Hey Guys! I recently was given a code from Lesley Logan of www.lesleyloganpilates.com to share with you for Pilates Anytime!
She wanted to offer a coupon code for me to share with you for a 30 day free trial of PilatesAnytime.com.
PilatesAnytime.com is an online Pilates studio, delivering world-class instruction anywhere, anytime, at an affordable price. Many people are unable to attend Pilates classes due to the lack of easy access to studios, schedule conflicts, and cost. PilatesAnytime was created as a result of the desire to offer the highest quality Pilates classes to everyone.
Lesley has one of her classes on their platform and wanted to extend the code to my readers.
"I hope your readers find value in this coupon code for their own personal practice."
Who is Lesley Logan:
PMA Certified Pilates Teacher. Completed multiple Pilates Masters programs. Voted 'Best Pilates in Los Angeles' by Los Angeles Magazine. Maintains dozens of private clients and leads Pilates retreats around the world.
OFFER:
Use coupon code
LLOGAN at
PilatesAnytime.com for 30 days free trial to their 2500 online Pilates classes.
LESLEY'S CLASSES ON PILATESANYTIME:
Not All Fish Oil Is Created Equal - Omax Ultra Pure - Product Review

As many of you know I take a lot of supplements being an athlete and competitive figure competitor. I was recently sent Omax Ultra Pure fish oils to try and review.
On the products website they state that: "Fish oil contains omega-3s, but how much you are getting in each supplement can vary dramatically. To determine the actual omega-3 content in your fish oil supplement, read the label and look for the total omega-3 content in each softgel. The top selling fish oil supplements contain only 30% of omega-3 content in each softgel.* Omax3 Ultra-Pure is exceptionally concentrated at 93.9%. That means you get therapeutic results that you can feel."

At first site the pills are pretty big. So if you aren't a fan of big pills be cautious. They are soft gels which do make them easier to swollow.
I have been taking them for a week and although I am not sure if they are better than my previous brand my training and cardio is going well. My joints feel great and overall I have no problem swelling the pills.
If you are interested you can find out more information about them here:
https://omaxhealth.com
Happy Training It Right!!!

NYC ENT Releases Infographic 5 Things You Need to Know About Your Sinuses

Celebrity Trainers Erin Oprea and Shawn Booth Bring Popular Workout Party to Canada along with Canadian Native Kaitlyn Bristowe

WHAT: Celebrity trainer Erin Oprea (personal trainer to Carrie Underwood, Kelsea Ballerini and Jana Kramer) and "The Bachelorette's" Shawn Booth and Kaitlyn Bristowe are bringing CitySTRONG across the border to Canada!
Bristowe from The Bachelorette, will DJ the event spinning some of the hottest tracks to get the crowd excited and ready to workout.
A portion of CitySTRONG’s proceeds benefits CreatiVets, an organization that provides disabled veterans with the opportunity to use art, music and creative writing to address service-related traumas. Erin Oprea is a Marine who served two tours in Iraq.
WHERE: Fort York Garrison Common I 100 Garrison Road
WHEN: August 26, 2017 at 11:00 AM
TICKETS: Register online at CITYSTRONG.com
General Admission - $51 (CAD)
VIP Tickets (Meet & Greet) - $97 (CAD)
Falling under the category of health education, jobs in the diet and wellness industry are expected to grow at a faster-than-average rate through 2024 according to the Bureau of Labor Statistics. Diet and wellness workers are employed in a broad range of settings, such as hospitals, nonprofit organizations, colleges and universities, doctors offices, private businesses, and more.
To give job seekers an idea of the types of companies that hire for diet and wellness jobs, FlexJobs has selected a sample of companies hiring right now for these types of positions, and featured currently available job with each company.
Here are 10 great companies in the diet and wellness industry currently hiring for flexible jobs:
- Sodexo
Dietician I: Candidate will be responsible for providing nutritional care and support to patients. Other duties include managing, promoting, and educating individuals on nutrition programs and ensuring compliance with government regulations. This is a part-time, flexible schedule job in Yakima, Washington, that requires a bachelor’s degree and Washington State licensure.
