://winnipeg.citynews.ca/video/2018/06/08/hemp-infused-beer-coming-to-canada/

"We see this as a great partnership between two of Manitoba's best-known brands," Arbuthnot added. "Fort Garry Brewing is one of the best craft brewers in Canada and they make my favourite beer, while Delta 9 is truly Manitoba's Own Cannabis Producer.

"This is a Made-in-Manitoba product that's ready for people in our province to enjoy this summer."

About Delta 9 Cannabis Inc.
Delta 9's wholly-owned subsidiary, Delta 9 Bio-Tech Inc., is a licensed producer of medical marijuana pursuant to the ACMPR and operates an 80,000 square foot production facility in Winnipeg, Manitoba, Canada. Delta 9's shares trade on the TSX Venture Exchange under the symbol "NINE".

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Disclaimer for Forward-Looking Information

Certain statements in this release are forward-looking statements, which reflect the expectations of management regarding the Company's future business plans and other matters. Forward-looking statements consist of statements that are not purely historical, including any statements regarding beliefs, plans, expectations or intentions regarding the future. Forward looking statements in this news release include statements relating to: (i) Delta 9's expansion plans; (ii) Delta 9's production of cannabis; (iii) approvals for Delta 9's production facilities by Health Canada; (iv) demand for Delta 9's products; and (v) Delta 9's cost to produce its grow pods. Such statements are subject to risks and uncertainties that may cause actual results, performance or developments to differ materially from those contained in the statements, including that Delta 9's currently contemplated expansion and development plans may cease or otherwise change, Delta 9's production of cannabis may be lower than expected, Delta 9 may not obtain the required approvals from Health Canada, demand for Delta 9's products may be lower than anticipated, Delta 9's cost to produce its grow pods may be higher than expected and all other risk factors set forth in the filing statement of Delta 9 dated October 25, 2017 which has been filed on SEDAR. No assurance can be given that any of the events anticipated by the forward-looking statements will occur or, if they do occur, what benefits the Company will obtain from them. Readers are urged to consider these factors carefully in evaluating the forward-looking statements contained in this news release and are cautioned not to place undue reliance on such forward-looking statements, which are qualified in their entirety by these cautionary statements. These forward-looking statements are made as of the date hereof and the Company disclaims any intent or obligation to update publicly any forward-looking statements, whether as a result of new information, future events or results or otherwise, except as required by applicable securities laws.

- Patients living in Alberta, Saskatchewan, Manitoba, Ontario and Newfoundland and Labrador are hopeful Uptravi will soon be accessible all across Canada -

VANCOUVER and HAMILTON, ON, June 12, 2018 /CNW/ - The Pulmonary Hypertension Association of Canada (PHA Canada) and Scleroderma Canada join together in praising the Alberta, Saskatchewan, Manitoba, Ontario and Newfoundland and Labrador governments for following Quebec's lead by providing public funding for Uptravi (selexipag) for the treatment of pulmonary arterial hypertension (PAH). This action stems from the conclusion of pricing negotiations for Uptravi by the pan-Canadian Pharmaceutical Alliance (pCPA). The PAH and scleroderma communities are hopeful that the remaining provinces and territories across Canada will promptly follow suit to ensure that PAH specialists are able to provide optimal, individualized treatment to improve the outcomes for patients living with this potentially fatal disease.

"The voices of the PAH and scleroderma communities have been heard. We commend the provinces of Alberta, Saskatchewan, Manitoba, Ontario and Newfoundland and Labrador, for joining Quebec and making Uptravi accessible through public funding," says Dr. Sanjay Mehta, MD, FRCPC, FCCP, Director of the Southwest Ontario Pulmonary Hypertension Clinic at the London Health Sciences Center in London, Ontario, and Board Chair of PHA Canada. "While these provinces have recognized the highly complex and serious nature of PAH, our work will not be done until the balance of patients in Canada have timely and equitable access to optimal treatment options."

In January 2016, Uptravi became the third new treatment for PAH to be approved by Health Canada in recent years. Later that year, the Common Drug Review (CDR) also recommended Uptravi be publicly funded in Canada.

"We are so pleased to now be able to tell our patients that Alberta has joined the expanding list of provinces providing public funding for Uptravi," says Dr. Dale Lien MD, Professor of Medicine, Director Pulmonary Hypertension Program, University of Alberta. "The severe and progressive nature of pulmonary arterial hypertension means that patients must have timely access to all Health Canada-approved treatments for PAH, in order to receive the individualized care they require to improve and extend their lives."

PAH is a rare but very complex and serious lung disease. It is defined by high blood pressure in the lungs, which leads to enlargement and weakness of the right side of the heart – a type of heart failure. PAH is a common complication of systemic scleroderma (SSc), a chronic hardening and thickening of the skin and internal organs, and can be very severe in patients affected by this progressive connective tissue disease.

"My world was turned upside down following my diagnosis with pulmonary arterial hypertension. On any given day, even with the treatments I am on, the most I can do is take my young children to and from school – I'm lucky if I have the energy to do anything else. My disease not only affects me but my whole family, as I am more dependent on them now," says Ladho S. Panesar-Chugger, PAH patient in Markham, Ontario. "My life depends on adding a third medication to my treatment regime, and my specialist has been recommending Uptravi for many months. As an Ontarian who relies on public funding, I will now finally have access to it. That's my wish for all Canadians like me."

There is currently no cure for PAH and while the prognosis for patients has improved somewhat in recent years, it remains poor despite treatments available in Canada. The average survival in adults following a PAH diagnosis is estimated at only five to seven years, and only three years for those affected by scleroderma-associated PAH (SSc-PAH). This means that patients do not have the time to wait for necessary, potentially life-extending treatment options to be made accessible through public funding.

"Those living with PAH or SSc-PAH do not have time to wait for necessary treatment. Take my mother's experience, for example; she lost her battle with SSc-PAH in November 2017 while waiting for publicly funded access to treatment," says Stephanie Keyes, daughter and SSc-PAH caregiver from Gananoque, Ontario. "As a family, we consider her journey to be her legacy. Our hope is that sharing her story will benefit others who are also pleading for treatments not accessible to them through their provincial drug plans. For many suffering with this condition, these treatments are a matter of life or death."

Today, approximately 85 per cent of Canadians now have publicly funded access to Uptravi. The PAH and scleroderma communities are optimistic that all patients living in Canada who rely on provincial or territorial drug plans will soon have access to Uptravi.

Please visit TakeActionPAH.ca for more information.