- Purdue University
Research Associate: A research associate is needed in Indianapolis, Indiana, to provide bio nutrition services, consult with faculty on diet related issues, and facilitate dietary services for human research. Successful candidates will be registered dietitians willing to work a part-time schedule with occasional travel.
- Hazelden Betty Ford Foundation
Wellness Technician: In this role, successful candidates will provide wellness programs for patients, members, and employees; maintain fitness equipment and departmental supplies; and oversee exercise facilities. A diploma and knowledge of exercise physiology are needed for this occasional job.
- Jenny Craig
Health and Wellness Consultant: Helping members achieve health and wellness goals are the primary duties of this consulting job in Hawaii. This is a part-time position that requires a high school diploma or equivalent, sales or retail experience, computer skills, and scheduling flexibility.
- Fitt
Writer, Health and Fitness: A writer in Nashville, Tennessee, with thorough knowledge of the local fitness scene is needed to generate new topics, craft headlines, and write, edit, and proofread articles. This is a freelance and remote position.
- Sanford Health
Profile Coach: A profile coach is needed in Evansville, Indiana, to coach individuals participating in a weight management program. This part-time job requires a bachelor’s degree. Ideal candidates will have at least six months’ relevant experience.
- Retrofit
Bilingual Wellness Expert: A bilingual registered dietician is needed for a part-time, virtual position in Chicago, Illinois. In this role, successful candidates with work with assigned clients to help them achieve weight loss and wellness goals. A master’s degree is required for this part-time, remote job.
- Johns Hopkins University
Intervention Assistant: An intervention assistant is needed for a part-time, Baltimore-based position. In this role, you would be helping support young people with emotional disturbances and their families. This job involves working with an interventionist on various tasks and promoting healthy weight and wellness.
- Humana
Specialist and Wellness Center Coordinator: Working under a manager’s supervision, the specialist and wellness center coordinator is responsible for overseeing the day-to-day operations of the Specialist and Wellness Center. In this role, successful candidates will help improve the health and well-being of the community. A high school diploma and at least two years’ relevant experience is needed for this part-time job in New Braunfels, Texas.
- Harlem Children’s Zone
Nutrition Educator: A nutrition educator is needed for a healthy living program in New York City. This is a part-time job that involves teaching cooking and nutrition classes, documenting activities, attending training, and helping with various projects. A bachelor’s degree in nutrition and experience is needed for this position.
Ontario gets its first Anatomage Table as CMCC enhances its anatomy program
Canadian Memorial Chiropractic College integrates 3-D virtual dissection into anatomy curriculum
TORONTO, Aug. 24, 2017 /CNW/ - The Canadian Memorial Chiropractic College (CMCC) is now the first health care education institution in Ontario to enhance its learning environment with the acquisition of the Anatomage Table, an advanced digital anatomy visualization system. The table, one of only four in Canada – is a life-sized virtual dissection table preloaded with male and female digital bodies in addition to 300 pathology cases built on animal and human models and will become an integral part CMCC's foundational anatomy program that includes cadaver work and a minimum of 329 hours of study within the 4,200-hour Doctor of Chiropractic program.
The Anatomage Table 5 will be integrated into the full curriculum beginning this fall. It includes three full body cadavers completely annotated and dissectible using special digital tools. It makes use of high quality graphics and flexibility of display, while touch screen manipulation of the models allows the user to remove select layers of tissue to highlight specific systems and allows for repeated dissection and rotation of the body. A pen tool allows an instructor to make further annotations and highlight areas, while the images can be projected onto a screen and saved onto a USB drive.
"It's a powerful clinical tool," says Dr. David Wickes, President of CMCC. "It doesn't diminish the importance of cadavers for understanding the nuances of the human body or the ability to view real tissues in 3D, but with its technical capabilities, serves to augment traditional dissection and is extremely versatile for our students and instructors, allowing integration with microanatomy, histology X-ray, CT and MRI images."
"From an educational perspective, this is an exciting technology in line with adult learning principles that will provide another viewpoint in the study of anatomy," says Dr. Scott Dunham, Director of Curriculum and Faculty Development," It has the potential for expansion into other areas of study, such as diagnostic imaging."
CMCC is one of 10 institutes of higher learning in Ontario with its own cadaver lab, which it has maintained since it opened in 1945. The anatomy program remains a vital part of the chiropractic program in ensuring a comprehensive understanding of the body and its intricate systems.
CMCC's body donation program is provincially controlled by the Chief Coroner's Office and regulated by the Anatomy Act of Ontario.
About CMCC
The Canadian Memorial Chiropractic College is recognized for creating leaders in spinal health. With graduates practicing in 37 countries and faculty who are leaders in their fields, CMCC delivers world class chiropractic education, research, and patient care. The campus features modern teaching and laboratory space, including new simulation and biomechanics laboratories, and is extended across Toronto through its network of community based interprofessional clinics. CMCC offers a four-year undergraduate program leading to a Doctor of Chiropractic Degree. For more information, visit www.cmcc.ca or follow us on Twitter and Facebook and Linkedin.
SOURCE Canadian Memorial Chiropractic College
Have a Bad Back? What It Takes to Manage Your Pain & Discomfort

Back aches and pains can negatively impact your life in many different ways. In addition to seeing your doctor, there are some extra steps that you can take to ease your pain and discomfort. Here are a few different methods that you can try to relieve bad back symptoms.
Perform Safe Exercises
Even though you may be inclined to sit a lot or climb into bed and rest to ease your aching back, exercising can actually be more beneficial. Staying active can relieve back pain more than just resting alone by keeping your tendons, ligaments and spinal discs flexible. Working out may also prevent your muscles from stiffening and weakening, which can lead to further back problems. Just be sure to do exercises that aren’t too strenuous and avoid things like lifting heavy weights or trying to do your own air conditioning repairs. Ideal exercises for relieving back pain include walking, swimming and stationary biking.
Adjust Your Chair
The way you sit might be contributing to your bad back without you even knowing it. You may have to adjust the height of your office chair so that you aren’t hunching or overreaching while working on your computer or performing other office tasks. Your office chair should support your natural spinal curvature. It is further important to make sure that your feet are touching the floor to reduce lower back strain. Adjusting your car seat so that you’re sitting closer to your steering wheel can also prevent back pain by keeping you from hunching, overreaching your arms or overstretching your legs.
Take the Right Supplements
Taking certain supplements can also help you manage your back pain and discomfort. Vitamin D helps with calcium absorption, and too little of this vitamin might make your back problems worse. Devils claw is great for reducing inflammation that contributes to low back pain. According to Everyday Health, turmeric is also known for its anti-inflammatory properties. Willow bark and magnesium are other useful supplements for relieving back aches.
Try Getting Acupuncture
This traditional Chinese form of medicine has the ability to provide fast relief for an aching back. A practitioner will lightly insert a series of small needles into different points on your back. This will allow energy to flow along meridians of your body. Your qi will be in better balance with acupuncture and provide further relief. Acupuncture can also stimulate the production of opioids in your body that act as natural pain killers.
You shouldn’t have to just live with a bad back. By getting the right medical care and making some simple changes to your life, you’ll have an easier time managing your back aches and pains. Of course, having a bad back can be tough. If you find that nothing that you’re doing is really working for you, consult the help of a professional and maybe even getting a surgery, like those done by the Surgery Center of Kenai.
Jazzercise Showcases Success of GirlForce Initiative that Offers Free Fitness to Young Women with an International Celebration on September 23
“Day of GirlForce” event celebrates global fitness company’s initiative to support teens and college-aged women to be active and confident by offering free fun workouts
(CARLSBAD, CA—AUGUST 23, 2017)—Leading global dance fitness company, Jazzercise, Inc. will celebrate the 2017 GirlForce initiative with a Day of GirlForce event on Saturday, September 23. Launched at the beginning of 2017, the GirlForceinitiative aims to empower teens and college-aged women by offering them a free place to get fit, learn healthy habits, and experience a positive sense of community through fun workout routines with like-minded women. The Global Dance Party Celebration will take place at participating Jazzercise facilities across the country and around the world and will be offered, like the rest of the initiative, at no charge.
The “Day of GirlForce” Celebration classes will consist of a special workout routine, with music and dance moves curated specifically for this class and youthful age group. The celebration playlist will feature hits from Lady Gaga, Ariana Grande, Shawn Mendes, Meghan Trainor, and Drake, among others, and studios will be lively decorated in gold, purple, and pink. Participants will also have the opportunity to use branded SnapChat filters and will be encourages to share the Day of GirlForce event via social media channels.
In business for almost 50 years, Jazzercise created the global GirlForce initiative to offer young women, ages 16-21, a safe place to workout, stay active and introduce them to a healthy and fun way to experience the endorphins of the workout “high.” The classes are being offered through the end of 2017 and are free of charge. Currently, approximately 2,000 monthly participants have taken advantage of the GirlForce program. Jazzercise classes integrate top-40 hit songs and the latest workout trends such as HIIT, also known as high intensity interval training, Pilates and cardio dance moves.
International participating Jazzercise locations will join the “Day of GirlForce” Celebration classes to inspire teens and college-aged women to be confident and to learn to dance their own path through fitness. “Our company culture has always been to give back, and this year our focus is on supporting young women in creating the healthy habits we’ve come to rely upon,” says CEO and Founder of Jazzercise, Inc., Judi Shepherd Missett.
While Jazzercise, Inc. and its franchisees have raised over $28MM for charities over their 48-year history, this the first time the company has developed a free corporate initiative. Young women who are interested in joining the GirlForce can find more information at jazzercise.com/GirlForce or follow the @jazzerciseinc Instagram page.
About Jazzercise
Jazzercise believes you can create a stronger, happier, healthier life through fitness. The company draws on the passion to motivate and inspire customers, instructors and employees to live healthier, fitter lives. Jazzercise develops fun and effective fitness routines and products that enhance the well-being of people of all ages. You can learn more about Jazzercise at www.jazzercise.com
How to Maximize Your Gains with Pre and Post Workout Nutrition
People who work out often face a dilemma in choosing what food to eat. Some opt to eat light snacks before working out and eat a heavy meal afterward. However, proper timing is as important as what food you eat. During workouts, the body needs fuel to function properly. The muscles also need to regenerate after a stressful activity to prevent weakness and injury.
Proper nutrition is crucial to prepare your body for a physical exercise. Your body also needs to recover after a physical training. What you eat and when to eat should be part of your fitness regimen so you can get the best workout gains.
Consuming a proper diet before and after a workout has a lot of benefits. First, you get to maximize your time in the gym because your body is fuelled properly. Second, your muscles recover faster and you won't feel fatigued or weak right after. Last, you are less prone to injuries because your muscles repair quickly.
Read on to learn some tips on how you can maximize your gains with proper pre- and post-workout nutrition:
- Nutrition Based on Type of Training
What is your usual training regimen? Different activities require different amounts of nutrition. This helps athletes and ordinary people fuel up before a workout and recover afterward.
Cardio training requires endurance. When you eat is a bigger factor than what you eat. It is best to consume a full meal at least 60 to 90 minutes before your workout. This allows the food to digest properly and give you enough energy without feeling sluggish. Eat a diet that is low in fat and sugar, moderate in protein, and high in complex carbohydrates.
Protein should be consumed within the 20-minute metabolic period. You should also consume electrolytes to rehydrate your body and replenish glycogen stores. Protein helps your muscles repair themselves after a strenuous activity. After an hour, consume a meal with small servings but prioritize simple carbs and proteins.
Strength training requires strength and endurance. Eating the proper food before a workout allows you to perform to the fullest.
1 to 2 hours before your session, eat a balanced meal of complex carbs and protein. Carbs help prevent your muscles from getting weak. Proteins help your muscles repair themselves. It would also be best to drink water or sports drinks every 20 minutes into your session. Water rehydrates your body and sports drinks contain carbs that boost your energy.
After your training session, consume a full meal that is high in proteins. The amino acids in proteins help repair worn-out muscles.
- Race and Marathon Training
If you are going to run the next day and need to prep, make sure that your body gets enough nutrition. Eating properly before your training helps you perform better.
The night before your training, consume a meal that is low in fiber and fat but high in carbs. In the morning, make sure your breakfast is high in carbs such as whole-grain cereals, whole wheat toast, and bananas.
During training, make sure you drink 3 to 6 ounces of fluid every 20 minutes into your session. Don't forget to weigh yourself before and after a workout. Why? After your exercise, you should replenish your fluid intake. You should drink 16 ounces of fluid for every pound of sweat that you lost. Consume 4 ounces of tart cherry juice after your workout. Cherry juice works best in muscle recovery and helps reduce muscle damage and inflammation so you don't get muscle cramps.
- What to Eat Before and After a Workout
What about for regular fitness buffs? What food can you eat before and after a physical exercise? Well, you also need to ensure that you get proper nutrition. Don't worry, you won't get fat. Make sure to follow these tips for a more effective workout gain.
Eat a full meal 1.5 to 2 hours before working out. This allows you to properly digest the food and still have enough energy. Consume a balanced meal of protein and complex carbs. Protein is great for muscle regeneration.
Complex carbs digest more slowly but without the sluggish feeling. Also, complex carbs help the muscles retain glycogen stores. When your body retains more glycogen, the more weights you can lift and the more energy you have.
It is also best to take supplements before your training session. B-vitamins provides more energy to fuel your workout. Ginko biloba and tyrosine motivates you to go through your sessions as they improve concentration and mental focus.
Some take creatine to quickly build muscle and increase water retention in the muscles. However, creatine can cause overexertion and damage the muscles. It would be best to find supplements without creatine and work on having proper nutrition.
Here's a list of foods that are recommended for a pre-workout meal:
- whole grain oats
- brown grains
- brown rice
- full-fat yogurt or Greek yogurt
- granola bars with nuts
- berries
- almond milk
- high-protein oatmeal
- bananas
- apples
- peanut butter
- hard-boiled egg
- avocados
- lean chicken
- sweet potatoes
- green beans
After working out, your body craves for carbs. You will also feel thirsty because of the water that you lost through sweating. Your muscles will also feel tired and aching. Proper nutrition after a strenuous activity helps you recover from these effects.
Consume proteins and electrolytes within the 20-minute metabolic period after a workout. At this time, your body absorbs more nutrients effectively. After an hour or two, eat a full meal composed of simple carbs and high-protein. Simple carbs help replenish the glycogen stores essential to muscle recovery.
Carbs also reintroduce glucose into your body. After a workout, your blood sugar drops because your muscles have already consumed the glycogen stores. This explains why you feel irritable and weak if you don't eat. Proteins help keep you full, restores the lost nutrients, and suppresses your appetite so your body doesn't crash.
What about for people who workout at night? Can you still consume a full meal before retiring to bed? You should. Your body still needs to recover and repair itself, so it needs proper nutrition. Otherwise, starving yourself leads to weakness, sleep problems, and you may be prone to injuries such as muscle cramps.
Here are some nutritious foods you can eat after a workout:
- hummus and pita bread
- tuna or salmon
- vegetables such as spinach, broccoli, butternut squash and carrots
- eggs
- nuts
- sweet potatoes
- fruits such as bananas, apples, bananas, berries, avocado
- lean chicken
- pasta
- olive oil
- white bread
- dark chocolate
Conclusion
Eating a proper diet is essential to healthy living. For people who are always on the go or have an active lifestyle, the more that you need to increase your intake of proteins and healthy carbs. People who are into sports, fitness training, strength training or aerobics should not rob themselves of food when they feel hungry. Proper nutrition and proper timing has more benefits and helps you achieve the maximum gains from your workout.
If you haven't started, why don't you go ahead and plan your meals for the week?
Author Bio
 |
Annie Jones is the person behind BoostBodyFit. She started off a bit on the chubby side but went through a transformation. She looks and feels great. Say Hi to Annie on Twitter, Facebook |
AbbVie's MAVIRET™ Approved by Health Canada for the Treatment of Chronic Hepatitis C in All Major Genotypes
- MAVIRET is the first and only 8-week, pan-genotypic treatment for hepatitis C patients without cirrhosis and who are new to treatment*1
- The approval is supported by a 97 percent (n=639/657) cure** rate across GT1-6 patients without cirrhosis and who are new to treatment2
- MAVIRET is the only pan-genotypic treatment approved for use in patients across all stages of chronic kidney disease
MONTREAL, Aug. 17, 2017 /CNW/ - AbbVie (NYSE: ABBV), a global biopharmaceutical company, today announced that Health Canada has granted approval for MAVIRET™ (glecaprevir/pibrentasvir tablets), a once-daily, ribavirin-free treatment for adults with chronic hepatitis C virus (HCV) infection across all major genotypes (GT1-6). MAVIRET is the only 8-week, pan-genotypic treatment for patients without cirrhosis and who are new to treatment,* who make up a large portion of HCV patients in Canada.

"Despite recent advances in HCV treatment, physicians still face challenges treating patients with less common genotypes and those with other complicating health conditions," said Dr. Morris Sherman, MD, FRCPC, Chairperson, Canadian Liver Foundation. "In order to eliminate hepatitis C in Canada, we need to identify all those living with the virus and have effective treatment options for everyone. This new therapy provides another tool for physicians to expand treatment to a greater number of patients while at the same time shortening the duration which may lead to cost savings for the health care system."
MAVIRET is also approved for use in patients with specific treatment challenges, including those with compensated cirrhosis across all major genotypes, and those who previously had limited treatment options, such as patients with severe chronic kidney disease (CKD), those GT1 patients not previously cured with certain direct-acting antiviral (DAA) treatment, and those with GT3 chronic HCV infection.2MAVIRET is the only pan-genotypic treatment approved for use in patients across all stages of CKD.2
"With the approval of MAVIRET, we are proud to bring the hope of a new cure to people living with hepatitis C in Canada, reflecting AbbVie's dedication to addressing critical unmet needs for patients," said Stéphane Lassignardie, General Manager, AbbVie Canada. "MAVIRET is designed to deliver a virologic cure for most HCV patients including those with specific treatment challenges. AbbVie will continue to work with local health authorities and stakeholders across Canada to get our treatment to as many patients as possible."
The efficacy and safety of MAVIRET was evaluated in nine Phase 2-3 clinical trials, in over 2,300 patients with genotype 1, 2, 3, 4, 5 or 6 HCV infection and with compensated liver disease (with or without cirrhosis).
Approximately 300,000 Canadians are infected with hepatitis C.3 In 2012 alone, more than 10,000 new cases of hepatitis C were reported, but 40 percent of patients are estimated to be living unaware of their disease.4 GT1 is the most common genotype in Canada and GT3 is the most difficult to treat.3,5 Over time chronic hepatitis C can lead to chronic liver diseases, with a risk of developing cirrhosis of up to 30 percent within 20 years6 of infection. Additionally, HCV is common among people with severe CKD, and some of these patients previously did not have a DAA-based treatment option.7
With 8 weeks of treatment, 97 percent (n= 639/657) of GT1-6 patients without cirrhosis and who were new to treatment achieved a virologic cure.1 These high cure rates were achieved in patients with varied patient and viral characteristics and including those with CKD.2 Additionally, 97.5 percent (n=274/281) of patients with compensated cirrhosis achieved a virologic cure with the recommended duration of treatment, including patients with CKD.2 In registrational studies for MAVIRET, less than 0.1 percent of patients permanently discontinued treatment due to adverse reactions.2 The most commonly reported adverse reactions (incidence greater than or equal to 10 percent) were headache and fatigue.2
"In an extensive clinical trial program, patients achieved high cure rates with MAVIRET regardless of genotype, fibrosis score, viral load, and even in patients with resistant virus strains and those with chronic kidney disease," said Dr. Magdy Elkhashab, Gastroenterologist/Hepatologist, Director of the Toronto Liver Centre. "In clinical practice, MAVIRET has the potential to simplify treatment decisions for physicians, offering, in one therapy, a cure for the majority of HCV patients and cutting out pre-testing before treatment initiation."
MAVIRET combines two new, potent direct-acting antivirals that target and inhibit proteins essential for the replication of the hepatitis C virus.2 The presence of most genotypes or baseline mutations that are commonly associated with resistance have been shown to have no relevant impact on efficacy.2
Canadians prescribed MAVIRET will have the opportunity to be enrolled in AbbVie Care, AbbVie's signature patient support program designed to provide a wide range of services including reimbursement assistance, education and ongoing disease management support. AbbVie Care will support people living with HCV throughout their treatment journey to achieve high cure rates in the real world.
Approval of MAVIRET followed Health Canada's Priority Review process, which is granted to new medicines intended for patients with a life-threatening disease where there is no existing treatment with the same profile or where the new product represents a significant improvement in the benefit/risk profile over existing products.8 AbbVie's investigational, pan-genotypic regimen was also recently approved by the European Commission and the U.S. Food and Drug Administration.
About MAVIRET™
MAVIRET™ is approved in Canada for the treatment of chronic hepatitis C virus (HCV) infection in adults across all major genotypes (GT1-6).2 MAVIRET is a new, pan-genotypic, once-daily, ribavirin-free treatment that combines glecaprevir (100 mg), an NS3/4A protease inhibitor, and pibrentasvir (40 mg), an NS5A inhibitor, dosed once-daily as three oral tablets.2
MAVIRET is an 8-week, pan-genotypic virologic cure** for use in patients without cirrhosis and who are new to treatment,* such patients comprising the majority of people living with HCV.1 MAVIRET is also approved as a treatment for patients with specific treatment challenges, including those with compensated cirrhosis across all major genotypes, and those who previously had limited treatment options, such as patients with severe chronic kidney disease (CKD) and those with genotype 3 infection.2 It is the only pan-genotypic treatment approved for use in patients across all stages of CKD.2
Glecaprevir (GLE) was discovered during the ongoing collaboration between AbbVie and Enanta Pharmaceuticals (NASDAQ: ENTA) for HCV protease inhibitors and regimens that include protease inhibitors.
*Patients without cirrhosis and new to treatment with DAAs [either treatment-naive or not cured with previous IFN-based treatments ([peg]IFN +/- RBV or SOF/RBV +/- pegIFN)].
**Patients who achieve a sustained virologic response at 12 weeks post treatment (SVR12) are considered cured of hepatitis C.
About AbbVie
AbbVie is a global, research-driven biopharmaceutical company committed to developing innovative advanced therapies for some of the world's most complex and critical conditions. The company's mission is to use its expertise, dedicated people and unique approach to innovation to markedly improve treatments across four primary therapeutic areas: immunology, oncology, virology and neuroscience. In more than 75 countries, AbbVie employees are working every day to advance health solutions for people around the world. For more information about AbbVie, please visit us at www.abbvie.ca and www.abbvie.com. Follow @abbvieCanada and @abbvie on Twitter or view careers on our Facebook or LinkedIn page.
1 Decisions Resources Group. Hepatitis C virus: disease landscape & forecast 2016. January 2017.
2 MAVIRET (glecaprevir/pibrentasvir tablets) Product Monograph. Date of Preparation: August 16, 2017.
3 Messina, JP et al. "The global distribution of HCV genotypes." Hepatology, 2015; 61: 77–87. Supporting information hep27259-sup-0001-suppinfo.pdf. Accessed August, 2017.
4 Hepatitis C: Get the Facts. Government of Canada. https://www.canada.ca/en/public-health/services/publications/diseases-conditions/poster-hepatitis-c-get-facts.html. Accessed August, 2017.
5 Wyles, D et al. SURVEYOR-II, Part 3: Efficacy and Safety of ABT-493/ABT-530 in Patients with Hepatitis C Virus Genotype 3 Infection with Prior Treatment Experience and/or Cirrhosis. Presented at the Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) in Boston, US on November 11-15, 2016.
6 Hepatitis C Fact Sheet. World Health Organization. World Health Organization, July 2017. Web. http://www.who.int/mediacentre/factsheets/fs164/en/. Accessed August, 2017.
7 Fabrizi F, Poordad FF, Martin P. Hepatitis C infection in the patient with end stage renal disease. Hepatology. 2002;36(1):3-10.
8 Priority Review of Drug Submissions. Government of Canada. https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/fact-sheets/priority-review-drug-submissions-therapeutic-products.html. Accessed August, 2017.
SOURCE AbbVie Canada